Molecular topography of an entire nervous system

Cell, Journal Year: 2021, Volume and Issue: 184(16), P. 4329 - 4347.e23

Published: July 7, 2021

Language: Английский

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Connectomes across development reveal principles of brain maturation

Nature, Journal Year: 2021, Volume and Issue: 596(7871), P. 257 - 261

Published: Aug. 4, 2021

Language: Английский

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Fluid transport in the brain

Physiological Reviews, Journal Year: 2021, Volume and Issue: 102(2), P. 1025 - 1151

Published: May 5, 2021

The brain harbors a unique ability to, figuratively speaking, shift its gears. During wakefulness, the is geared fully toward processing information and behaving, while homeostatic functions predominate during sleep. blood-brain barrier establishes stable environment that optimal for neuronal function, yet imposes physiological problem; transcapillary filtration forms extracellular fluid in other organs reduced to minimum brain. Consequently, depends on special [the cerebrospinal (CSF)] flushed into along perivascular spaces created by astrocytic vascular endfeet. We describe this pathway, coined term glymphatic system, based dependency endfeet their adluminal expression of aquaporin-4 water channels facing CSF-filled spaces. Glymphatic clearance potentially harmful metabolic or protein waste products, such as amyloid-β, primarily active sleep, when drivers, cardiac cycle, respiration, slow vasomotion, together efficiently propel CSF inflow periarterial brain's space contains an abundance proteoglycans hyaluronan, which provide low-resistance hydraulic conduit rapidly can expand shrink sleep-wake cycle. system brain, meets requisites maintain homeostasis similar peripheral organs, considering blood-brain-barrier paths formation egress CSF.

Language: Английский

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FlyWire: online community for whole-brain connectomics

Nature Methods, Journal Year: 2021, Volume and Issue: 19(1), P. 119 - 128

Published: Dec. 23, 2021

Language: Английский

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NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans

Cell, Journal Year: 2020, Volume and Issue: 184(1), P. 272 - 288.e11

Published: Dec. 29, 2020

Language: Английский

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Neural circuit policies enabling auditable autonomy

Nature Machine Intelligence, Journal Year: 2020, Volume and Issue: 2(10), P. 642 - 652

Published: Oct. 13, 2020

Language: Английский

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The natverse, a versatile toolbox for combining and analysing neuroanatomical data

eLife, Journal Year: 2020, Volume and Issue: 9

Published: April 14, 2020

To analyse neuron data at scale, neuroscientists expend substantial effort reading documentation, installing dependencies and moving between analysis visualisation environments. facilitate this, we have developed a suite of interoperable open-source R packages called the natverse. The natverse allows users to read local remote data, perform popular analyses including clustering graph-theoretic neuronal branching. Unlike most tools, enables comparison across many neurons morphology connectivity after imaging or co-registration within common template space. also transformations different spaces modalities. We demonstrate tools that integrate vast majority

Language: Английский

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The Human Connectome Project: A retrospective

NeuroImage, Journal Year: 2021, Volume and Issue: 244, P. 118543 - 118543

Published: Sept. 8, 2021

The Human Connectome Project (HCP) was launched in 2010 as an ambitious effort to accelerate advances human neuroimaging, particularly for measures of brain connectivity; apply these study a large number healthy young adults; and freely share the data tools with scientific community. NIH awarded grants two consortia; this retrospective focuses on "WU-Minn-Ox" HCP consortium centered at Washington University, University Minnesota, Oxford. In just over 6 years, WU-Minn-Ox succeeded its core objectives by: 1) improving MR scanner hardware, pulse sequence design, image reconstruction methods, 2) acquiring analyzing multimodal MRI MEG unprecedented quality together behavioral from more than 1100 participants, 3) sharing (via ConnectomeDB database) associated analysis visualization tools. To date, 27 Petabytes have been shared, 1538 papers acknowledging use published. "HCP-style" neuroimaging paradigm has emerged set best-practice strategies optimizing acquisition analysis. This article reviews history HCP, including comments key events decisions major project components. We discuss several using data, improved cortical parcellations, analyses connectivity based functional diffusion MRI, brain-behavior relationships. also touch upon our efforts develop variety processing along detailed documentation, tutorials, educational course train next generation neuroimagers. conclude look forward opportunities challenges facing field perspective consortium.

Language: Английский

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Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity

Cell, Journal Year: 2022, Volume and Issue: 185(6), P. 1082 - 1100.e24

Published: Feb. 24, 2022

Language: Английский

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Neuronal wiring diagram of an adult brain

Nature, Journal Year: 2024, Volume and Issue: 634(8032), P. 124 - 138

Published: Oct. 2, 2024

Language: Английский

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