Metastasis

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1564 - 1579

Published: April 1, 2023

Language: Английский

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Metabolic programming and immune suppression in the tumor microenvironment

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 421 - 433

Published: Feb. 16, 2023

Language: Английский

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Biology, vulnerabilities and clinical applications of circulating tumour cells

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 23(2), P. 95 - 111

Published: Dec. 9, 2022

Language: Английский

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What is cancer metabolism?

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1670 - 1688

Published: Feb. 28, 2023

Language: Английский

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Cancer cell plasticity during tumor progression, metastasis and response to therapy

Nature Cancer, Journal Year: 2023, Volume and Issue: 4(8), P. 1063 - 1082

Published: Aug. 3, 2023

Language: Английский

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Emerging therapies in cancer metabolism

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(8), P. 1283 - 1303

Published: Aug. 1, 2023

Language: Английский

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The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

Nature Reviews Genetics, Journal Year: 2023, Volume and Issue: 24(9), P. 590 - 609

Published: May 11, 2023

Language: Английский

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PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 23, 2023

Abstract Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, using integrative metabolomics transcriptomics analyses, we show a heterogeneity between metabolite transcript profiles. Specifically, the level of serine hepatocellular carcinoma (HCC) tissues increased, whereas expression phosphoglycerate dehydrogenase (PHGDH), first rate-limiting enzyme biosynthesis pathway, markedly downregulated. Interestingly, increased obtained by enhanced PHGDH catalytic activity due to protein arginine methyltransferase 1 (PRMT1)-mediated methylation at 236. PRMT1-mediated activation potentiates synthesis, ameliorates oxidative stress, promotes HCC vitro vivo. Furthermore, correlates with hyperactivation accumulation human tissues, predictive poor prognosis patients. Notably, blocking TAT-tagged nonmethylated peptide inhibits restrains an patient-derived xenograft (PDX) model subcutaneous cell-derived model. Overall, our findings reveal suggest as potential therapeutic vulnerability HCC.

Language: Английский

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Metabolic heterogeneity in cancer

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(1), P. 18 - 38

Published: Jan. 24, 2024

Language: Английский

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Glycosylation: mechanisms, biological functions and clinical implications

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 5, 2024

Protein post-translational modification (PTM) is a covalent process that occurs in proteins during or after translation through the addition removal of one more functional groups, and has profound effect on protein function. Glycosylation most common PTMs, which polysaccharides are transferred to specific amino acid residues by glycosyltransferases. A growing body evidence suggests glycosylation essential for unfolding various activities organisms, such as playing key role regulation function, cell adhesion immune escape. Aberrant also closely associated with development diseases. Abnormal patterns linked emergence health conditions, including cancer, inflammation, autoimmune disorders, several other However, underlying composition structure glycosylated have not been determined. It imperative fully understand internal differential expression glycosylation, incorporate advanced detection technologies keep knowledge advancing. Investigations clinical applications focused sensitive promising biomarkers, effective small molecule targeted drugs emerging vaccines. These studies provide new area novel therapeutic strategies based glycosylation.

Language: Английский

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