Polarizing biotechnologies and a polarized public DOI Creative Commons
Oliver Feeney

Journal of Ethics and Emerging Technologies, Journal Year: 2025, Volume and Issue: 35(2), P. 1 - 9

Published: March 10, 2025

The rapid advancements in genome editing, particularly with CRISPR-Cas9, have brought long-promised medical breakthroughs to reality, but also has accelerated ethically fraught applications. To develop adequate ethical safeguards and effective governance, many endorse public engagement as an essential aspect of this response. This paper tests confidence by applying it emerging existential risk that development when combined similarly rapidly growing socio-political polarisation, poses liberal democracy. While argument some echoes Maxwell Mehlman’s spectre a genetically enhanced "genobility" destroying the basis democracy, I outline how new concern is more plausible, immediate and, moreover, possibly far intractable problem than Mehlman was considering. exacerbated considering perception editing’s potential—rather its actual capabilities—may be affected turn, may worsen rising polarisation. Given positive role respect technology involved here, evaluate effectiveness, arguing certain forms inadvertently things, whereas stronger deliberative approaches hold promise face significant, potentially insurmountable, barriers, at least for now.

Language: Английский

Human embryo editing against disease is unsafe and unproven — despite rosy predictions DOI Creative Commons
Shai Carmi, Henry T. Greely,

Kevin J. Mitchell

et al.

Nature, Journal Year: 2025, Volume and Issue: 637(8046), P. 554 - 556

Published: Jan. 8, 2025

Language: Английский

Citations

1
Should biology put complexity first? DOI
Philip Ball

Cell Systems, Journal Year: 2025, Volume and Issue: unknown, P. 101197 - 101197

Published: Feb. 1, 2025

Language: Английский

Citations

1
The Last Mile in Beta-Cell Replacement Therapy for Type 1 Diabetes: Time to Grow Up DOI Creative Commons
Lorenzo Piemonti

Transplant International, Journal Year: 2025, Volume and Issue: 38

Published: April 1, 2025

Beta cell replacement therapy for type 1 diabetes (T1D) is undergoing a transformative shift, driven by advances in stem biology, gene editing, and tissue engineering. While islet transplantation has demonstrated proof-of-concept success restoring endogenous insulin production, its clinical impact remains limited donor scarcity, immune rejection, procedural complexities. The emergence of cell-derived beta-like cells represents paradigm with initial trials showing promising secretion vivo. However, translating these breakthroughs into scalable, widely accessible treatments poses significant challenges. Drawing parallels to space exploration, this paper argues that while scientific feasibility been demonstrated, true accessibility elusive. Without strategic beta risks becoming an elite intervention, restricted cost infrastructure. Lessons from therapies rare diseases highlight the dangers unsustainable pricing market viability. To bridge "last mile" Quality Design approach proposed, emphasizing scalability, ease use, economic outset. By practical implementation over academic achievements, corporate interests, economics, or patent constraints, can progress viable, treatment.

Language: Английский

Citations

1
Polarizing biotechnologies and a polarized public DOI Creative Commons
Oliver Feeney

Journal of Ethics and Emerging Technologies, Journal Year: 2025, Volume and Issue: 35(2), P. 1 - 9

Published: March 10, 2025

The rapid advancements in genome editing, particularly with CRISPR-Cas9, have brought long-promised medical breakthroughs to reality, but also has accelerated ethically fraught applications. To develop adequate ethical safeguards and effective governance, many endorse public engagement as an essential aspect of this response. This paper tests confidence by applying it emerging existential risk that development when combined similarly rapidly growing socio-political polarisation, poses liberal democracy. While argument some echoes Maxwell Mehlman’s spectre a genetically enhanced "genobility" destroying the basis democracy, I outline how new concern is more plausible, immediate and, moreover, possibly far intractable problem than Mehlman was considering. exacerbated considering perception editing’s potential—rather its actual capabilities—may be affected turn, may worsen rising polarisation. Given positive role respect technology involved here, evaluate effectiveness, arguing certain forms inadvertently things, whereas stronger deliberative approaches hold promise face significant, potentially insurmountable, barriers, at least for now.

Language: Английский

Citations

0