DNA damage and its links to neuronal aging and degeneration

Neuron, Journal Year: 2025, Volume and Issue: 113(1), P. 7 - 28

Published: Jan. 1, 2025

Language: Английский

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Self-Improvising Memory: A Perspective on Memories as Agential, Dynamically Reinterpreting Cognitive Glue

Entropy, Journal Year: 2024, Volume and Issue: 26(6), P. 481 - 481

Published: May 31, 2024

Many studies on memory emphasize the material substrate and mechanisms by which data can be stored reliably read out. Here, I focus complementary aspects: need for agents to dynamically reinterpret modify memories suit their ever-changing selves environment. Using examples from developmental biology, evolution, synthetic bioengineering, in addition neuroscience, propose that a perspective as preserving salience, not fidelity, is applicable many phenomena scales cells societies. Continuous commitment creative, adaptive confabulation, molecular behavioral levels, answer persistence paradox it applies individuals whole lineages. also speculate substrate-independent, processual view of life mind suggests memories, patterns excitable medium cognitive systems, could seen active sense-making process. explore diverse set embodied perspectives—nested who interpret each other’s own past messages actions best they (polycomputation). This synthesis unifying symmetries across disciplines, relevance research programs Diverse Intelligence engineering novel minds.

Language: Английский

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The danger theory of immunity revisited

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(12), P. 912 - 928

Published: Nov. 7, 2024

Language: Английский

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Synaptic Plasticity in the Hippocampus

Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 405 - 500

Published: Jan. 1, 2025

Abstract This chapter provides an overview of activity-dependent synaptic plasticity in the hippocampus. It outlines basic properties long-term potentiation (LTP) and depression (LTD) pathways that form core hippocampal trisynaptic circuit, notably Schaffer collateral/commissural (SCC) pathway connecting CA3 to CA1 pyramidal cells. Other significant include projections from medial later entorhinal cortex (EC) distal dendrites principal cells all subfields mossy fiber projection dendate granule The then delves into physiological cell biological mechanisms its contribution hippocampus-dependent memory, including relationship engrams. Another major focus is role dysregulated synaptopathies, with a particular emphasis on neurodevelopmental, psychiatric neurodegenerative brain disorders.

Language: Английский

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The kinase RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during central nervous system viral infection

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Genome editing is poised to revolutionize treatment of genetic diseases, but poor understanding and control DNA repair outcomes hinders its therapeutic potential. especially understudied in nondividing cells like neurons, which must withstand decades damage without replicating. This lack knowledge limits the efficiency precision genome clinically relevant cells. To address this, we used induced pluripotent stem (iPSCs) iPSC-derived neurons examine how postmitotic human Cas9-induced damage. We discovered that can take weeks fully resolve this damage, compared just days isogenic iPSCs. Furthermore, Cas9-treated upregulated unexpected genes, including factors canonically associated with replication. Manipulating response chemical or perturbations allowed us direct neuronal toward desired outcomes. By studying cells, uncovered unforeseen challenges opportunities for precise editing.

Language: Английский

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Memory engram stability and flexibility

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 50(1), P. 285 - 293

Published: Sept. 18, 2024

Language: Английский

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Structural brain preservation: a potential bridge to future medical technologies

Frontiers in Medical Technology, Journal Year: 2024, Volume and Issue: 6

Published: Sept. 9, 2024

When faced with the prospect of death, some people would prefer a form long-term preservation that may allow them to be restored healthy life in future, if technology ever develops point this is feasible and humane. Some believe we have capacity perform type experimental today-although it has never been proven-using contemporary methods preserve structure brain. The idea morphomolecular organization brain encodes information required for psychological properties such as personality memories. If these structures can maintained intact over time, could theoretically provide bridge access restorative technologies future. To consider hypothesis, first describe possible metrics used assess structural quality. We next explore several brain, including traditional cryonics method cryopreservation, well aldehyde-stabilized cryopreservation fluid preservation. focus in-depth on preservation, which relies aldehyde fixation induce chemical gel formation wide set biomolecules appears cost-effective method. two theoretical recovery technologies, alongside ethical legal complexities all will require prudent approach. non-negligible chance allowing successful restoration future deserves serious research efforts by scientific community.

Language: Английский

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Epigenetic Modifications and Neuroplasticity in the Pathogenesis of Depression: A Focus on Early Life Stress

Behavioral Sciences, Journal Year: 2024, Volume and Issue: 14(10), P. 882 - 882

Published: Oct. 1, 2024

Major depressive disorder (MDD) is a debilitating mental illness, and it considered to be one of the leading causes disability globally. The etiology MDD multifactorial, involving an interplay between biological, psychological, social factors. Early life represents critical period for development. Exposure adverse childhood experiences major contributor global burden disease disability, doubling risk developing later in life. Evidence suggests that stressful events experienced during timeframe play role emergence MDD, epigenetic modifications, which might, turn, influence brain structure, function, behavior. Neuroplasticity seems primary pathogenetic mechanism and, similarly mechanisms, particularly sensitive stress early postnatal period. In this review, we will collect discuss recent studies supporting epigenetics neuroplasticity pathogenesis with focus on (ELS). We believe understanding mechanisms by ELS affects offers potential pathways identifying novel therapeutic targets ultimately aiming improve treatment outcomes disorder.

Language: Английский

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NF-κB in Alzheimer’s Disease: Friend or Foe? Opposite Functions in Neurons and Glial Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11353 - 11353

Published: Oct. 22, 2024

Alzheimer's disease (AD) is a devasting neurodegenerative afflicting mainly glutamatergic neurons together with massive neuroinflammation mediated by the transcription factor NF-κB. A 65%-plus increase in patients 2050 might be major threat to society. Hallmarks of AD are neurofibrillary tangles (NFTs) composed hyperphosphorylated tau and amyloid beta (Aβ) plaques. Here, we review potential involvement NF-κB hereditary mutations tumor necrosis pathway patients. One greatest genetic risk factors

Language: Английский

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