Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking DOI Open Access

Claire Cooper,

Daniel Parthier, Jérémie Sibille

et al.

Published: Sept. 20, 2024

Beyond the vast array of functional roles attributed to serotonin (5-HT) in brain, changes 5-HT levels have been shown accompany behavioral states, including WAKE, NREM and REM sleep. Whether dynamics at shorter time scales can be seen delineate substates within these larger brain states remains an open question. Here, we performed simultaneous recordings extracellular using a recently-developed G Protein–Coupled Receptor-Activation–Based sensor (GRAB5-HT3.0) local field potential (LFP) hippocampal CA1, which revealed presence prominent ultraslow (<0.05 Hz) oscillations both during WAKE states. Interestingly, phase was found distinguish across Hippocampal ripples occurred preferentially on falling with higher power concentrating near peak specifically NREM. By contrast, hippocampal-cortical coherence strongest microarousals EMG peaks were most prevalent rising wake Overall, thus potentially temporally segregating internal memory consolidation processes from arousal-related functions.

Language: Английский

Sleep microstructure organizes memory replay DOI Creative Commons
Hongyu Chang, Wenbo Tang,

Annabella M. Wulf

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

4
Offline hippocampal reactivation during dentate spikes supports flexible memory DOI Creative Commons
Stephen B. McHugh, Vítor Lopes‐dos‐Santos, Manfredi Castelli

et al.

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

5
Serotonin modulates infraslow oscillation in the dentate gyrus during Non-REM sleep DOI Open Access
Gergely F. Turi,

Sasa Teng,

Xinyue Chen

et al.

Published: Jan. 22, 2025

Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although considered a sparsely active network wakefulness, 50% granule cells about 25% mossy exhibit increased Further experiments revealed oscillation was correlated rhythmic serotonin release sleep, which oscillates at same but an opposite phase. Genetic manipulation 5-HT receptors neuromodulatory regulation mediated by 5-HT1a knockdown these leads to impairment. Together, our results provide novel mechanistic insights how system can influence patterns

Language: Английский

Citations

0
Synchronous Ensembles of Hippocampal CA1 Pyramidal Neurons Associated with Theta but not Ripple Oscillations During Novel Exploration DOI Open Access

En-Li Chen,

Tsai‐Wen Chen, Eric R. Schreiter

et al.

Published: Feb. 10, 2025

Synchronous neuronal ensembles play a pivotal role in the consolidation of long-term memory hippocampus. However, their organization during acquisition spatial remains less clear. In this study, we used population voltage imaging to investigate synchronization patterns CA1 pyramidal exploration new environment, critical phase for acquisition. We found synchronous comprising approximately 40% neurons, firing simultaneously brief windows (∼25ms) immobility and locomotion novel exploration. Notably, these were not associated with ripple oscillations but instead phase-locked local field potential theta waves. Specifically, subthreshold membrane potentials neurons exhibited coherent depolarizing peak at moment synchrony. Among newly formed place cells, pairs more robust displayed distinct place-specific activities. These findings underscore coordinating cells different fields.

Language: Английский

Citations

0
Serotonin modulates infraslow oscillation in the dentate gyrus during Non-REM sleep DOI Open Access
Gergely F. Turi,

Sasa Teng,

Xinyue Chen

et al.

Published: March 14, 2025

Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although considered a sparsely active network wakefulness, 50% granule cells about 25% mossy exhibit increased sleep, compared to wakefulness. Further experiments revealed oscillation was correlated rhythmic serotonin release which oscillates at same but an opposite phase. Genetic manipulation 5-HT receptors neuromodulatory regulation mediated by 5-HT1a knockdown these leads impairment. Together, our results provide novel mechanistic insights how system can influence patterns

Language: Английский

Citations

0
Synchronous Ensembles of Hippocampal CA1 Pyramidal Neurons Associated with Theta but not Ripple Oscillations During Novel Exploration DOI Open Access

En-Li Chen,

Tsai‐Wen Chen, Eric R. Schreiter

et al.

Published: April 1, 2025

Synchronous neuronal ensembles play a pivotal role in the consolidation of long-term memory hippocampus. However, their organization during acquisition spatial remains less clear. In this study, we used population voltage imaging to investigate synchronization patterns CA1 pyramidal exploration new environment, critical phase for acquisition. We found synchronous comprising approximately 40% neurons, firing simultaneously brief windows (∼25ms) immobility and locomotion novel exploration. Notably, these were not associated with contralateral ripple oscillations but instead phase-locked theta waves recorded region. Moreover, subthreshold membrane potentials neurons exhibited coherent intracellular depolarizing peak at moment synchrony. Among newly formed place cells, pairs more robust displayed distinct place-specific activities. These findings underscore coordinating cells different fields.

Language: Английский

Citations

0
Global coordination of brain activity by the breathing cycle DOI
Adriano B. L. Tort, Diego A. Laplagne, Andreas Draguhn

et al.

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Hippocampal reactivation and replay: Findings and insights from rodent studies DOI
Brian Kim, Kamran Diba

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Serotonin modulates infraslow oscillation in the dentate gyrus during non-REM sleep DOI Creative Commons
Gergely F. Turi,

Sasa Teng,

Xinyue Chen

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: April 3, 2025

Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma, sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles in mice. We found that major glutamatergic cell populations DG infraslow (0.01–0.03 Hz) NREM sleep. Although considered a sparsely active network wakefulness, 50% granule cells about 25% mossy exhibit increased sleep, compared to wakefulness. Further experiments revealed oscillation was correlated rhythmic serotonin release which oscillates at same but an opposite phase. Genetic manipulation 5-HT receptors neuromodulatory regulation mediated by Htr1a knockdown these leads impairment. Together, our results provide novel mechanistic insights how system can influence patterns

Language: Английский

Citations

0
Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking DOI Creative Commons

Claire Cooper,

Daniel Parthier, Jérémie Sibille

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 13, 2024

Abstract Beyond the vast array of functional roles attributed to serotonin (5-HT) in brain, changes 5-HT levels have been shown accompany behavioral states, including WAKE, NREM and REM sleep. Whether dynamics at shorter time scales can be seen delineate substates within these larger brain states remains an open question. Here, we performed simultaneous recordings extracellular using a recently-developed G Protein–Coupled Receptor-Activation–Based sensor (GRAB5-HT3.0) local field potential (LFP) hippocampal CA1, which revealed presence prominent ultraslow (<0.05 Hz) oscillations both during WAKE states. Interestingly, phase was found distinguish across Hippocampal ripples occurred preferentially on falling with higher power concentrating near peak specifically NREM. By contrast, hippocampal-cortical coherence strongest microarousals EMG peaks were most prevalent rising wake Overall, thus potentially temporally segregating internal memory consolidation processes from arousal-related functions.

Language: Английский

Citations

2