Small,
Journal Year:
2023,
Volume and Issue:
19(27)
Published: March 28, 2023
Abstract
Currently
used
wound
dressings
are
ineffective.
Hence,
there
is
a
need
to
develop
introduce
high‐performance
medicament
with
multiple
functions
including
rapid
hemostasis
and
excellent
antibacterial
activity
meet
the
growing
worldwide
demand
for
healing
products.
Here,
inspired
by
strong
adhesion
of
mussels
enzyme‐mimicking
nanometallic
biomaterials,
authors
developed
an
injectable
hydrogel
overcome
limitations
current
dressings.
The
synthesized
via
esterification
reaction
between
poly(vinyl
alcohol)
(PVA)
3,4‐dihydroxyphenylalanine
(DOPA),
followed
catechol‐metal
coordination
Cu
2+
catechol
groups
DOPA
form
PVA‐DOPA‐Cu
(PDPC)
hydrogel.
PDPC
possesses
tissue
adhesive,
antioxidative,
photothermal,
antibacterial,
hemostatic
properties.
rapidly
efficiently
stopped
bleeding
under
different
traumatic
conditions,
otherwise‐lethal
liver
injury,
high‐pressure
carotid
artery
rupture,
even
fatal
cardiac
penetration
injuries
in
animal
models.
Furthermore,
it
demonstrated
that
affected
repair
regeneration
accelerating
re‐epithelialization,
promoting
collagen
deposition,
regulating
inflammation,
contributing
vascularization.
results
show
promising
candidate
hemorrhage
control
efficient
clinical
applications.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(4), P. 7078 - 7093
Published: March 25, 2021
The
design
and
development
of
a
smart
bioadhesive
hydrogel
sealant
with
self-healing
excellent
antibacterial
activity
to
achieve
high
wound
closure
effectiveness
post-wound-closure
care
is
highly
desirable
in
clinical
applications.
In
this
work,
series
adhesive
antioxidant
hydrogels
promising
traits
were
designed
through
dual-dynamic-bond
cross-linking
among
ferric
iron
(Fe),
protocatechualdehyde
(PA)
containing
catechol
aldehyde
groups
quaternized
chitosan
(QCS)
enable
the
skin
incisions
promotion
methicillin-resistant
Staphylococcus
aureus
(MRSA)-infected
healing.
pH-sensitive
coordinate
bond
(catechol–Fe)
dynamic
Schiff
base
bonds
reversible
breakage
re-formation
equips
autonomous
healing
on-demand
dissolution
or
removal
properties.
Additionally,
presents
injectability,
good
biocompatibility
activity,
multifunctional
adhesiveness,
hemostasis
as
well
NIR
responsiveness.
vivo
evaluation
rat
incision
model
infected
full-thickness
revealed
hydrogels,
demonstrating
its
great
potential
dealing
wounds.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(18), P. 11336 - 11384
Published: Jan. 28, 2021
Polymeric
tissue
adhesives
provide
versatile
materials
for
wound
management
and
are
widely
used
in
a
variety
of
medical
settings
ranging
from
minor
to
life-threatening
injuries.
Compared
the
traditional
methods
closure
(i.e.,
suturing
stapling),
they
relatively
easy
use,
enable
rapid
application,
introduce
minimal
damage.
Furthermore,
can
act
as
hemostats
control
bleeding
tissue-healing
environment
at
site.
Despite
their
numerous
current
applications,
still
face
several
limitations
unresolved
challenges
(e.g.,
weak
adhesion
strength
poor
mechanical
properties)
that
limit
leaving
ample
room
future
improvements.
Successful
development
next-generation
will
likely
require
holistic
understanding
chemical
physical
properties
tissue-adhesive
interface,
fundamental
mechanisms
adhesion,
requirements
specific
clinical
applications.
In
this
review,
we
discuss
set
rational
guidelines
design
adhesives,
recent
progress
field
along
with
examples
commercially
available
those
under
development,
tissue-specific
considerations,
finally
potential
functions
adhesives.
Advances
open
new
avenues
care
potentially
potent
therapeutics
various
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 5604 - 5640
Published: Jan. 13, 2022
Tissue
engineering
is
a
promising
and
revolutionary
strategy
to
treat
patients
who
suffer
the
loss
or
failure
of
an
organ
tissue,
with
aim
restore
dysfunctional
tissues
enhance
life
expectancy.
Supramolecular
adhesive
hydrogels
are
emerging
as
appealing
materials
for
tissue
applications
owing
their
favorable
attributes
such
tailorable
structure,
inherent
flexibility,
excellent
biocompatibility,
near-physiological
environment,
dynamic
mechanical
strength,
particularly
attractive
self-adhesiveness.
In
this
review,
key
design
principles
various
supramolecular
strategies
construct
comprehensively
summarized.
Thereafter,
recent
research
progress
regarding
applications,
including
primarily
dermal
repair,
muscle
bone
neural
vascular
oral
corneal
cardiac
fetal
membrane
hepatic
gastric
systematically
highlighted.
Finally,
scientific
challenges
remaining
opportunities
underlined
show
full
picture
hydrogels.
This
review
expected
offer
comparative
views
critical
insights
inspire
more
advanced
studies
on
pave
way
different
fields
even
beyond
applications.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(22)
Published: Feb. 28, 2021
Bone
bleeding
and
bone
defects
arising
from
trauma
or
tumor
resection
pose
a
great
threat
to
patients
they
are
challenging
problems
orthopedic
surgeons.
Traditional
hemostatic
materials
not
suitable
for
fractures
where
compression
cannot
be
applied,
neither
effective
during
surgeries
large
amounts
of
body
fluids
prevent
them
adhering
the
irregular
wound
sites.
This
research
introduces
catechol-conjugated
chitosan
(CHI-C)
multi-functional
hydrogel
with
adhesion,
self-healing,
cytocompatibility,
hemocompatibility,
blood
cell
coagulation
capacity.
The
can
injected
into
internal
sites
defective
areas,
then
rapidly
self-heals
(within
2
min)
an
integrated
that
fully
fills
strongly
sticks
areas
in
presence
surgery.
In
vivo
experiments
using
rabbit
ilium
defect
model
demonstrate
quick
hemostasis
after
is
applied
loss
only
¼
compared
untreated
injuries.
addition,
regeneration
interfered
by
no
longer
visible
disappearance
4
weeks.
potentially
valuable
clinical
applications
towards
tissue
hemostasis,
regeneration.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(38)
Published: Aug. 4, 2021
Abstract
Bacteria
are
one
of
the
main
groups
organisms,
which
dynamically
and
closely
participate
in
human
health
disease
development.
With
integration
chemical
biotechnology,
bacteria
have
been
utilized
as
an
emerging
delivery
system
for
various
biomedical
applications.
Given
unique
features
such
their
intrinsic
biocompatibility
motility,
bacteria‐based
systems
drawn
wide
interest
diagnosis
treatment
diseases,
including
cancer,
infectious
kidney
failure,
hyperammonemia.
Notably,
at
interface
biotechnology
bacteria,
many
research
opportunities
initiated,
opening
a
promising
frontier
application.
Herein,
current
synergy
design
principles
systems,
microbial
modulation,
clinical
translation
reviewed,
with
special
focus
on
advances
therapy.
Regenerative Biomaterials,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 1, 2022
Nowadays,
biomaterials
have
evolved
from
the
inert
supports
or
functional
substitutes
to
bioactive
materials
able
trigger
promote
regenerative
potential
of
tissues.
The
interdisciplinary
progress
has
broadened
definition
'biomaterials',
and
a
typical
new
insight
is
concept
tissue
induction
biomaterials.
term
'regenerative
biomaterials'
thus
contents
this
article
are
relevant
yet
beyond
This
review
summarizes
recent
medical
including
metals,
ceramics,
hydrogels,
other
polymers
bio-derived
materials.
As
application
aspects
concerned,
introduces
for
bone
cartilage
regeneration,
cardiovascular
repair,
3D
bioprinting,
wound
healing
cosmetology.
Cell-biomaterial
interactions
highlighted.
Since
global
pandemic
coronavirus
disease
2019,
particularly
mentions
public
health
emergency.
In
last
section,
perspectives
suggested:
(i)
creation
source
innovation;
(ii)
modification
existing
an
effective
strategy
performance
improvement;
(iii)
biomaterial
degradation
regeneration
required
be
harmonious
with
each
other;
(iv)
host
responses
can
significantly
influence
clinical
outcomes;
(v)
long-term
outcomes
should
paid
more
attention
to;
(vi)
noninvasive
approaches
monitoring
