Transboundary and Emerging Diseases,
Journal Year:
2022,
Volume and Issue:
69(6), P. 3181 - 3197
Published: Oct. 11, 2022
The
novel
coronavirus
disease
(COVID-19)
outbreak
that
emerged
at
the
end
of
2019
has
now
swept
world
for
more
than
2
years,
causing
immeasurable
damage
to
lives
and
economies
world.
It
drawn
so
much
attention
discovering
how
severe
acute
respiratory
syndrome
(SARS-CoV-2)
originated
entered
human
body.
current
argument
revolves
around
two
contradictory
theories:
a
scenario
laboratory
spillover
events
contact
with
zoonotic
diseases.
Here,
we
reviewed
transmission,
pathogenesis,
possible
hosts,
as
well
genome
protein
structure
SARS-CoV-2,
which
play
key
roles
in
COVID-19
pandemic.
We
believe
was
originally
transmitted
by
animals
rather
leak.
However,
there
still
needs
investigations
determine
source
Understanding
is
vital
developing
global
strategies
mitigating
future
outbreaks.
Nucleic Acids Research,
Journal Year:
2022,
Volume and Issue:
51(2), P. 783 - 795
Published: Dec. 13, 2022
The
number
of
genetic
variations
in
the
SARS-CoV-2
genome
has
been
increasing
primarily
due
to
continuous
viral
mutations.
Here,
we
report
that
human
APOBEC3A
(A3A)
cytidine
deaminase
plays
a
critical
role
induction
C-to-U
substitutions
genome.
Bioinformatic
analysis
chronological
changes
sequence
database
indicated
largest
UC-to-UU
mutation
signature,
consistent
with
APOBEC-recognized
nucleotide
motifs,
was
predominant
single-stranded
RNA
regions
In
SARS-CoV-2-infected
cells,
exogenous
expression
A3A
but
not
other
APOBEC
proteins
induced
mutations
(vRNA).
Additionally,
mutated
C
bases
were
often
located
at
tips
bulge
or
loop
vRNA
secondary
structure.
Interestingly,
mRNA
drastically
increased
by
interferons
(IFNs)
and
tumour
necrosis
factor-α
(TNF-α)
epithelial
cells
derived
from
respiratory
system,
site
efficient
replication.
Moreover,
rate
produced
lung
treated
IFN-ß
TNF-α,
CRISPR/Cas9-based
knockout
cells.
Collectively,
these
findings
demonstrate
is
primary
host
factor
drives
via
editing.
Research Square (Research Square),
Journal Year:
2022,
Volume and Issue:
unknown
Published: Feb. 25, 2022
Abstract
Emerging
in
December
2019,
coronavirus
disease
2019
(COVID-19)
eventually
became
a
pandemic
and
has
posed
tremendous
threat
to
global
public
health.
However,
the
origins
of
SARS-CoV-2,
causative
agent
COVID-19,
remain
be
determined.
It
reported
that
certain
number
early
case
clusters
had
contact
history
with
Huanan
Seafood
Market.
Therefore,
surveillance
SARS-CoV-2
within
market
is
vital
importance.
Herein,
we
presented
detection
results
1380
samples
collected
from
environment
animals
2020.
By
SARS-CoV-2-specific
RT-qPCR,
73
environmental
tested
positive
for
three
live
viruses
were
successfully
isolated.
The
shared
nucleotide
identity
99.980%
99.993%
human
isolate
HCoV/Wuhan/IVDC-HB-01.
In
contrast,
no
virus
was
detected
animal
swabs
covering
18
species
market.
SARS-COV-2
nucleic
acids
showed
significant
correlation
abundance
Homo
sapiens
SARS-CoV-2.
summary,
this
study
provided
convincing
evidence
prevalence
Market
during
stage
COVID-19
outbreak.
Life,
Journal Year:
2022,
Volume and Issue:
12(2), P. 194 - 194
Published: Jan. 28, 2022
The
COVID-19
pandemic
has
had
a
significant
global
impact,
with
more
than
280,000,000
people
infected
and
5,400,000
deaths.
use
of
personal
protective
equipment
the
anti-SARS-CoV-2
vaccination
campaigns
have
reduced
infection
death
rates
worldwide.
However,
recent
increase
in
been
observed
associated
appearance
SARS-CoV-2
variants,
including
recently
described
lineage
B.1.617.2
(Delta
variant)
B.1.1.529/BA.1
(Omicron
variant).
These
new
variants
put
effectiveness
international
at
risk,
outbreaks
throughout
world.
This
emergence
due
to
multiple
predisposing
factors,
molecular
characteristics
virus,
geographic
environmental
conditions,
impact
social
determinants
health
that
favor
genetic
diversification
SARS-CoV-2.
We
present
literature
review
on
most
information
available
analyzed
biological,
geographical,
sociocultural
factors
development
these
variants.
Finally,
we
evaluate
surveillance
strategies
for
early
detection
prevent
their
distribution
outside
regions.
Transboundary and Emerging Diseases,
Journal Year:
2022,
Volume and Issue:
69(6), P. 3181 - 3197
Published: Oct. 11, 2022
The
novel
coronavirus
disease
(COVID-19)
outbreak
that
emerged
at
the
end
of
2019
has
now
swept
world
for
more
than
2
years,
causing
immeasurable
damage
to
lives
and
economies
world.
It
drawn
so
much
attention
discovering
how
severe
acute
respiratory
syndrome
(SARS-CoV-2)
originated
entered
human
body.
current
argument
revolves
around
two
contradictory
theories:
a
scenario
laboratory
spillover
events
contact
with
zoonotic
diseases.
Here,
we
reviewed
transmission,
pathogenesis,
possible
hosts,
as
well
genome
protein
structure
SARS-CoV-2,
which
play
key
roles
in
COVID-19
pandemic.
We
believe
was
originally
transmitted
by
animals
rather
leak.
However,
there
still
needs
investigations
determine
source
Understanding
is
vital
developing
global
strategies
mitigating
future
outbreaks.
