Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 21, 2025
Targeted
protein
delivery
with
nanocarriers
holds
significant
potential
to
enhance
therapeutic
outcomes
by
precisely
directing
proteins
specific
organs
or
tissues.
However,
the
complex
interactions
between
and
biological
environment
pose
considerable
challenges
in
designing
effective
targeted
vehicles.
In
this
study,
we
address
challenge
leveraging
DNA-barcoded
high-throughput
screening.
We
construct
a
nanocapsule
library
via
in-situ
polymerization,
incorporating
various
monomers
create
nanocapsules
unique
surface
properties.
vitro
vivo
screening,
using
female
mice,
identify
high
cell
association
different
biodistribution.
Our
investigation
into
kidney-enriched
highlights
crucial
role
of
polymer
composition
biodistribution,
demonstrating
engineering
for
precise
control
over
nanoparticle
distribution.
The
successfully
delivers
catalase,
showcasing
its
mitigating
cisplatin-induced
acute
kidney
injury.
Overall,
our
study
presents
an
approach
identifying
vehicles,
capacity
broaden
application
as
agents
research
tools.
development
requires
methods
screening
vivo.
Here
authors
develop
method
biodistributions,
demonstrate
catalase
kidneys
Nature,
Journal Year:
2024,
Volume and Issue:
630(8016), P. 493 - 500
Published: May 8, 2024
Abstract
The
introduction
of
AlphaFold
2
1
has
spurred
a
revolution
in
modelling
the
structure
proteins
and
their
interactions,
enabling
huge
range
applications
protein
design
2–6
.
Here
we
describe
our
3
model
with
substantially
updated
diffusion-based
architecture
that
is
capable
predicting
joint
complexes
including
proteins,
nucleic
acids,
small
molecules,
ions
modified
residues.
new
demonstrates
improved
accuracy
over
many
previous
specialized
tools:
far
greater
for
protein–ligand
interactions
compared
state-of-the-art
docking
tools,
much
higher
protein–nucleic
acid
nucleic-acid-specific
predictors
antibody–antigen
prediction
AlphaFold-Multimer
v.2.3
7,8
Together,
these
results
show
high-accuracy
across
biomolecular
space
possible
within
single
unified
deep-learning
framework.
Cell,
Journal Year:
2024,
Volume and Issue:
187(5), P. 1076 - 1100
Published: Feb. 1, 2024
Genome
editing
has
been
a
transformative
force
in
the
life
sciences
and
human
medicine,
offering
unprecedented
opportunities
to
dissect
complex
biological
processes
treat
underlying
causes
of
many
genetic
diseases.
CRISPR-based
technologies,
with
their
remarkable
efficiency
easy
programmability,
stand
at
forefront
this
revolution.
In
Review,
we
discuss
current
state
CRISPR
gene
technologies
both
research
therapy,
highlighting
limitations
that
constrain
them
technological
innovations
have
developed
recent
years
address
them.
Additionally,
examine
summarize
landscape
applications
context
health
therapeutics.
Finally,
outline
potential
future
developments
could
shape
coming
years.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(21)
Published: July 21, 2023
Abstract
Chemotherapy
is
widely
recognized
as
an
effective
approach
for
treating
cancer
due
to
its
ability
eliminate
cells
using
chemotherapeutic
drugs.
However,
traditional
chemotherapy
suffers
from
various
drawbacks,
including
limited
solubility
and
stability
of
drugs,
severe
side
effects,
low
bioavailability,
drug
resistance,
challenges
in
tracking
treatment
efficacy.
These
limitations
greatly
hinder
widespread
clinical
application.
In
contrast,
supramolecular
chemotherapy,
which
relies
on
host–guest
interactions,
presents
a
promising
alternative
by
offering
highly
efficient
minimally
toxic
anticancer
delivery.
this
review,
overview
recent
advancements
based
interactions
provided.
The
significant
role
it
plays
guiding
therapy
emphasized.
Drawing
wealth
cutting‐edge
research,
herein,
timely
valuable
resource
individuals
interested
the
field
or
therapy,
presented.
Furthermore,
review
contributes
progression
toward
ACS Central Science,
Journal Year:
2023,
Volume and Issue:
9(7), P. 1269 - 1284
Published: July 14, 2023
Molecular
proximity
orchestrates
biological
function,
and
blocking
existing
proximities
is
an
established
therapeutic
strategy.
By
contrast,
strengthening
or
creating
neoproximity
with
chemistry
enables
modulation
of
processes
high
selectivity
has
the
potential
to
substantially
expand
target
space.
A
plethora
proximity-based
modalities
proteins
via
diverse
approaches
have
recently
emerged,
opening
opportunities
for
biopharmaceutical
innovation.
This
Outlook
outlines
mechanisms
molecules
based
on
induced
proximity,
including
protein
degraders,
blockers,
stabilizers,
inducers
post-translational
modifications,
agents
cell
therapy,
discusses
challenges
that
field
must
address
mature
unlock
translation
in
biology
medicine.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(5), P. 674 - 674
Published: May 16, 2024
The
escalating
demand
for
enhanced
therapeutic
efficacy
and
reduced
adverse
effects
in
the
pharmaceutical
domain
has
catalyzed
a
new
frontier
of
innovation
research
field
pharmacy:
novel
drug
delivery
systems.
These
systems
are
designed
to
address
limitations
conventional
administration,
such
as
abbreviated
half-life,
inadequate
targeting,
low
solubility,
bioavailability.
As
disciplines
pharmacy,
materials
science,
biomedicine
continue
advance
converge,
development
efficient
safe
systems,
including
biopharmaceutical
formulations,
garnered
significant
attention
both
domestically
internationally.
This
article
presents
an
overview
latest
advancements
categorized
into
four
primary
areas:
carrier-based
coupling-based
targeted
intelligent
devices,
based
on
their
main
objectives
methodologies.
Additionally,
it
critically
analyzes
technological
bottlenecks,
current
challenges,
future
trends
application
