The Mechanism of Acupuncture Therapy for Migraine: A Systematic Review of Animal Studies on Rats DOI Creative Commons

Yuqiu An,

Jing Zhang,

Qiaosheng Ren

et al.

Journal of Pain Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 473 - 487

Published: Jan. 1, 2025

Acupuncture has long been used for migraine treatment as it is convenient use and remarkable efficacy. The acupuncture-based comprehensive plan widely recognized prevention treatment. However, the mechanism underlying acupuncture efficacy in not yet completely understood. Our goal to systematically analyze evaluate this treatment-related basic research. To retrieve animal experiments investigating action of treatment, We conducted a literature search major databases, period was inception each database April 1, 2024. Literature screened data were extracted independently based on predefined inclusion exclusion criteria. models, points, methods specified included studies statistically analyzed summarized. Furthermore, potential mechanisms discussed. In total, 20 experimental present analysis, all these rats. order frequency use, models employed searched dural stimulation model, nitroglycerin cortical spreading depression model. primary points selected Fengchi (GB20) Yanglingquan (GB34), electroacupuncture most frequently method. primarily involves regulating descending pain modulatory system inhibiting neurotransmitters such CGRP, SP, 5-HT, well microglial cell activation. It also reduces levels inflammatory cytokines, thereby mitigating neurogenic inflammation improving central sensitization. exerts its therapeutic effect by neurotransmitter release, responses, modulating analgesic mechanisms, suppressing glial further in-depth exploration needed study migraine.

Language: Английский

CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond DOI
Andrew F. Russo, Debbie L. Hay

Physiological Reviews, Journal Year: 2022, Volume and Issue: 103(2), P. 1565 - 1644

Published: Dec. 1, 2022

Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory neurons as well other cell types, such motor neuroendocrine cells. CGRP acts via at least G protein-coupled receptors that form unusual complexes receptor activity-modifying proteins. These AMY

Language: Английский

Citations

162
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions DOI
Nilüfer Rahmioğlu, Sally Mortlock,

Marzieh Ghiasi

et al.

Nature Genetics, Journal Year: 2023, Volume and Issue: 55(3), P. 423 - 436

Published: March 1, 2023

Language: Английский

Citations

153
Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine DOI Creative Commons

Lite Yang,

Mengyi Xu, Shamsuddin A. Bhuiyan

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(11), P. 1806 - 1821.e8

Published: March 28, 2022

Language: Английский

Citations

110
Medication overuse headache DOI
Sait Ashina, Gisela M. Terwindt, Timothy J. Steiner

et al.

Nature Reviews Disease Primers, Journal Year: 2023, Volume and Issue: 9(1)

Published: Feb. 2, 2023

Language: Английский

Citations

89
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture DOI Creative Commons
Remi Stevelink, Ciarán Campbell, Siwei Chen

et al.

Nature Genetics, Journal Year: 2023, Volume and Issue: 55(9), P. 1471 - 1482

Published: Aug. 31, 2023

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report multi-ancestry genome-wide association study including 29,944 cases, stratified into three broad categories and seven subtypes epilepsy, 52,538 controls. We identify 26 significant loci, 19 specific genetic generalized epilepsy (GGE). implicate 29 likely causal genes underlying these loci. SNP-based heritability analyses show that common variants explain between 39.6% 90% risk for GGE its subtypes. Subtype analysis revealed markedly different architectures focal epilepsies. Gene-set signals synaptic processes in both excitatory inhibitory neurons the brain. Prioritized candidate overlap with monogenic targets antiseizure medications. Finally, leverage our results alternate drugs predicted efficacy if repurposed treatment.

Language: Английский

Citations

89
Genetics of migraine: where are we now? DOI Creative Commons
Lou Grangeon, Kristin Sophie Lange, Marta Waliszewska‐Prosół

et al.

The Journal of Headache and Pain, Journal Year: 2023, Volume and Issue: 24(1)

Published: Feb. 20, 2023

Abstract Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine with aura associated hereditary small-vessel disorders, identified genes code for proteins expressed in neurons, glial cells, or vessels, all which increase susceptibility to cortical spreading depression. The study migraines has shown that neurovascular unit plays prominent role migraine. Genome-wide association studies have numerous variants each result only small overall risk. more than 180 known belong several networks “pro-migraine” molecular abnormalities, are mainly neuronal vascular. Genetics also highlighted importance shared factors between its major co-morbidities, depression high blood pressure. Further still needed map loci then understand how these genomic lead cell phenotypes.

Language: Английский

Citations

76
Hallmarks of primary headache: part 1 – migraine DOI Creative Commons

Alberto Raggi,

Matilde Leonardi,

Marco A. Arruda

et al.

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 31, 2024

Migraine is a common disabling conditions which, globally, affects 15.2% of the population. It second cause health loss in terms years lived with disability, first among women. Despite being so common, it poorly recognised and too often undertreated. Specialty centres neurologists specific expertise on headache disorders have knowledge to provide care: however, those who do not regularly treat patients migraine will benefit from synopsis most relevant updated information about this condition. This paper presents comprehensive view hallmarks migraine, genetics diagnostic markers, up treatments societal impact, reports elements that identify features.

Language: Английский

Citations

28
Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood DOI
Nikolaos P. Daskalakis, Artemis Iatrou, Chris Chatzinakos

et al.

Science, Journal Year: 2024, Volume and Issue: 384(6698)

Published: May 23, 2024

The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study posttraumatic stress disorder (PTSD) and major depressive (MDD) included the central nucleus amygdala, hippocampal dentate gyrus, medial prefrontal cortex (mPFC). Genes exons within mPFC carried most disease signals replicated across two independent cohorts. Pathways pointed to immune function, neuronal synaptic regulation, hormones. Multiomic factor gene network analyses provided underlying genomic structure. Single RNA sequencing in dorsolateral PFC revealed dysregulated (stress-related) non-neuronal cell types. Analyses brain-blood intersections >50,000 UK Biobank participants were conducted along with fine-mapping results PTSD MDD genome-wide association studies distinguish risk from processes. data suggest shared distinct both propose potential therapeutic targets biomarkers.

Language: Английский

Citations

24
Debate: differences and similarities between tension-type headache and migraine DOI Creative Commons
Dilara Onan, Samaira Younis, William Wells-Gatnik

et al.

The Journal of Headache and Pain, Journal Year: 2023, Volume and Issue: 24(1)

Published: July 20, 2023

Tension-type headache (TTH) and migraine are two common primary headaches distinguished by clinical characteristics according to the 3rd edition of International Classification Headache Disorders. Migraine is identified specific features such as being more prevalent in females, aggravated physical activity, certain genetic factors, having photophobia, phonophobia, nausea, vomiting, or aura, responding drugs. Nonetheless, TTH share some characteristics, onset occurring 20 s, triggered psychological factors like stress, moderate pain severity, mild nausea chronic TTH. Both conditions involve trigeminovascular system their pathophysiology. However, distinguishing between practice, research, epidemiological studies can be challenging, there a lack diagnostic tests biomarkers. Moreover, both may coexist, further complicating process. This review aims explore similarities differences pathophysiology, epidemiology, burden disability, comorbidities, responses pharmacological non-pharmacological treatments migraine. The also discusses future research directions address challenges improve understanding management these conditions.

Language: Английский

Citations

39
Cluster Headache Genomewide Association Study and Meta‐Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor DOI Creative Commons
Bendik S. Winsvold, Aster V. E. Harder, Caroline Ran

et al.

Annals of Neurology, Journal Year: 2023, Volume and Issue: 94(4), P. 713 - 726

Published: July 24, 2023

The objective of this study was to aggregate data for the first genomewide association meta-analysis cluster headache, identify genetic risk variants, and gain biological insights.

Language: Английский

Citations

35