Injury to thalamocortical projections following traumatic brain injury results in attractor dynamics for cortical networks DOI Creative Commons
Sima Mofakham, Yuhao Liu,

Asher A. Hensley

et al.

Progress in Neurobiology, Journal Year: 2022, Volume and Issue: 210, P. 102215 - 102215

Published: Jan. 4, 2022

Major theories of consciousness predict that complex electroencephalographic (EEG) activity is required for consciousness, yet it not clear how such arises in the corticothalamic system. The thalamus well-known to control cortical excitability via interlaminar projections, but whether thalamic input needed complexity known. We hypothesized facilitates by adjusting synaptic connectivity, thereby increasing availability different configurations neurons (cortical “states”), as well probability state transitions. To test this hypothesis, we characterized EEG from prefrontal cortex (PFC) traumatic brain injury (TBI) patients with and without injuries thalamocortical measured diffusion tensor imaging (DTI). found projections (especially mediodorsal thalamus) was strongly associated unconsciousness delta-band activity. Using advanced signal processing techniques, lack led 1.) attractor dynamics networks a tendency visit same states, 2.) reduced repertoire possible 3.) high predictability transitions between states. These results imply PFC depends on input. Our model implies restoration connectivity critical function after injury. draw connection consciousness.

Language: Английский

The impact of the human thalamus on brain-wide information processing DOI
James M. Shine, Laura D. Lewis, Douglas D. Garrett

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(7), P. 416 - 430

Published: May 26, 2023

Language: Английский

Citations

130
Thalamic subnetworks as units of function DOI
Dheeraj S. Roy, Ying Zhang, Michael M. Halassa

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(2), P. 140 - 153

Published: Jan. 31, 2022

Language: Английский

Citations

117
Paradoxical somatodendritic decoupling supports cortical plasticity during REM sleep DOI Open Access
Mattia Aime, Niccolò Calcini, Micaela Borsa

et al.

Science, Journal Year: 2022, Volume and Issue: 376(6594), P. 724 - 730

Published: May 12, 2022

Rapid eye movement (REM) sleep is associated with the consolidation of emotional memories. Yet, underlying neocortical circuits and synaptic mechanisms remain unclear. We found that REM a somatodendritic decoupling in pyramidal neurons prefrontal cortex. This reflects shift inhibitory balance between parvalbumin neuron-mediated somatic inhibition vasoactive intestinal peptide-mediated dendritic disinhibition, mostly driven by from central medial thalamus. REM-specific optogenetic suppression activity led to loss danger-versus-safety discrimination during associative learning lack plasticity, whereas release resulted enhanced potentiation. Somatodendritic promotes opposite plasticity optimize responses future behavioral stressors.

Language: Английский

Citations

73
Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective DOI Creative Commons
Ileana L. Hanganu‐Opatz, Thomas Klausberger, Torfi Sigurdsson

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1020 - 1036

Published: April 1, 2023

Language: Английский

Citations

51
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study DOI
Nicholas D. Schiff, Joseph T. Giacino, Christopher R. Butson

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(12), P. 3162 - 3174

Published: Dec. 1, 2023

Language: Английский

Citations

50
The mediodorsal thalamus in executive control DOI
Mathieu Wolff, Michael M. Halassa

Neuron, Journal Year: 2024, Volume and Issue: 112(6), P. 893 - 908

Published: Jan. 30, 2024

Language: Английский

Citations

22
Cognitive Control as a Multivariate Optimization Problem DOI
Harrison Ritz, Xiamin Leng, Amitai Shenhav

et al.

Journal of Cognitive Neuroscience, Journal Year: 2022, Volume and Issue: 34(4), P. 569 - 591

Published: Jan. 21, 2022

A hallmark of adaptation in humans and other animals is our ability to control how we think behave across different settings. Research has characterized the various forms cognitive can take-including enhancement goal-relevant information, suppression goal-irrelevant overall inhibition potential responses-and identified computations neural circuits that underpin this multitude types. Studies have also a wide range situations elicit adjustments allocation (e.g., those eliciting signals indicating an error or increased processing conflict), but rules governing when given situation will give rise adjustment remain poorly understood. Significant progress recently been made on front by casting as decision-making problem. This approach developed unifying normative models prescribe change incentives task demands result changes form control. Despite their successes, these models, experiments test them, yet face greatest challenge: deciding select among multiplicity configurations take at any time. Here, lay out complexities inverse problem inherent allocation, close parallels problems within motor choosing between redundant limb movements). We discuss existing solutions control's drawn from optimal theory, which proposed effort costs act regularize actions transform planning into well-posed These same principles may help shed light brains optimize over complex configuration, while providing new perspective origins mental effort.

Language: Английский

Citations

44
Neuroscience and architecture: Modulating behavior through sensorimotor responses to the built environment DOI Creative Commons
Zakaria Djebbara, Ole B. Jensen, Francisco J. Parada

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 138, P. 104715 - 104715

Published: May 30, 2022

As we move through the world, natural and built environments implicitly guide behavior by appealing to certain sensory motor dynamics. This process can be motivated automatic attention environmental features that resonate with specific sensorimotor responses. review aims at providing a psychobiological framework describing how lead automated responses defined neurophysiological mechanisms underlying attention. Through use of processes in subsets cortical structures, goal this is describe on neuronal level functional link between designed environment By distinguishing elaborate employs for adaptation. realized thalamo-cortical network integrating aspects behavior. We highlight transthalamic transmission from an Enactive predictive perspective recent studies effectively modulated systematically manipulating features. end suggesting promising combination neuroimaging computational analysis future studies.

Language: Английский

Citations

43
Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner DOI Creative Commons
Katharina Ziegler,

Ross Folkard,

Antonio J. González

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 24, 2023

The primary somatosensory cortex (S1) is a hub for body sensation of both innocuous and noxious signals, yet its role in somatosensation versus pain debated. Despite known contributions S1 to sensory gain modulation, causal involvement subjective experiences remains elusive. Here, mouse S1, we reveal the cortical output neurons layers 5 (L5) 6 (L6) perception signals. We find that L6 activation can drive aversive hypersensitivity spontaneous nocifensive behavior. Linking behavior neuronal mechanisms, enhances thalamic responses, parallel, strongly suppresses L5 neurons. Directly suppressing reproduced pronociceptive phenotype induced by activation, suggesting an anti-nociceptive function output. Indeed, reduced sensitivity reversed inflammatory allodynia. Together, these findings layer-specific bidirectional modulating experiences.

Language: Английский

Citations

34
Molecular and spatial profiling of the paraventricular nucleus of the thalamus DOI Creative Commons
Claire Gao, Chiraag Gohel, Yan Leng

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 3, 2023

The paraventricular nucleus of the thalamus (PVT) is known to regulate various cognitive and behavioral processes. However, while functional diversity among PVT circuits has often been linked cellular differences, molecular identity spatial distribution cell types remain unclear. To address this gap, here we used single RNA sequencing (snRNA-seq) identified five molecularly distinct neuronal subtypes in mouse brain. Additionally, multiplex fluorescent situ hybridization top marker genes revealed that are organized by a combination previously unidentified gradients. Lastly, comparing our dataset with recently published single-cell atlas yielded novel insight into PVT’s connectivity cortex, including unexpected innervation auditory visual areas. This comparison also data contains largely non-overlapping transcriptomic map multiple midline thalamic nuclei. Collectively, findings uncover unknown features anatomical organization provide valuable resource for future investigations.

Language: Английский

Citations

26