Critical Assessment of Micellar Surface Charge-Dependent Disaggregation and Reaggregation of a Bis-Indole Self-Aggregate: What Should Be Our Case-Dependent Choice? DOI
Saikat Samanta, Provakar Paul, Arunavo Chatterjee

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(17), P. 8961 - 8970

Published: April 15, 2024

"Aggregation-caused quenching" is a deep-seated mechanism and has been widely used by the researchers as possible basis for new sensor development. Contrast to aggregation, its turn around process, disaggregation, gained much less consideration so far. Unfortunately, study of further scope reaggregation disaggregated probe assembly in same solution, when required, still under rare category. The central theme current focused on this aspect. For purpose, effects headgroup charge (cationic, anionic, nonionic) polarity micelles degree disaggregation subsequent emission amelioration synthesized bis-indole derivative, 3,3′-bisindolyl(phenyl)methane (BIPM), are studied using steady-state time-resolved spectroscopic techniques. relative yield BIPM (φf = 0.01) significantly enhanced presence cetyltrimethylammonium bromide 0.21) polyoxyethylene (20) sorbitan monolaurate 0.24), whereas comparatively enhancement recorded within sodium dodecyl sulfate system 0.07). In contrast, addition an external biophilic agent, uric acid, causes requenching because probes. Detailed microscopic calorimetric studies also adopted investigate disaggregation-reaggregation associations. will provide prior insights about use suitable micellar systems required well modulation efficiency controlled tuning equilibrium similar associations pure aqueous medium avoiding any chemical transformation.

Language: Английский

Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy DOI
Xin Li,

Meili Shen,

Jie Yang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(16)

Published: Jan. 11, 2024

Cancer poses a significant challenge to global public health, seriously threatening human health and life. Although various therapeutic strategies, such as chemotherapy (CT), radiotherapy, phototherapy, starvation therapy, are applied cancer treatment, their limited effect, severe side effects, unsatisfactory drug release behavior need be carefully considered. Thus, there is an urgent develop efficient delivery strategies for improving treatment efficacy realizing on-demand delivery. Notably, pillararenes, emerging class of supramolecular macrocycles, possess unique properties highly tunable structures, superior host-guest chemistry, facile modification, good biocompatibility, which widely used in therapy achieve controllable reduce the toxic effects on normal tissues under internal/external stimuli conditions. This review summarizes recent advance stimuli-responsive systems (SDSs) based pillararenes tumor from perspectives different assembly methods hybrid materials, including molecular-scale SDSs, nano self-assembly systems, nanohybrid SDSs. Moreover, prospects critical challenges SDSs also discussed.

Language: Английский

Citations

62
Immunoadjuvant-Functionalized Metal-Organic Frameworks：Synthesis and Applications in Tumor Immune Modulation DOI
Chen Zhao, Weihua Song,

Jianing Wang

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

This review explores the synthesis, drug loading, and surface modifications of metal–organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy paving way for safer more effective treatments.

Language: Английский

Citations

57
Separation of benzene and toluene associated with vapochromic behaviors by hybrid[4]arene-based co-crystals DOI Creative Commons
Jingyu Chen, Wenjie Zhang, Wenzhi Yang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 10, 2024

Abstract The combination of macrocyclic chemistry with co-crystal engineering has promoted the development materials vapochromic behaviors in supramolecular science. Herein, we develop a macrocycle based on hybrid[4]arene and 1,2,4,5-tetracyanobenzene that is able to construct materials. After capture benzene toluene vapors, activated hybrid[4]arene-based forms new structures, accompanied by color changes from brown yellow. However, when captures cyclohexane pyridine, neither structures nor colors change. Interestingly, can separate benzene/cyclohexane equal-volume mixture allow be removed toluene/ pyridine purities reaching 100%. In addition, process adsorptive separation visually monitored. selectivity attributed different charge-transfer interaction between vapors. Moreover, reused without losing performance. This work constructs material for hydrocarbon separation.

Language: Английский

Citations

33
Supramolecular systems for bioapplications: recent research progress in China DOI
Yue‐Yang Liu, Xiao-Yong Yu, Yu‐Chen Pan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441

Published: March 22, 2024

Language: Английский

Citations

31
Host-guest-induced electronic state triggers two-electron oxygen reduction electrocatalysis DOI Creative Commons

Hongni Chen,

Chao Wang,

Han Wu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 25, 2024

Supramolecular polymers possess great potential in catalysis owing to their distinctive molecular recognition and dynamic crosslinking features. However, investigating supramolecular electrocatalysts with high efficiency oxygen reduction reaction hydrogen peroxide (ORHP) remains an unexplored frontier. Herein, we present organic for ORHP by introducing cyclodextrin-containing noncovalent building blocks, affording these supramolecules abundant bonds. The electronic states kinetics are further well-modulated via a host-guest strategy, resulting appropriate regional electron binding force controllable chemical activity. Notably, integrating units into phenyl group-containing model covalent polymer achieves production rate of 9.14 mol g

Language: Английский

Citations

18
A Cascade-Amplified Pyroptosis Inducer: Optimizing Oxidative Stress Microenvironment by Self-Supplying Reactive Nitrogen Species Enables Potent Cancer Immunotherapy DOI

Binglin Ye,

Wenting Hu,

Guocan Yu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16967 - 16981

Published: June 18, 2024

Selective generation of sufficient pyroptosis inducers at the tumor site without external stimulation holds immense significance for a longer duration immunotherapy. Here, we report cascade-amplified inducer CSCCPT/SNAP that utilizes reactive nitrogen species (RNS), self-supplied from diffusion-controlled reaction between oxygen (ROS) and nitric oxide (NO) to potentiate immunotherapy, while both endogenous mitochondrial ROS stimulated by released camptothecin NO initiate pyroptosis. Mechanistically, cascade amplification antitumor immune response is prompted cooperation enhanced RNS with long lifetime, which could be used as trigger effectively compensate inherent drawbacks ROS, resulting in long-lasting favoring Tumor growth efficiently inhibited mouse melanoma tumors through facilitation oxygen/nitrogen (RONS)-NO synergy. In summary, our therapeutic approach supramolecular engineering nanotechnology integrate producers donors tumor-specific stimulus responses into system guarantees synchronous these two elicit pyroptosis-evoked response, using amplifier. RONS-NO synergy achieves sustained robust cancer

Language: Английский

Citations

16
Selectivity Separation of Ortho-Chlorotoluene Using Nonporous Adaptive Crystals of Hybrid[3]arene DOI
Yuhao Wang,

Sha Wu,

Shiqi Wei

et al.

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(3), P. 1631 - 1638

Published: Jan. 18, 2024

Ortho-chlorotoluene serves as a vital raw material in the petrochemical industries. However, due to alkylation and chlorination, ortho-chlorotoluene is often mixed with meta-chlorotoluene para-chlorotoluene. The selective separation of from chlorotoluene isomers crucial step industrial production. owing close boiling points isomers, traditional methods demand large amount energy. Therefore, there an urgent need develop new achieve efficient isomers. Herein, we developed adsorptive strategy using nonporous adaptive crystals hybrid[3]arene H (Hα). Hα was proved be highly effective binary or ternary mixture Single-crystal structure analysis electrostatic potential maps indicated that selectivity derived stable host–guest between H. Besides, exhibited high recyclability reversible transformation guest-free guest-contained structures.

Language: Английский

Citations

10
Development of a versatile biomaterial of chitosan polymer/ginger (Zingiber officinale Roscoe) extract/ZnO bionanocomposite: physicochemical properties, antioxidant activity, and breast cancer therapy DOI

Muthanna O. Hussein,

Ahmed Saud Abdulhameed

Research on Chemical Intermediates, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

Citations

2
Selenium electrophilic center shuttles active electrons to boost mitochondrial electron leakage DOI Creative Commons
Junping Wang, Mingkai Chen,

Yuanyuan You

et al.

Published: Feb. 1, 2025

Language: Английский

Citations

2
Polymeric Nanoparticles Simultaneously Delivering Paclitaxel Prodrug and Combretastatin A4 with Exceptionally High Drug Loading for Cancer Combination Therapy DOI

Huicong Zhou,

Zhaofan Yang,

Guan-Yu Jin

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Nanomedicines capable of delivering multiple drugs have become essential in combination therapy. However, the challenges low drug loading capacity (DLC) and difficulties administering dosages between different significantly limit antitumor efficacy. In this study, a nanomedicine constructed through rational prodrug nanocarrier design was reported for cancer Initially, phenylborate ester (PBE) group-modified paclitaxel (PTX) (PTX-PBE) synthesized could self-assemble water. Subsequently, combretastatin A4 (CA4) polymer conjugates, mPEG-PCA4 (PCA4), were as nanocarriers to facilitate exceptionally high PTX-PBE precisely controlled manner. Both vitro vivo experiments demonstrated that PCA4 nanoparticles (PCA4/PTX-PBE NPs) exhibited potent efficacy favorable biocompatibility. Our approach provides straightforward, efficient, controllable strategy co-delivery pharmaceuticals clinical

Language: Английский

Citations

1