The inflammatory speech of fibroblasts

Immunological Reviews, Journal Year: 2021, Volume and Issue: 302(1), P. 126 - 146

Published: May 13, 2021

Activation of fibroblasts is a key event during normal tissue repair after injury and the dysregulated processes that result in organ fibrosis. To most researchers, are rather unremarkable spindle-shaped cells embedded fibrous collagen matrix connective tissues and/or deemed useful to perform mechanistic studies with adherent culture. For more than century, escaped thorough classification due lack specific markers were treated as leftovers all other have been identified from sample. With novel cell lineage tracing single transcriptomics tools, bona fide emerge only one heterogeneous sub-population much larger group partly overlapping types, including mesenchymal stromal cells, fibro-adipogenic progenitor pericytes, perivascular cells. All these activated contribute chronic inflammation. "Activation" can entail various functions, such enhanced proliferation, migration, instruction inflammatory secretion extracellular proteins organizing enzymes, acquisition contractile myofibroblast phenotype. We provide our view on fibroblastic types activation states playing role physiological pathological their crosstalk macrophages. Inflammation fibrosis articular synovium rheumatoid arthritis osteoarthritis used examples discuss fibroblast phenotypes. Ultimately, delineating precursors functional roles will better intervention strategies treat fibroproliferative fibrocontractive disorders.

Language: Английский

---

Mechanical communication in fibrosis progression

Trends in Cell Biology, Journal Year: 2021, Volume and Issue: 32(1), P. 70 - 90

Published: Nov. 19, 2021

Language: Английский

---

Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary

Science Advances, Journal Year: 2022, Volume and Issue: 8(24)

Published: June 17, 2022

The female ovary contains a finite number of oocytes, and their release at ovulation becomes sporadic disordered with aging obesity, leading to loss fertility. Understanding the molecular defects underpinning this pathology is essential as age childbearing obesity rates increase globally. We identify that fibrosis within ovarian stromal compartment an underlying mechanism responsible for impaired oocyte release, which initiated by mitochondrial dysfunction diminished bioenergetics, oxidative damage, inflammation, collagen deposition. Furthermore, antifibrosis drugs (pirfenidone BGP-15) eliminate fibrotic restore in reproductively old obese mice, association dampened M2 macrophage polarization up-regulated MMP13 protease. This first evidence reversible indicates targeting metabolism may be viable therapeutic strategy women metabolic disorders or advancing maintain function extend

Language: Английский

---

The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon

Immunity, Journal Year: 2023, Volume and Issue: 56(2), P. 444 - 458.e5

Published: Jan. 30, 2023

Language: Английский

---

Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction

Cells, Journal Year: 2021, Volume and Issue: 10(7), P. 1794 - 1794

Published: July 15, 2021

Body implants and implantable medical devices have dramatically improved prolonged the life of countless patients. However, our body repair mechanisms evolved to isolate, reject, or destroy any object that is recognized as foreign organism inevitably mounts a reaction (FBR). Depending on its severity chronicity, FBR can impair implant performance create severe clinical complications will require surgical removal and/or replacement faulty device. The number review articles discussing seems be proportional different materials applications one wonders, what else there tell? We here take position fibrosis researcher (which, coincidentally, we are) elaborate similarities differences between FBR, normal wound healing, chronic healing conditions result in development peri-implant fibrosis. After giving credit macrophages inflammatory phase mainly focus activation fibroblastic cells into matrix-producing highly contractile myofibroblasts. While has been discussed consequence disturbed milieu direct myofibroblasts at surface less commonly considered. Thus, provide perspective how physical properties control myofibroblast actions accumulation stiff scar tissue. Because formation tissue around major reason for device failure extraction surgeries, providing surfaces with myofibroblast-suppressing features first step enhance acceptance functional lifetime. Alternative therapeutic targets are elements mechanotransduction machinery end brief overview such considered treatment other organ fibroses.

Language: Английский

---