Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130779 - 130779
Published: Feb. 1, 2025
Language: Английский
Science Advances, Journal Year: 2024, Volume and Issue: 10(14)
Published: April 5, 2024
Trained immunity is one of the mechanisms by which BCG vaccination confers persistent nonspecific protection against diverse diseases. Genomic differences between different vaccine strains that are in global use could result variable tuberculosis and therapeutic effects on bladder cancer. In this study, we found four representative (BCG-Russia, BCG-Sweden, BCG-China, BCG-Pasteur) covering all genetic clusters differed their ability to induce trained protection. The induced was associated with Akt-mTOR-HIF1α axis, glycolysis, NOD-like receptor signaling pathway. Multi-omics analysis (epigenomics, transcriptomics, metabolomics) showed linoleic acid metabolism correlated immunity–inducing capacity strains. Linoleic participated induction act as adjuvants enhance BCG-induced immunity, revealing a pathway be used adjuvant development.
Language: Английский
Citations
16
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(19)
Published: Feb. 8, 2024
Intravesical Bacillus Calmette-Guérin (BCG) is a well-established strategy for managing high-risk nonmuscle-invasive bladder cancer (NMIBC); however, over half of patients still experience disease recurrence or progression. Although the combined intravesical instillation various chemotherapeutic drugs implemented in clinical trials to enhance BCG therapy, outcome far from satisfying due severe irritative effects and treatment intolerance at high doses. Therefore, it adopted "biotin-streptavidin strategy" doxorubicin (DOX)-encapsulated nanoparticles within live bacteria (DOX@BCG) improve outcomes. Adherence epithelium helps precisely target DOX@BCG local tumor cells simultaneously increases intratumoral transport therapeutic drugs. effectively inhibits progression prolongs survival rats/mice with orthotopic owing synergism between BCG-immunotherapy, DOX-chemotherapy, DOX-induced immunogenic cell death; furthermore, exhibits improved tolerance biosafety, establishes antitumor immunity microenvironment. drug-loaded bacterial delivery system holds considerable potential translation cancer.
Language: Английский
Citations
11
Phytomedicine, Journal Year: 2024, Volume and Issue: 127, P. 155503 - 155503
Published: Feb. 28, 2024
Language: Английский
Citations
11
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 16, 2024
While most of the cancer immunotherapy strategies engage adaptive immunity, especially tumor-associated T cells, small fraction responding patients and types cancers amenable, possibility severe adverse effects limit its usage. More effective general interventions are urgently needed. Recently, a de facto innate immune memory, termed ‘trained immunity’, has become new research focal point, promises to be powerful tool for achieving long-term therapeutic benefits against cancers. Trained immunity-inducing agents such as BCG fungal glucan have been shown able avert suppressive tumor microenvironment (TME), enhance cell responses, eventually lead regression. Here, we review current understating trained immunity induction highlight critical roles emergency granulopoiesis, interferon γ tissue-specific induction. Preclinical clinical studies that exploited inducers summarized, repurposed from other fields proposed. We also outline challenges opportunities in future immunotherapies. envisage more vaccines will combine with therapies.
Language: Английский
Citations
10
Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130779 - 130779
Published: Feb. 1, 2025
Language: Английский
Citations
1