Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(1)
Published: Oct. 10, 2023
Abstract
Hybridizing
biological
cells
with
man‐made
sensors
enable
the
detection
of
a
wide
range
weak
physiological
responses
high
specificity.
The
anterior
chamber
eye
(ACE)
is
an
ideal
transplantation
site
due
to
its
ocular
immune
privilege
and
optical
transparency,
which
superior
noninvasive
longitudinal
analyses
microtissues.
Engraftment
biohybrid
microstructures
in
ACE
may,
however,
be
affected
by
pupillary
response
dynamics.
Here,
sutureless
microstructures,
3D
printed
IP‐Visio
photoresin,
containing
precisely
localized
pancreatic
islet
mice
presented.
allow
mechanical
fixation
ACE,
independent
iris
After
transplantation,
islets
successfully
sustain
their
functionality
for
over
20
weeks
become
vascularized
despite
physical
separation
from
vessel
source
(iris)
immersion
low‐viscous
liquid
(aqueous
humor)
continuous
circulation
clearance.
This
approach
opens
new
perspectives
microtissue
advancing
monitoring
microtissue–host
interactions,
disease
modeling,
treatment
outcomes,
vascularization
engineered
tissues.
Biomimetics,
Journal Year:
2022,
Volume and Issue:
7(3), P. 87 - 87
Published: July 1, 2022
The
extracellular
matrix
(ECM)
is
a
3-dimensional
structure
and
an
essential
component
in
all
human
tissues.
It
comprised
of
varying
proteins,
including
collagens,
elastin,
smaller
quantities
structural
proteins.
Studies
have
demonstrated
the
ECM
aids
cellular
adherence,
tissue
anchoring,
signaling,
recruitment
cells.
During
times
integumentary
injury
or
damage,
either
acute
chronic,
damaged.
Through
series
overlapping
events
called
wound
healing
phases—hemostasis,
inflammation,
proliferation,
remodeling—the
synthesized
ideally
returned
to
its
native
state.
This
article
synthesizes
current
historical
literature
demonstrate
involvement
phases
cascade.
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(9), P. 2307 - 2307
Published: Sept. 16, 2022
Collagen
is
the
most
abundant
structural
protein
found
in
humans
and
mammals,
particularly
extracellular
matrix
(ECM).
Its
primary
function
to
hold
body
together.
The
collagen
superfamily
of
proteins
includes
over
20
types
that
have
been
identified.
Yet,
type
I
major
component
many
tissues
can
be
extracted
as
a
natural
biomaterial
for
various
medical
biological
purposes.
has
multiple
advantageous
characteristics,
including
varied
sources,
biocompatibility,
sustainability,
low
immunogenicity,
porosity,
biodegradability.
As
such,
collagen-type-I-based
bioscaffolds
widely
used
tissue
engineering.
Biomaterials
based
on
also
modified
improve
their
functions,
such
by
crosslinking
strengthen
mechanical
property
or
adding
biochemical
factors
enhance
activity.
This
review
discusses
complexities
structure,
biosynthesis,
sources
derivatives,
methods
isolation
purification,
physicochemical
current
development
scaffolds
engineering
applications.
advancement
additional
novel
engineered
bioproducts
with
refined
techniques
continuous
augmentation
facilitated
understanding
conventional
design
application
biomaterials
I.
Cold Spring Harbor Perspectives in Biology,
Journal Year:
2022,
Volume and Issue:
15(1), P. a041231 - a041231
Published: Sept. 19, 2022
Myofibroblasts
are
the
construction
workers
of
wound
healing
and
repair
damaged
tissues
by
producing
organizing
collagen/extracellular
matrix
(ECM)
into
scar
tissue.
Scar
tissue
effectively
quickly
restores
mechanical
integrity
lost
architecture
but
comes
at
price
functionality.
Fibrotic
diseases
caused
excessive
or
persistent
myofibroblast
activity
can
lead
to
organ
failure.
This
review
defines
terminology,
phenotypic
characteristics,
functions.
We
will
focus
on
central
role
cell,
ECM,
mechanics
in
regulating
controlling
action.
Additionally,
we
discuss
how
therapies
based
intervention
potentially
ameliorate
outcomes.
Although
physiology
pathology
affect
all
organs,
emphasize
cutaneous
hypertrophic
scarring
as
paradigms
for
normal
versus
fibrosis.
A
message
this
is
that
myofibroblasts
be
activated
from
multiple
cell
sources,
varying
with
local
environment
type
injury,
either
restore
function
create
an
inappropriate
environment.
Journal of Cell Science,
Journal Year:
2023,
Volume and Issue:
136(18)
Published: Sept. 15, 2023
ABSTRACT
Shear
stress
is
essential
for
normal
physiology
and
malignancy.
Common
physiological
processes
–
such
as
blood
flow,
particle
flow
in
the
gut,
or
contact
between
migratory
cell
clusters
their
substrate
produce
shear
that
can
have
an
impact
on
behavior
of
different
tissues.
In
addition,
has
roles
biomedical
interest,
wound
healing,
cancer
fibrosis
induced
by
soft
implants.
Thus,
understanding
how
cells
react
adapt
to
important.
this
Review,
we
discuss
vivo
vitro
data
obtained
from
vascular
epithelial
models;
highlight
insights
these
afforded
regarding
general
mechanisms
through
which
sense,
transduce
respond
at
cellular
levels;
outline
changes
experience
response
tissue
organization.
Finally,
role
collective
migration,
only
starting
be
appreciated.
We
review
our
current
effects
context
embryo
development,
fibrosis,
invite
scientific
community
further
investigate
scenarios.
Advanced Materials Interfaces,
Journal Year:
2023,
Volume and Issue:
10(12)
Published: March 10, 2023
Abstract
Poly(dimethylsiloxane)
(PDMS)
has
been
widely
employed
in
biomedical
disciplines
due
to
its
several
advantages,
including
biocompatibility,
nontoxicity,
and
low‐cost
preparation.
However,
the
intrinsic
hydrophobicity
of
this
material
encourages
biofouling
reduces
cell
regulation
capacity,
thereby
limiting
applicability.
The
purpose
study
is
explore
surface
modification
functionalization
PDMS
PDMS‐based
biomaterials
improve
their
properties
for
applications.
content
review
organized
based
on
physical
chemical
strategies
hydrophilicity
enhance
antibiofouling
immunomodulation
modulation
biomaterials.
Future
developments
area
are
also
discussed.
Materials,
Journal Year:
2023,
Volume and Issue:
16(12), P. 4267 - 4267
Published: June 8, 2023
This
article
provides
a
thorough
overview
of
the
available
resorbable
biomaterials
appropriate
for
producing
replacements
damaged
tissues.
In
addition,
their
various
properties
and
application
possibilities
are
discussed
as
well.
Biomaterials
fundamental
components
in
tissue
engineering
(TE)
scaffolds
play
critical
role.
They
need
to
exhibit
biocompatibility,
bioactivity,
biodegradability,
non-toxicity,
ensure
ability
function
effectively
with
an
host
response.
With
ongoing
research
advancements
medical
implants,
objective
this
review
is
explore
recently
developed
implantable
scaffold
materials
The
categorization
paper
includes
fossil-based
(e.g.,
PCL,
PVA,
PU,
PEG,
PPF),
natural
or
bio-based
HA,
PLA,
PHB,
PHBV,
chitosan,
fibrin,
collagen,
starch,
hydrogels),
hybrid
PCL/PLA,
PCL/PEG,
PLA/PEG,
PLA/PHB
PCL/collagen,
PCL/chitosan,
PCL/starch,
PLA/bioceramics).
these
both
hard
soft
TE
considered,
particular
focus
on
physicochemical,
mechanical,
biological
properties.
Furthermore,
interactions
between
immune
system
context
scaffold-driven
regeneration
discussed.
Additionally,
briefly
mentions
concept
situ
TE,
which
leverages
self-renewal
capacities
affected
tissues
highlights
crucial
role
played
by
biopolymer-based
strategy.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 21, 2024
Abstract
Periodontitis
is
a
chronic
inflammation
caused
by
bacterial
infection
and
intimately
associated
with
an
overactive
immune
response.
Biomaterials
are
being
utilized
more
frequently
in
periodontal
therapy
due
to
their
designability
unique
drug
delivery
system.
However,
local
systemic
response
reactions
driven
the
implantation
of
biomaterials
could
result
inflammation,
tissue
damage,
fibrosis,
which
end
up
failure
implantation.
Therefore,
immunological
adjustment
through
precise
design
can
reduce
host
reaction
while
eliminating
tissue's
long-term
It
important
note
that
macrophages
active
system
component
participate
progression
disease
intricate
polarization
mechanisms.
And
modulating
macrophage
designing
has
emerged
as
new
technique.
In
this
review,
we
discuss
role
periodontitis
typical
strategies
for
polarizing
biomaterials.
Subsequently,
challenges
potential
opportunities
using
manipulate
facilitate
regeneration.
Graphical
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(35), P. 8577 - 8604
Published: Jan. 1, 2024
Biosensors
integrated
into
closed-loop
systems
provide
patient-specific
adaptive
therapies.
These
advanced
devices
have
significant
potential
for
managing
chronic
conditions
by
continuously
adjusting
therapeutic
regimens
based
on
physiological
data.
