Skin-Interfaced Wearable Sweat Sensors for Precision Medicine

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(8), P. 5049 - 5138

Published: March 27, 2023

Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward healthcare. Advances flexible electronics, materials science, electrochemistry have spurred the development of wearable sweat that enable continuous noninvasive screening analytes indicative status. Existing major challenges include: improving extraction sensing capabilities, form factor device for minimal discomfort reliable measurements when worn, understanding clinical value biomarker discovery. This review provides a comprehensive outlines state-of-the-art technologies research strive to bridge these gaps. The physiology sweat, materials, biosensing mechanisms advances, approaches induction sampling are introduced. Additionally, design considerations system-level devices, spanning from strategies prolonged efficient powering wearables, discussed. Furthermore, applications, data commercialization efforts, challenges, prospects precision medicine

Language: Английский

---

3D printable high-performance conducting polymer hydrogel for all-hydrogel bioelectronic interfaces

Nature Materials, Journal Year: 2023, Volume and Issue: 22(7), P. 895 - 902

Published: June 15, 2023

Language: Английский

---

Highly Conducting and Stretchable Double‐Network Hydrogel for Soft Bioelectronics

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(15)

Published: Feb. 16, 2022

Conducting polymer hydrogels are promising materials in soft bioelectronics because of their tissue-like mechanical properties and the capability electrical interaction with tissues. However, it is challenging to balance conductivity stretchability: pure conducting highly conductive, but they brittle; while incorporating network a form double can improve stretchability, its significantly decreases. Here, problem addressed by concentrating poorly crosslinked precursor hydrogel high content ratio achieve densified double-network (5.5 wt% polymer), exhibiting both (≈10 S cm-1 ) large fracture strain (≈150%), addition biocompatibility, softness, low swelling ratio, desired electrochemical for bioelectronics. A surface grafting method further used an adhesive layer on hydrogel, enabling robust rapid bonding Furthermore, proposed applied show high-quality physiological signal recording reliable, low-voltage stimulation based vivo rat model. This provides ideal strategy reliable tissue-device integration communications.

Language: Английский

---

Bioinspired Self‐Healing Human–Machine Interactive Touch Pad with Pressure‐Sensitive Adhesiveness on Targeted Substrates

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(50)

Published: Nov. 10, 2020

Abstract There is an increasing interest to develop a next generation of touch pads that require stretchability and biocompatibility allow their integration with human body, even mimic the self‐healing behavior fast functionality recovery upon damage. However, most are developed based on stiff brittle electrodes lack important nature self‐healing. Polyzwitterion–clay nanocomposite hydrogels as soft, stretchable, transparent ionic conductor transmittance 98.8% fracture strain beyond 1500% developed, which can be used human–machine interactive pad pressure‐sensitive adhesiveness target substrates. A surface‐capacitive system adopted sense touched position. Finger positions perceived during both point‐by‐point continuous moving. Hydrogel adhered curved or flat insulators, high‐resolution self‐healable input functions demonstrated by drawing, writing, playing electronic games.

Language: Английский

---

Instant tough bioadhesive with triggerable benign detachment

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(27), P. 15497 - 15503

Published: June 23, 2020

Significance Owing to potential advantages including ease of use, airtight or watertight sealing, and minimal tissue damage, bioadhesives have been intensively studied developed as an alternative sutures staples close wounds, achieve hemostasis, attach immobilize implantable devices. However, existing limitations slow adhesion formation, weak bonding, low biocompatibility, poor mechanical match with tissues, and/or lack triggerable benign detachment. In this work, we report a bioadhesive capable instant tough detachment that can potentially address all the above-mentioned limitations. The current work not only develops superior performances but also advances understanding wet adhesion.

Language: Английский

---

Bioinspired Underwater Adhesives

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(44)

Published: Sept. 17, 2021

Abstract Underwater adhesives are in high demand both commercial and industrial sectors. Compared with used dry (air) environments, for wet or submerged surfaces aqueous environments have specific challenges development performance. In this review, focus is on demonstrating macroscopic adhesion to wet/underwater substrates. The current strategies first introduced different types of underwater adhesives, then an overview provided the performance based mechanisms strategies. Finally, possible research directions prospects discussed.

Language: Английский

---

Emerging Implantable Energy Harvesters and Self-Powered Implantable Medical Electronics

ACS Nano, Journal Year: 2020, Volume and Issue: 14(6), P. 6436 - 6448

Published: May 27, 2020

Implantable energy harvesters (IEHs) are the crucial component for self-powered devices. By harvesting from organisms such as heartbeat, respiration, and chemical redox reaction of glucose, IEHs utilized power source implantable medical electronics. In this review, we summarize electronics (SIMEs). The typical nanogenerators, biofuel cells, electromagnetic generators, transcutaneous devices that based on ultrasonic or optical energy. A benefit these technologies in vivo, SIMEs emerged, including cardiac pacemakers, nerve/muscle stimulators, physiological sensors. We provide perspectives challenges potential solutions associated with SIMEs. Beyond issue, highlight implanted show therapeutic function vivo.

Language: Английский

---

Functional Conductive Hydrogels for Bioelectronics

ACS Materials Letters, Journal Year: 2020, Volume and Issue: 2(10), P. 1287 - 1301

Published: Aug. 25, 2020

Conductive hydrogels are widely used in various applications, such as artificial skin, flexible and implantable bioelectronics, tissue engineering. However, it is still a challenge to formulate with high electrical conductivity without compromising their physicochemical properties (e.g., toughness, stretchability, biocompatibility). Additionally, incorporating other functions, self-healing, shape memory, wet adhesion, into conductive critical many practical applications of hydrogel bioelectronics. In this Review, we highlight recent progress the development functional hydrogels. We, then, discuss potential challenges faced by areas wearable/implantable electronics cell/tissue can serve an important building block for bioelectronic devices personalized healthcare bioengineering areas.

Language: Английский

---

From Diagnosis to Treatment: Recent Advances in Patient-Friendly Biosensors and Implantable Devices

ACS Nano, Journal Year: 2021, Volume and Issue: 15(2), P. 1960 - 2004

Published: Feb. 3, 2021

Patient-friendly medical diagnostics and treatments have been receiving a great deal of interest due to their rapid cost-effective health care applications with minimized risk infection, which has the potential replace conventional hospital-based procedures. In particular, integration recently developed materials into devices allows development point-of-care (POC) sensing platforms implantable special functionalities. this review, recent advances in biosensors for patient-friendly diagnosis treatment are discussed. Comprehensive analysis portable wearable biosensing monitoring disease is provided, including topics such as selection, device structure integration, biomarker detection strategies. Moreover, specific challenges related each biological fluid biosensor-based POC presented. Also, devices, wireless communication strategies, Furthermore, various surgical approaches reviewed, minimally invasive insertion mounting, vivo electrical optical modulations, post-operation monitoring. Finally, future perspectives toward provided.

Language: Английский

---

An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats

Science Translational Medicine, Journal Year: 2020, Volume and Issue: 12(534)

Published: March 11, 2020

Cell-laden hydrogels are widely used in tissue engineering and regenerative medicine. However, many of these not optimized for use the oral environment, where they exposed to blood saliva. To address challenges, we engineered an alginate-based adhesive, photocrosslinkable, osteoconductive hydrogel biomaterial (AdhHG) with tunable mechanical properties. The was as injectable mesenchymal stem cell (MSC) delivery vehicle craniofacial bone applications. Subcutaneous implantation mice confirmed biodegradability, biocompatibility, osteoconductivity hydrogel. In a well-established rat peri-implantitis model, application adhesive encapsulating gingival cells (GMSCs) resulted complete regeneration around ailing dental implants peri-implant loss. Together, have developed distinct bioinspired properties biodegradability that effectively delivers patient-derived dental-derived MSCs. is photocrosslinkable and, due presence MSC aggregates hydroxyapatite microparticles, promotes

Language: Английский

---