Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(6), P. 428 - 443
Published: March 11, 2024
Language: Английский
Mucosal Immunology, Journal Year: 2021, Volume and Issue: 14(3), P. 555 - 565
Published: Feb. 4, 2021
The gastrointestinal tract is densely innervated by a complex network of neurons that coordinate critical physiological functions. Here, we summarize recent studies investigating the crosstalk between gut-innervating neurons, resident immune cells, and epithelial cells at homeostasis during infection, food allergy, inflammatory bowel disease. We introduce neuroanatomy tract, detailing gut-extrinsic neuron populations from spinal cord brain stem, intrinsic enteric nervous system. highlight roles these play in regulating functions innate adaptive intestinal cells. discuss consequences such signaling for mucosal immunity. Finally, how microbiota integrated into neuro-immune axis tuning neuronal interactions. Understanding molecular events governing axes will enhance our knowledge physiology may provide novel therapeutic targets to treat diseases.
Language: Английский
Citations
217
Immunity, Journal Year: 2020, Volume and Issue: 52(3), P. 464 - 474
Published: March 1, 2020
Language: Английский
Citations
212
Cell Research, Journal Year: 2020, Volume and Issue: 30(6), P. 475 - 491
Published: May 6, 2020
Abstract The multifaceted organization of the immune system involves not only patrolling lymphocytes that constantly monitor antigen-presenting cells in secondary lymphoid organs but also establish permanent tissue-residency. integration respective tissue and adaption to organ milieu enable tissue-resident signaling circuits with parenchymal coordinate responses maintain homeostasis. Innate (ILCs) are innate have a similar functional diversity T including lineage-specifying transcription factors drive certain effector programs. Since their formal discovery 10 years ago, it has become clear ILCs present almost every strongly enriched at barrier surfaces, where they regulate immunity infection, chronic inflammation, maintenance. In this context, recent research identified as key orchestrating homeostasis through ability sustain bidirectional interactions epithelial cells, neurons, stromal adipocytes, many other cells. review, we provide comprehensive discussion studies define development heterogeneity ILC populations impact on adaptive immunity. Further, discuss emerging influence nervous system, circadian rhythm, developmental plasticity function. Uncovering control function will an integrated view how tissues synchronized relevance far beyond classical role discrimination between self/non-self host defense.
Language: Английский
Citations
153
Physiological Reviews, Journal Year: 2022, Volume and Issue: 103(2), P. 1487 - 1564
Published: Dec. 15, 2022
Of all the organ systems in body, gastrointestinal tract is most complicated terms of numbers structures involved, each with different functions, and types signaling molecules utilized. The digestion food absorption nutrients, electrolytes, water occurs a hostile luminal environment that contains large diverse microbiota. At core regulatory control digestive defensive functions enteric nervous system (ENS), complex neurons glia gut wall. In this review, we discuss 1) intrinsic neural involved 2) how ENS interacts immune system, microbiota, epithelium to maintain mucosal defense barrier function. We highlight developments have revolutionized our understanding physiology pathophysiology control. These include new molecular architecture ENS, organization function motor circuits, roles glia. explore transduction stimuli by enteroendocrine cells, regulation intestinal glia, local role microbiota regulating structure ENS. Multifunctional work together glial macrophages, interstitial cells integrating an array signals initiate outputs are precisely regulated space time homeostasis.
Language: Английский
Citations
150
Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(3), P. 157 - 171
Published: Jan. 7, 2022
Language: Английский
Citations
134
Cell, Journal Year: 2022, Volume and Issue: 185(22), P. 4190 - 4205.e25
Published: Oct. 1, 2022
Language: Английский
Citations
130
Science Immunology, Journal Year: 2022, Volume and Issue: 7(72)
Published: June 3, 2022
The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were first to identify responses be under a circadian control. Only last decade, however, have molecular factors governing rhythms been identified. These revealed complex picture of interconnectivity rhythmicity within cells with that their environment. Here, we provide global overview system, focusing on recent advances rapidly expanding field immunology.
Language: Английский
Citations
123
Trends in Molecular Medicine, Journal Year: 2021, Volume and Issue: 27(9), P. 844 - 855
Published: July 3, 2021
Language: Английский
Citations
107
Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(11), P. 749 - 762
Published: June 14, 2023
Language: Английский
Citations
49
Science, Journal Year: 2024, Volume and Issue: 385(6708)
Published: Aug. 1, 2024
Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense. However, the matrix of interactions between arrays molecularly defined neuron subsets immunocyte lineages remains unclear. We used a chemogenetic approach to activate eight distinct neuronal subsets, assessing effects by deep immunophenotyping, microbiome profiling, transcriptomics organs. Distinct immune perturbations followed activation: Nitrergic neurons regulated T helper 17 (T
Language: Английский
Citations
31