Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 205, P. 106791 - 106791

Published: Jan. 6, 2025

Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial (ISF), facilitates movement metabolic substances within brain, serving functions akin to those peripheral lymphatic system. This emerging waste clearance mechanism offers a novel perspective on removal pathological in ND. article elucidates recent discoveries regarding system updates relevant concepts model. It discusses potential roles ND, including Alzheimer's disease (AD), Parkinson's (PD), multiple atrophy (MSA), proposes as therapeutic target for these conditions.

Language: Английский

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Glymphatic clearance is enhanced during sleep

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

We here revisited the concept that glymphatic clearance is enhanced by sleep and anesthesia. Utilizing dynamic magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), fluorescent fiber photometry, we report brain both anesthesia, sharply suppressed wakefulness. Another key finding was less tracer enters brains of awake animals across different states can only be compared after adjusting for injected dose.

Language: Английский

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The anatomy of brainwashing

Science, Journal Year: 2024, Volume and Issue: 385(6707), P. 368 - 370

Published: July 25, 2024

Glymphatic-lymphatic brain cleansing may reveal new therapeutic strategies.

Language: Английский

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Assessment of glymphatic function and white matter integrity in children with autism using multi-parametric MRI and machine learning

European Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

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Perivascular brain clearance as a therapeutic target in cerebral amyloid angiopathy and Alzheimer's disease

Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. e00535 - e00535

Published: Jan. 1, 2025

Language: Английский

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Long-wavelength traveling waves of vasomotion modulate the perfusion of cortex

Neuron, Journal Year: 2024, Volume and Issue: 112(14), P. 2349 - 2367.e8

Published: May 22, 2024

Language: Английский

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Synchronized neuronal activity drives waste fluid flow

Nature, Journal Year: 2024, Volume and Issue: 627(8002), P. 44 - 45

Published: Feb. 28, 2024

Language: Английский

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Waste clearance shapes aging brain health

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

SummaryBrain health is intimately connected to fluid flow dynamics that cleanse the brain of potentially harmful waste material. This system regulated by vascular dynamics, maintenance perivascular spaces, neural activity during sleep, and lymphatic drainage in meningeal layers. However, aging can impinge on each these layers regulation, leading impaired cleansing emergence various age-associated neurological disorders, including Alzheimer's Parkinson's diseases. Understanding intricacies regulation how this becomes altered with age could reveal new targets therapeutic strategies tackle decline.

Language: Английский

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Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer’s disease progression

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 12, 2024

Language: Английский

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