Advanced near‐infrared light approaches for neuroimaging and neuromodulation

BMEMat, Journal Year: 2023, Volume and Issue: 1(2)

Published: May 5, 2023

Abstract Almost all physiological processes of animals are controlled by the brain, including language, cognitive, memory, learning, emotion and so forth. Minor brain dysfunction usually leads to diseases disorders. Therefore, it' is greatly meaningful urgent for scientists have a better understanding structure function. Optical approaches can provide powerful tools imaging modulating brain. In particular, optical in near‐infrared (NIR) window (700–1700 nm) exhibit excellent prosperities deep tissue penetration low scattering absorption compared with those visible windows (400–700 nm), which provides promising approach develop desired methods neuroimaging neuromodulation tissues. this review, variable types NIR light neural ions, membrane potential, neurotransmitters, other critical molecules functions summarized. latest breakthrough research regulation NIR‐II (1000–1700 highlighted. Finally, we conclude challenges prospects light‐based both basic further clinical translation.

Language: Английский

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A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction

Neuron, Journal Year: 2023, Volume and Issue: 111(19), P. 3053 - 3067.e10

Published: July 21, 2023

Language: Английский

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Retrograde endocannabinoid signaling at inhibitory synapses in vivo

Science, Journal Year: 2024, Volume and Issue: 383(6686), P. 967 - 970

Published: Feb. 29, 2024

Endocannabinoid (eCB)–mediated suppression of inhibitory synapses has been hypothesized, but this not yet demonstrated to occur in vivo because the difficulty tracking eCB dynamics and synaptic plasticity during behavior. In mice navigating a linear track, we observed location-specific signaling hippocampal CA1 place cells, was detected both postsynaptic membrane presynaptic axons. All-optical investigation responses revealed that depolarization followed by potentials. Furthermore, interneuron-specific cannabinoid receptor deletion altered cell tuning. Therefore, rapid, postsynaptic, activity-dependent modulates on timescale seconds

Language: Английский

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The role of serotonin in depression—A historical roundup and future directions

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: March 13, 2024

Abstract Depression is one of the most common psychiatric disorders worldwide, affecting approximately 280 million people, with probably much higher unrecorded cases. associated symptoms such as anhedonia, feelings hopelessness, sleep disturbances, and even suicidal thoughts. Tragically, more than 700 000 people commit suicide each year. Although depression has been studied for many decades, exact mechanisms that lead to are still unknown, available treatments only help a fraction patients. In late 1960s, serotonin hypothesis was published, suggesting key player in depressive disorders. However, this being increasingly doubted there evidence influence other neurotransmitters, noradrenaline, glutamate, dopamine, well larger systemic causes altered activity limbic network or inflammatory processes. narrative review, we aim contribute ongoing debate on involvement depression. We will review evolution antidepressant treatments, research over years, future applications bridge gap between neurotransmitter dynamics using biosensors. These new tools combination applications, provide deeper understanding serotonergic

Language: Английский

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Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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