Nature Reviews Drug Discovery, Journal Year: 2023, Volume and Issue: 23(1), P. 67 - 83
Published: Nov. 29, 2023
Language: Английский
Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(11), P. 817 - 838
Published: Aug. 25, 2021
Language: Английский
Citations
1005
Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)
Published: May 21, 2022
Abstract The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range incurable diseases. Recent rapid advances in biotechnology and molecular medicine have enabled the production almost any functional protein/peptide human body by introducing mRNA as vaccine or agent. This represents rising precision field with promise for preventing treating many intractable genetic In addition, vitro transcribed achieved programmed production, which is more effective, faster design well flexible cost-effective than conventional approaches that may offer. Based on these extraordinary advantages, vaccines characteristics swiftest response large-scale outbreaks infectious diseases, such currently devastating pandemic COVID-19. It always been scientists’ desire improve stability, immunogenicity, translation efficiency, delivery system achieve efficient safe mRNA. Excitingly, scientific dreams gradually realized rapid, amazing achievements biology, technology, vaccinology, nanotechnology. this review, we comprehensively describe mRNA-based therapeutics, including their principles, manufacture, application, effects, shortcomings. We also highlight importance optimization systems successful therapeutics discuss key challenges opportunities developing tools into powerful versatile genetic, infectious, cancer, other refractory
Language: Английский
Citations
426
Current Opinion in Immunology, Journal Year: 2020, Volume and Issue: 65, P. 14 - 20
Published: March 31, 2020
Language: Английский
Citations
425
Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 170, P. 83 - 112
Published: Jan. 2, 2021
Language: Английский
Citations
383
ACS Central Science, Journal Year: 2021, Volume and Issue: 7(5), P. 748 - 756
Published: April 6, 2021
The novel coronavirus SARS-CoV-2, the cause of COVID-19 pandemic, has inspired one most efficient vaccine development campaigns in human history. A key aspect mRNA vaccines is use modified nucleobase N1-methylpseudouridine (m1Ψ) to increase their effectiveness. In this Outlook, we summarize and function m1Ψ synthetic mRNAs. By demystifying how a element within these medicines works, aim foster understanding highlight future opportunities for chemical innovation.
Language: Английский
Citations
331
Nature Medicine, Journal Year: 2022, Volume and Issue: 28(11), P. 2273 - 2287
Published: Nov. 1, 2022
Language: Английский
Citations
315
Nature Biotechnology, Journal Year: 2022, Volume and Issue: 40(11), P. 1586 - 1600
Published: Nov. 1, 2022
Language: Английский
Citations
309
Trends in Molecular Medicine, Journal Year: 2019, Volume and Issue: 26(3), P. 311 - 323
Published: Nov. 5, 2019
Language: Английский
Citations
291
Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)
Published: April 15, 2021
Synthetic mRNA provides a template for the synthesis of any given protein, protein fragment or peptide and lends itself to broad range pharmaceutical applications, including different modalities cancer immunotherapy. With ease rapid, large scale Good Manufacturing Practice-grade production, is ideally poised not only off-the shelf vaccines but also personalized neoantigen vaccination. The ability stimulate pattern recognition receptors thus an anti-viral type innate immune response equips mRNA-based with inherent adjuvanticity. Nucleoside modification elimination double-stranded RNA can reduce immunomodulatory activity increase prolong production. In combination nanoparticle-based formulations that transfection efficiency facilitate lymphatic system targeting, nucleoside-modified enables efficient delivery cytokines, costimulatory receptors, therapeutic antibodies. Steady transient production encoded bioactive molecule from improve pharmacokinetic, pharmacodynamic safety properties as compared respective recombinant proteins. This may be harnessed applications benefit higher level expression control, such chimeric antigen receptor (CAR)-modified adoptive T-cell therapies. review highlights advancements in field therapeutics, providing insights into key preclinical developments evolving clinical landscape.
Language: Английский
Citations
285
International Journal of Biological Sciences, Journal Year: 2021, Volume and Issue: 17(6), P. 1446 - 1460
Published: Jan. 1, 2021
The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus -2 (SARS-CoV-2), has impacted human lives in the most profound ways with millions of infections and deaths.Scientists pharmaceutical companies have been race to produce vaccines against SARS-CoV-2.Vaccine generation usually demands years developing testing for efficacy safety.However, it only took less than one year generate two mRNA from their development deployment.The rapid production time, cost-effectiveness, versatility vaccine design, clinically proven ability induce cellular humoral immune response crowned spotlights as promising candidates fight pandemic.In this review, we discuss general principles design working mechanisms vaccines, provide an up-to-date summary pre-clinical clinical trials on seven anti-COVID-19 candidate focus already licensed vaccination.In addition, highlight key strategies designing maximize expression immunogens avoid intrinsic innate response.We also some perspective future COVID-19 other pathogens.
Language: Английский
Citations
275