The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications DOI Creative Commons
Douglas B. Kell, Etheresia Pretorius

Biochemical Journal, Journal Year: 2022, Volume and Issue: 479(16), P. 1653 - 1708

Published: Aug. 31, 2022

Ischaemia-reperfusion (I-R) injury, initiated via bursts of reactive oxygen species produced during the reoxygenation phase following hypoxia, is well known in a variety acute circumstances. We argue here that I-R injury also underpins elements pathology chronic, inflammatory diseases, including rheumatoid arthritis, ME/CFS and, our chief focus and most proximally, Long COVID. Ischaemia may be fibrin amyloid microclot blockage capillaries, for instance as exercise started; reperfusion necessary corollary when it finishes. rehearse mechanistic evidence these occurrences here, terms their manifestation oxidative stress, hyperinflammation, mast cell activation, production marker metabolites related activities. Such microclot-based phenomena can explain both breathlessness/fatigue post-exertional malaise observed conditions, many other observables. The recognition processes implies, mechanistically, therapeutic benefit potentially to had from antioxidants, anti-inflammatories, iron chelators, suitable, safe fibrinolytics, and/or anti-clotting agents. review considerable existing consistent with this, biochemical mechanisms involved.

Language: Английский

Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics DOI Creative Commons
A. Chen, Ying Gong,

S. C. Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 1, 2025

Language: Английский

Citations

2
Antibiotic resistance in the commensal human gut microbiota DOI Creative Commons
Lisa E. Lamberte, Willem van Schaik

Current Opinion in Microbiology, Journal Year: 2022, Volume and Issue: 68, P. 102150 - 102150

Published: April 28, 2022

Antibiotic-resistant infections are a major threat to global public health and there is an urgent need develop new drugs interventions treat prevent caused by antibiotic-resistant bacteria. The human gut microbiota harbours both commensals opportunistic pathogens which can acquire resistance antibiotics through mutation horizontal gene transfer. powerful combination of modern high-throughput DNA sequencing microbiological culture methods providing novel insights into the mechanisms antibiotic among, up recently poorly studied, commensal bacteria in gut. Interventions minimise abundance include faecal transplantation use live biotherapeutics, but efficacy these treatments remains elusive.

Language: Английский

Citations

66
The neurovascular unit and systemic biology in stroke — implications for translation and treatment DOI
Steffen Tiedt, Alastair M. Buchan, Martin Dichgans

et al.

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(10), P. 597 - 612

Published: Sept. 9, 2022

Language: Английский

Citations

64
Plasmonic Nanozymes: Leveraging Localized Surface Plasmon Resonance to Boost the Enzyme‐Mimicking Activity of Nanomaterials DOI
Guopeng Xu, Xuancheng Du, Weijie Wang

et al.

Small, Journal Year: 2022, Volume and Issue: 18(49)

Published: Sept. 26, 2022

Abstract Nanozymes, a type of nanomaterials that function similarly to natural enzymes, receive extensive attention in biomedical fields. However, the widespread applications nanozymes are greatly plagued by their unsatisfactory enzyme‐mimicking activity. Localized surface plasmon resonance (LSPR), nanoscale physical phenomenon described as collective oscillation free electrons plasmonic nanoparticles under light irradiation, offers robust universal paradigm boost catalytic performance nanozymes. Plasmonic (PNzymes) with elevated activity leveraging LSPR, emerge and provide unprecedented opportunities for biocatalysis. In this review, mechanisms behind PNzymes thoroughly revealed including near‐field enhancement, hot carriers, photothermal effect. The rational design biosensing, cancer therapy, bacterial infections elimination systematically introduced. Current challenges further perspectives also summarized discussed stimulate clinical translation. It is hoped review can attract more researchers advance promising field open up new avenue optimizing create superior nanocatalysts applications.

Language: Английский

Citations

55
The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications DOI Creative Commons
Douglas B. Kell, Etheresia Pretorius

Biochemical Journal, Journal Year: 2022, Volume and Issue: 479(16), P. 1653 - 1708

Published: Aug. 31, 2022

Ischaemia-reperfusion (I-R) injury, initiated via bursts of reactive oxygen species produced during the reoxygenation phase following hypoxia, is well known in a variety acute circumstances. We argue here that I-R injury also underpins elements pathology chronic, inflammatory diseases, including rheumatoid arthritis, ME/CFS and, our chief focus and most proximally, Long COVID. Ischaemia may be fibrin amyloid microclot blockage capillaries, for instance as exercise started; reperfusion necessary corollary when it finishes. rehearse mechanistic evidence these occurrences here, terms their manifestation oxidative stress, hyperinflammation, mast cell activation, production marker metabolites related activities. Such microclot-based phenomena can explain both breathlessness/fatigue post-exertional malaise observed conditions, many other observables. The recognition processes implies, mechanistically, therapeutic benefit potentially to had from antioxidants, anti-inflammatories, iron chelators, suitable, safe fibrinolytics, and/or anti-clotting agents. review considerable existing consistent with this, biochemical mechanisms involved.

Language: Английский

Citations

52