PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17184 - e17184
Published: March 28, 2024
Single-cell annotation plays a crucial role in the analysis of single-cell genomics data. Despite existence numerous algorithms, comprehensive tool for integrating and comparing these algorithms is also lacking.
Language: Английский
Immunity, Journal Year: 2024, Volume and Issue: 57(2), P. 206 - 222
Published: Feb. 1, 2024
Language: Английский
Citations
64
Nature, Journal Year: 2024, Volume and Issue: 635(8038), P. 453 - 461
Published: Oct. 16, 2024
Microbial systems have been synthetically engineered to deploy therapeutic payloads in vivo1,2. With emerging evidence that bacteria naturally home on tumours3,4 and modulate antitumour immunity5,6, one promising application is the development of bacterial vectors as precision cancer vaccines2,7. Here we probiotic Escherichia coli Nissle 1917 an vaccination platform optimized for enhanced production cytosolic delivery neoepitope-containing peptide arrays, with increased susceptibility blood clearance phagocytosis. These features enhance both safety immunogenicity, achieving a system drives potent specific T cell-mediated anticancer immunity effectively controls or eliminates tumour growth extends survival advanced murine primary metastatic solid tumours. We demonstrate elicited immune response involves recruitment activation dendritic cells, extensive priming neoantigen-specific CD4+ CD8+ broader natural killer reduction tumour-infiltrating immunosuppressive myeloid regulatory B cell populations. Taken together, this work leverages advantages living medicines deliver arrays tumour-specific neoantigen-derived epitopes within optimal context induce specific, effective durable systemic immunity. Probiotic safely
Language: Английский
Citations
35
Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 13, 2025
The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.
Language: Английский
Citations
26
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: Oct. 10, 2024
Pancreatic cancer remains one of the most aggressive solid tumors. As a systemic disease, despite improvement multi-modality treatment strategies, prognosis pancreatic was not improved dramatically. For resectable or borderline patients, surgical strategy centered on improving R0 resection rate is consensus; however, role neoadjuvant therapy in patients and optimal chemotherapy with without radiotherapy were debated. Postoperative adjuvant gemcitabine/capecitabine mFOLFIRINOX recommended regardless margin status. Chemotherapy as first-line for advanced metastatic included FOLFIRINOX, gemcitabine/nab-paclitaxel, NALIRIFOX regimens whereas 5-FU plus liposomal irinotecan only standard care second-line therapy. Immunotherapy an innovative although anti-PD-1 antibody currently agent approved by MSI-H, dMMR, TMB-high tumors, which represent very small subset cancers. Combination strategies to increase immunogenicity overcome immunosuppressive tumor microenvironment may sensitize immunotherapy. Targeted therapies represented PARP KRAS inhibitors are also under investigation, showing benefits progression-free survival objective response rate. This review discusses current modalities highlights cancer.
Language: Английский
Citations
21
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(3), P. 541 - 556.e9
Published: Jan. 16, 2024
Language: Английский
Citations
20
International Journal of Biological Sciences, Journal Year: 2025, Volume and Issue: 21(2), P. 789 - 801
Published: Jan. 1, 2025
As the first T cell immunoglobulin mucin (Tim) family member to be identified, Tim-3 is a powerful immune checkpoint that functions in immunoregulation and induction of tolerance.Conventionally, considered play role adaptive immunity, especially helper cell-mediated responses.As researches progress, has been detected wider range types, modulating function through ligand-receptor interactions other pathways.Strikingly, plays pivotal maternal-fetal tolerance by regulating orchestrating cross-talk.In this review, we elaborate on involvement immunology, with focus its participation provide new insights into during pregnancy.Our work will helpful further understanding pathogenesis pregnancy-related diseases inspire strategies for their diagnosis treatment.
Language: Английский
Citations
3
Journal of the American Society of Nephrology, Journal Year: 2024, Volume and Issue: 35(6), P. 795 - 808
Published: Feb. 14, 2024
Kidney injury molecule-1 (KIM-1), also known as T-cell Ig and mucin domain-1 (TIM-1), is a widely recognized biomarker for AKI, but its biological function less appreciated. KIM-1/TIM-1 belongs to the domain family of conserved transmembrane proteins, which bear characteristic six-cysteine Ig-like variable domain. The latter enables binding natural ligand, phosphatidylserine, expressed on surface apoptotic cells necrotic cells. in variety tissues plays fundamental roles regulating sterile inflammation adaptive immune responses. In kidney, KIM-1 upregulated injured renal proximal tubule cells, transforms them into phagocytes clearance dying helps dampen inflammation. TIM-1, T B killer essential cell activation regulatory functions host. Functional polymorphisms gene KIM-1/TIM-1, HAVCR1 , have been associated with susceptibility immunoinflammatory conditions hepatitis A virus-induced liver failure, thought be due differential ability variants bind phosphatidylserine. This review will summarize role health disease potential clinical applications therapeutic target humans.
Language: Английский
Citations
14
Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 24, 2024
Language: Английский
Citations
13
Cancer Cell, Journal Year: 2024, Volume and Issue: 42(10), P. 1784 - 1797.e4
Published: Oct. 1, 2024
Language: Английский
Citations
11
Journal for ImmunoTherapy of Cancer, Journal Year: 2024, Volume and Issue: 12(4), P. e008636 - e008636
Published: April 1, 2024
Immunotherapy profoundly changed the landscape of cancer therapy by providing long-lasting responses in subsets patients and is now standard care several solid tumor types. However, immunotherapy activity beyond conventional immune checkpoint inhibition plateauing, biomarkers are overall lacking to guide treatment selection. Most studies have focused on T cell engagement response, but there a growing evidence that B cells may be key players establishment an organized notably through tertiary lymphoid structures. Mechanisms response include antibody-dependent cellular cytotoxicity phagocytosis, promotion CD4+ CD8+ activation, maintenance antitumor memory. In types, higher levels cells, specific subpopulations, or presence structures been associated with improved outcomes inhibitors. The fate subpopulations widely influenced cytokine milieu, versatile roles for B-specific cytokines activating factor attracting chemokine-1/CXCL13, master regulatory role IL-10. Roles cell-specific checkpoints such as TIM-1 emerging could represent potential therapeutic targets. Overall, expanding field tumors holds promise improvement current strategies patient
Language: Английский
Citations
10