Non-canonical odor coding in the mosquito

Cell, Journal Year: 2022, Volume and Issue: 185(17), P. 3104 - 3123.e28

Published: Aug. 1, 2022

Aedes aegypti mosquitoes are a persistent human foe, transmitting arboviruses including dengue when they feed on blood. Mosquitoes intensely attracted to body odor and carbon dioxide, which detect using ionotropic chemosensory receptors encoded by three large multi-gene families. Genetic mutations that disrupt the olfactory system have modest effects attraction, suggesting redundancy in coding. The canonical view is sensory neurons each express single receptor defines its ligand selectivity. We discovered Ae. uses different organizational principle, with many co-expressing multiple genes. In vivo electrophysiology demonstrates broad ligand-sensitivity of mosquito depends this non-canonical co-expression. afforded an co-express may increase robustness explain our long-standing inability detection humans mosquitoes.

Language: Английский

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Effects of climate change and human activities on vector-borne diseases

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(8), P. 476 - 491

Published: March 14, 2024

Language: Английский

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Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels

Cell, Journal Year: 2022, Volume and Issue: 185(22), P. 4099 - 4116.e13

Published: Oct. 1, 2022

Some people are more attractive to mosquitoes than others, but the mechanistic basis of this phenomenon is poorly understood. We tested mosquito attraction human skin odor and identified who exceptionally or unattractive mosquitoes. These differences were stable over several years. Chemical analysis revealed that highly produce significantly carboxylic acids in their emanations. Mutant lacking chemosensory co-receptors Ir8a, Ir25a, Ir76b severely impaired scent, retained ability differentiate weakly people. The link between elevated "mosquito-magnet" phenotypes genetic mutations acid receptors suggests such compounds contribute differential attraction. Understanding why some humans others provides insights into what odorants most important could inform development effective repellents.

Language: Английский

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Cross-modal sensory compensation increases mosquito attraction to humans

Science Advances, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 1, 2025

Sensory compensation occurs when loss of one sense leads to enhanced perception by another sense. We have identified a previously undescribed mechanism sensory in female Aedes aegypti mosquitoes. Odorant receptor co-receptor ( Orco ) mutants show attraction human skin temperature and increased heat-evoked neuronal activity foreleg neurons. Ir140 , foreleg-enriched member the ionotropic (IR) superfamily receptors, is up-regulated mutant legs. double do not heat seeking seen single mutants, suggesting that up-regulation key underlying mutants. Because expression sparse legs, this requires an indirect, long-range mechanism. Our findings highlight how mosquitoes, despite suffering olfactory loss, maintain overall effectiveness their host-seeking behavior up-regulating temperature, further enhancing status as most dangerous predator humans.

Language: Английский

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Highly sensitive, scrub-resistant, robust breathable wearable silk yarn sensors via interfacial multiple covalent reactions for health management

Nano Energy, Journal Year: 2023, Volume and Issue: 115, P. 108723 - 108723

Published: July 17, 2023

Language: Английский

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Biology and Behaviour of Aedes aegypti in the Human Environment: Opportunities for Vector Control of Arbovirus Transmission

Viruses, Journal Year: 2023, Volume and Issue: 15(3), P. 636 - 636

Published: Feb. 27, 2023

is a ubiquitous vector of arboviruses mostly in urbanised areas throughout the tropics and subtropics growing threat beyond. Control

Language: Английский

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Retina‐Inspired Nanofluidic Membranes for Underwater Visual Imaging Based on Active Ion Transport

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: March 30, 2024

Abstract Through evolution, biological organisms have developed ways to sense light using ion channels, which holds several advantages, such as energy efficiency and water resistance, over humanmade optoelectronic devices. Herein, a retina‐inspired nanofluidic system is presented with Janus heterogeneous membrane (J‐HM), can achieve underwater visual imaging through light‐driven active transport. The J‐HMs are obtained sequentially assembled WS 2 , kind of metal–organic framework nanosheets via the reaction between 2,3,6,7,10,11‐hexahydroxytriphenylene hydrate (HHTP) Cu 2+ (Cu‐HHTP). Due formed intramembrane electric field caused by efficient charge separation under illumination, photovoltaic driving force generated for transport from Cu‐HHTP . Furthermore, unidirectionally be enhanced self‐diffusion concentration gradient. J‐HM single‐pixel design shows nearly linear response intensity has enough resolution basic object recognition well long‐term memory after data processing defined pixelated matrix, pave an avenue designing more intelligent sensing systems.

Language: Английский

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Sparse and stereotyped encoding implicates a core glomerulus for ant alarm behavior

Cell, Journal Year: 2023, Volume and Issue: 186(14), P. 3079 - 3094.e17

Published: June 15, 2023

Ants communicate via large arrays of pheromones and possess expanded, highly complex olfactory systems, with antennal lobes in the brain comprising up to ∼500 glomeruli. This expansion implies that odors could activate hundreds glomeruli, which would pose challenges for higher-order processing. To study this problem, we generated transgenic ants expressing genetically encoded calcium indicator GCaMP sensory neurons. Using two-photon imaging, mapped complete glomerular responses four ant alarm pheromones. Alarm robustly activated ≤6 activity maps three inducing panic our species converged on a single glomerulus. These results demonstrate that, rather than using broadly tuned combinatorial encoding, employ precise, narrowly tuned, stereotyped representations The identification central hub glomerulus behavior suggests simple neural architecture is sufficient translate pheromone perception into behavioral outputs.

Language: Английский

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Sebaceous origins of human odor

Current Biology, Journal Year: 2025, Volume and Issue: 35(8), P. R303 - R313

Published: April 1, 2025

Language: Английский

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Chemical Ecology and Management of Dengue Vectors

Annual Review of Entomology, Journal Year: 2023, Volume and Issue: 69(1), P. 159 - 182

Published: Aug. 25, 2023

Dengue, caused by the dengue virus, is most widespread arboviral infectious disease of public health significance globally. This review explores communicative function olfactory cues that mediate host-seeking, egg-laying, plant-feeding, and mating behaviors in

Language: Английский

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