Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
Depression
represents
a
prevalent
and
enduring
mental
disorder
of
significant
concern
within
the
clinical
domain.
Extensive
research
indicates
that
depression
is
very
complex,
with
many
interconnected
pathways
involved.
Most
related
to
focuses
on
monoamines,
neurotrophic
factors,
hypothalamic-pituitary-adrenal
axis,
tryptophan
metabolism,
energy
mitochondrial
function,
gut-brain
glial
cell-mediated
inflammation,
myelination,
homeostasis,
brain
neural
networks.
However,
recently,
Ketamine,
an
ionotropic
N-methyl-D-aspartate
(NMDA)
receptor
antagonist,
has
been
discovered
have
rapid
antidepressant
effects
in
patients,
leading
novel
successful
treatment
approaches
for
mood
disorders.
This
review
aims
summarize
latest
findings
insights
into
various
signaling
systems
observed
patients
animal
models,
providing
more
comprehensive
view
neurobiology
anxious-depressive-like
behavior.
Specifically,
it
highlights
key
mechanisms
ketamine
as
rapid-acting
antidepressant,
aiming
enhance
neuropsychiatric
Moreover,
we
discuss
potential
prophylactic
or
therapeutic
intervention
stress-related
psychiatric
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(12)
Published: March 19, 2025
High-throughput
production
of
monodisperse
microdroplets
has
revolutionized
many
fields,
typically
relying
on
shear-induced
emulsification
in
intricate
microfluidic
channels
to
induce
the
Rayleigh-Plateau
instability.
This
mechanism
exhibits
low
robustness
due
its
high
dependence
physical
properties
and
flow
conditions
fluids.
Here,
we
report
a
robust
mechanism—wetting-induced
interfacial
instability—for
droplet
emission.
We
find
that,
when
pendant
air
contact
with
an
immiscible
wetting
bulk
phase,
it
triggers
instability
hanging
droplets
then
their
rapid
breakup
into
phase.
simplifies
microdroplet
using
nozzle
positioned
above
air-liquid
interface,
requiring
no
complex
microchannels.
demonstrate
that
this
method
highly
scalable
exceptional
against
variations
fluids,
including
viscous
non-Newtonian
fluid
(56,600
millipascal-seconds).
provides
simpler
alternative
traditional
for
emulsification,
offering
opportunities
industrial
applications
insights
microscale
science.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4167 - 4167
Published: April 28, 2025
Soluble
oligomeric
forms
of
Amyloid-β
(Aβ)
are
considered
the
major
toxic
species
leading
to
neurodegeneration
underlying
Alzheimer’s
disease
(AD).
Therefore,
drugs
that
prevent
oligomer
formation
might
be
promising.
The
atypical
dipeptide
GAL-201
is
orally
bioavailable
and
interferes
as
a
modulator
Aβ
aggregation.
It
binds
aggregation-prone,
misfolded
monomers
with
high
selectivity
affinity,
thereby
preventing
oligomers.
Here,
we
demonstrate
previously
observed
protective
effect
on
synaptic
plasticity
occurs
irrespective
shortages
post-translational
modifications
(tested
isoforms:
Aβ1–42,
Aβ(p3-42),
Aβ1–40
3NTyr(10)-Aβ).
Interestingly,
neuroprotective
activity
single
dose
was
still
present
after
one
week
correlated
prevention
Aβ-induced
spine
loss.
Furthermore,
could
observe
beneficial
effects
morphology
well
significantly
reduced
activation
proinflammatory
microglia
astrocytes
in
presence
an
Aβ1–42-derived
toxicity.
In
line
these
vitro
data,
additionally
improved
hippocampus-dependent
spatial
learning
“tgArcSwe”
AD
mouse
model
subcutaneous
administration.
By
this
means,
changes
deposition
pattern:
through
clustering
off-pathway
non-toxic
agglomerates,
oligomers
removed.
Our
results
collected
preclinical
data
warrant
initiation
Investigational
New
Drug
(IND)-enabling
studies
for
GAL-201.
demonstrating
highly
efficient
detoxification
β-sheet
monomers,
neutralization
toxicity,
represents
promising
drug
candidate
against
Aβ-derived
pathophysiology
AD.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
Depression
represents
a
prevalent
and
enduring
mental
disorder
of
significant
concern
within
the
clinical
domain.
Extensive
research
indicates
that
depression
is
very
complex,
with
many
interconnected
pathways
involved.
Most
related
to
focuses
on
monoamines,
neurotrophic
factors,
hypothalamic-pituitary-adrenal
axis,
tryptophan
metabolism,
energy
mitochondrial
function,
gut-brain
glial
cell-mediated
inflammation,
myelination,
homeostasis,
brain
neural
networks.
However,
recently,
Ketamine,
an
ionotropic
N-methyl-D-aspartate
(NMDA)
receptor
antagonist,
has
been
discovered
have
rapid
antidepressant
effects
in
patients,
leading
novel
successful
treatment
approaches
for
mood
disorders.
This
review
aims
summarize
latest
findings
insights
into
various
signaling
systems
observed
patients
animal
models,
providing
more
comprehensive
view
neurobiology
anxious-depressive-like
behavior.
Specifically,
it
highlights
key
mechanisms
ketamine
as
rapid-acting
antidepressant,
aiming
enhance
neuropsychiatric
Moreover,
we
discuss
potential
prophylactic
or
therapeutic
intervention
stress-related
psychiatric
