The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic

Science, Journal Year: 2022, Volume and Issue: 377(6609), P. 951 - 959

Published: July 26, 2022

Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 is critical to preventing future zoonotic outbreaks before they become the next pandemic. The Huanan Seafood Wholesale Market Wuhan, China, was identified as a likely source of cases early reports, but later this conclusion became controversial. We show here that earliest known COVID-19 from December 2019, including those without reported direct links, were geographically centered on market. report live SARS-CoV-2–susceptible mammals sold at market late and within market, SARS-CoV-2–positive environmental samples spatially associated with vendors selling mammals. Although there insufficient evidence define upstream events, exact circumstances remain obscure, our analyses indicate emergence SARS-CoV-2 occurred through wildlife trade China epicenter

Language: Английский

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Two Years into the COVID-19 Pandemic: Lessons Learned

ACS Infectious Diseases, Journal Year: 2022, Volume and Issue: 8(9), P. 1758 - 1814

Published: Aug. 8, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and virulent human-infecting that emerged in late December 2019 Wuhan, China, causing disease called (COVID-19), which has massively impacted global public health caused widespread disruption to daily life. The crisis by COVID-19 mobilized scientists authorities across the world rapidly improve our knowledge about this devastating disease, shedding light on its management control, spawned development of new countermeasures. Here we provide an overview state art gained last years virus COVID-19, including origin natural reservoir hosts, viral etiology, epidemiology, modes transmission, clinical manifestations, pathophysiology, diagnosis, treatment, prevention, emerging variants, vaccines, highlighting important differences from previously known pathogenic coronaviruses. We also discuss selected key discoveries each topic underline gaps for future investigations.

Language: Английский

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Wuhan market was epicentre of pandemic’s start, studies suggest

Nature, Journal Year: 2022, Volume and Issue: 603(7899), P. 15 - 16

Published: Feb. 27, 2022

Language: Английский

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The origins of COVID‐19 pandemic: A brief overview

Transboundary and Emerging Diseases, Journal Year: 2022, Volume and Issue: 69(6), P. 3181 - 3197

Published: Oct. 11, 2022

The novel coronavirus disease (COVID-19) outbreak that emerged at the end of 2019 has now swept world for more than 2 years, causing immeasurable damage to lives and economies world. It drawn so much attention discovering how severe acute respiratory syndrome (SARS-CoV-2) originated entered human body. current argument revolves around two contradictory theories: a scenario laboratory spillover events contact with zoonotic diseases. Here, we reviewed transmission, pathogenesis, possible hosts, as well genome protein structure SARS-CoV-2, which play key roles in COVID-19 pandemic. We believe was originally transmitted by animals rather leak. However, there still needs investigations determine source Understanding is vital developing global strategies mitigating future outbreaks.

Language: Английский

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The impact of monetary policy interventions on banking sector stocks: an empirical investigation of the COVID-19 crisis

Financial Innovation, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 30, 2024

Abstract The enduring impact of the COVID-19 crisis on financial sector is undeniable, persisting far beyond eventual waning pandemic. This research examines central bank interventions during pandemic, using a quantitative event study approach over five-day window to analyse 188 monetary policy announcements banking stocks in China, U.S., and Europe. Our results demonstrate how targeting different economic mechanisms have produced diverse market reaction throughout Namely, cuts interest rates maintenance low rate environment by Federal Reserve resulted negative abnormal returns U.S.A., while short-term surrounding intra-day credit liquidity provisions boosted stock prices. In Europe, muted was observed, with observed response ECB’s 2% inflation objectives. Finally, China responded strongly positively foreign currency exchange-related People’s Bank China. insights from this analysis can thus inform preparations made policymakers, governments, stakeholders future waves COVID-19, or further extreme societal disruptions.

Language: Английский

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Coronaviruses in wild animals sampled in and around Wuhan at the beginning of COVID-19 emergence

Virus Evolution, Journal Year: 2022, Volume and Issue: 8(1)

Published: Jan. 1, 2022

Over the last several decades, no emerging virus has had a profound impact on world as SARS-CoV-2 that emerged at end of 2019 done. To know where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated from and how it jumped into human population, we immediately started surveillance investigation in wild mammals around Wuhan when determined agent. Herein, coronaviruses were screened lung, liver, intestinal tissue samples fifteen raccoon dogs, seven Siberian weasels, three hog badgers, Reeves's muntjacs collected 334 bats Wuhan. Consequently, eight alphacoronaviruses identified while nine betacoronaviruses found bats. Notably, newly discovered shared high whole-genome sequence similarity (97.9 per cent) with canine (CCoV) strain 2020/7 sampled domestic dog UK. Some here closely related to previously known bat SARS-CoV-related viruses Hubei province its neighbors, remaining exhibited close evolutionary relationship RdRp gene tree clustered together SARS-CoV-2-related M, N S trees, but relatively low similarity. Additionally, these seem unlikely bind angiotensin-converting enzyme because deletions two key regions their receptor-binding motifs. Finally, did not find or progenitor animal samples. Due circulation CCoVs dogs Wuhan, more scientific efforts are warranted better understand diversity evolution China possibility potential

Language: Английский

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COVID-origins study links raccoon dogs to Wuhan market: what scientists think

Nature, Journal Year: 2023, Volume and Issue: 615(7954), P. 771 - 772

Published: March 21, 2023

Language: Английский

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Scientists struggle to probe COVID’s origins amid sparse data from China

Nature, Journal Year: 2022, Volume and Issue: 603(7903), P. 773 - 775

Published: March 17, 2022

Language: Английский

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The evidence remains clear: SARS-CoV-2 emerged via the wildlife trade

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(47)

Published: Nov. 10, 2022

Mutations are important because they provide raw material for evolution. Some types of mutations occur more often than others, and the strength such mutational bias varies across species. It is not clear how this variation arises. We ...Biased mutation spectra pervasive, with wide in magnitude biases that influence genome evolution adaptation. How do diverse evolve? Our experiments show changing spectrum allows populations ...

Language: Английский

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Human coronaviruses: The emergence of SARS-CoV-2 and management of COVID-19

Virus Research, Journal Year: 2022, Volume and Issue: 319, P. 198882 - 198882

Published: Aug. 4, 2022

Language: Английский

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