Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160369 - 160369
Published: Feb. 1, 2025
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(16)
Published: Jan. 11, 2024
Cancer poses a significant challenge to global public health, seriously threatening human health and life. Although various therapeutic strategies, such as chemotherapy (CT), radiotherapy, phototherapy, starvation therapy, are applied cancer treatment, their limited effect, severe side effects, unsatisfactory drug release behavior need be carefully considered. Thus, there is an urgent develop efficient delivery strategies for improving treatment efficacy realizing on-demand delivery. Notably, pillararenes, emerging class of supramolecular macrocycles, possess unique properties highly tunable structures, superior host-guest chemistry, facile modification, good biocompatibility, which widely used in therapy achieve controllable reduce the toxic effects on normal tissues under internal/external stimuli conditions. This review summarizes recent advance stimuli-responsive systems (SDSs) based pillararenes tumor from perspectives different assembly methods hybrid materials, including molecular-scale SDSs, nano self-assembly systems, nanohybrid SDSs. Moreover, prospects critical challenges SDSs also discussed.
Language: Английский
Citations
57
Chemical Communications, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
This review explores the synthesis, drug loading, and surface modifications of metal–organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy paving way for safer more effective treatments.
Language: Английский
Citations
49
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Feb. 10, 2024
Abstract The combination of macrocyclic chemistry with co-crystal engineering has promoted the development materials vapochromic behaviors in supramolecular science. Herein, we develop a macrocycle based on hybrid[4]arene and 1,2,4,5-tetracyanobenzene that is able to construct materials. After capture benzene toluene vapors, activated hybrid[4]arene-based forms new structures, accompanied by color changes from brown yellow. However, when captures cyclohexane pyridine, neither structures nor colors change. Interestingly, can separate benzene/cyclohexane equal-volume mixture allow be removed toluene/ pyridine purities reaching 100%. In addition, process adsorptive separation visually monitored. selectivity attributed different charge-transfer interaction between vapors. Moreover, reused without losing performance. This work constructs material for hydrocarbon separation.
Language: Английский
Citations
32
Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441
Published: March 22, 2024
Language: Английский
Citations
28
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Oct. 25, 2024
Supramolecular polymers possess great potential in catalysis owing to their distinctive molecular recognition and dynamic crosslinking features. However, investigating supramolecular electrocatalysts with high efficiency oxygen reduction reaction hydrogen peroxide (ORHP) remains an unexplored frontier. Herein, we present organic for ORHP by introducing cyclodextrin-containing noncovalent building blocks, affording these supramolecules abundant bonds. The electronic states kinetics are further well-modulated via a host-guest strategy, resulting appropriate regional electron binding force controllable chemical activity. Notably, integrating units into phenyl group-containing model covalent polymer achieves production rate of 9.14 mol g
Language: Английский
Citations
17
Published: Feb. 1, 2025
Language: Английский
Citations
2
ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16967 - 16981
Published: June 18, 2024
Selective generation of sufficient pyroptosis inducers at the tumor site without external stimulation holds immense significance for a longer duration immunotherapy. Here, we report cascade-amplified inducer CSCCPT/SNAP that utilizes reactive nitrogen species (RNS), self-supplied from diffusion-controlled reaction between oxygen (ROS) and nitric oxide (NO) to potentiate immunotherapy, while both endogenous mitochondrial ROS stimulated by released camptothecin NO initiate pyroptosis. Mechanistically, cascade amplification antitumor immune response is prompted cooperation enhanced RNS with long lifetime, which could be used as trigger effectively compensate inherent drawbacks ROS, resulting in long-lasting favoring Tumor growth efficiently inhibited mouse melanoma tumors through facilitation oxygen/nitrogen (RONS)-NO synergy. In summary, our therapeutic approach supramolecular engineering nanotechnology integrate producers donors tumor-specific stimulus responses into system guarantees synchronous these two elicit pyroptosis-evoked response, using amplifier. RONS-NO synergy achieves sustained robust cancer
Language: Английский
Citations
15
Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(3), P. 1631 - 1638
Published: Jan. 18, 2024
Ortho-chlorotoluene serves as a vital raw material in the petrochemical industries. However, due to alkylation and chlorination, ortho-chlorotoluene is often mixed with meta-chlorotoluene para-chlorotoluene. The selective separation of from chlorotoluene isomers crucial step industrial production. owing close boiling points isomers, traditional methods demand large amount energy. Therefore, there an urgent need develop new achieve efficient isomers. Herein, we developed adsorptive strategy using nonporous adaptive crystals hybrid[3]arene H (Hα). Hα was proved be highly effective binary or ternary mixture Single-crystal structure analysis electrostatic potential maps indicated that selectivity derived stable host–guest between H. Besides, exhibited high recyclability reversible transformation guest-free guest-contained structures.
Language: Английский
Citations
10
Research on Chemical Intermediates, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 11, 2025
Language: Английский
Citations
1
Nano Letters, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Nanomedicines capable of delivering multiple drugs have become essential in combination therapy. However, the challenges low drug loading capacity (DLC) and difficulties administering dosages between different significantly limit antitumor efficacy. In this study, a nanomedicine constructed through rational prodrug nanocarrier design was reported for cancer Initially, phenylborate ester (PBE) group-modified paclitaxel (PTX) (PTX-PBE) synthesized could self-assemble water. Subsequently, combretastatin A4 (CA4) polymer conjugates, mPEG-PCA4 (PCA4), were as nanocarriers to facilitate exceptionally high PTX-PBE precisely controlled manner. Both vitro vivo experiments demonstrated that PCA4 nanoparticles (PCA4/PTX-PBE NPs) exhibited potent efficacy favorable biocompatibility. Our approach provides straightforward, efficient, controllable strategy co-delivery pharmaceuticals clinical
Language: Английский
Citations
1