Nature Immunology, Journal Year: 2024, Volume and Issue: 25(6), P. 957 - 968
Published: May 29, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: June 26, 2023
Abstract Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties neural regeneration in central nervous system. In past few decades, researchers have attempted to completely elucidate mechanism identify effective strategies promote axon circuit remodeling, but results not been ideal. Recently, new SCI, especially interactions between immune cell responses, revealed by single-cell sequencing spatial transcriptome analysis. With development bioactive materials stem cells, more attention has focused on forming intermediate networks reconstruction than promoting axonal corticospinal tract. Furthermore, technologies control physical parameters such as electricity, magnetism ultrasound constantly innovated applied fate regulation. Among these advanced novel technologies, therapy, biomaterial transplantation, electromagnetic stimulation entered into stage clinical trials, some them already treatment. this review, we outline overall epidemiology pathophysiology expound latest research progress related detail, propose future directions for applications.
Language: Английский
Citations
288
Nature, Journal Year: 2022, Volume and Issue: 607(7919), P. 585 - 592
Published: June 22, 2022
Language: Английский
Citations
210
Genome Medicine, Journal Year: 2023, Volume and Issue: 15(1)
Published: Jan. 26, 2023
Abstract Alzheimer’s disease (AD) is a genetically complex and heterogeneous disorder with multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary tangles, neuroinflammation. Over the past decade, emerging evidence has implicated both beneficial pathological roles for innate immune genes cells, peripheral cells such as T which can infiltrate brain either ameliorate or exacerbate AD neuropathogenesis. These findings support neuroimmune axis of AD, in interplay adaptive systems inside outside critically impacts etiology pathogenesis AD. In this review, we discuss complexities neuropathology at levels genetics cellular physiology, highlighting signaling pathways associated risk interactions among brain. We emphasize role mechanisms by monocytes, influence neuropathology, microglial clearance amyloid-β peptide, key component plaque cores, pro-inflammatory cytotoxic activity microglia, astrogliosis, their vasculature. Finally, review challenges outlook establishing immune-based therapies treating preventing
Language: Английский
Citations
170
Nature Immunology, Journal Year: 2021, Volume and Issue: 22(9), P. 1083 - 1092
Published: Aug. 24, 2021
Language: Английский
Citations
139
Cell and Tissue Research, Journal Year: 2021, Volume and Issue: 387(3), P. 319 - 336
Published: June 2, 2021
Abstract Severe spinal cord injury causes permanent loss of function and sensation throughout the body. The trauma a multifaceted torrent pathophysiological processes which ultimately act to form complex structure, permanently remodeling cellular architecture extracellular matrix. This structure is traditionally termed glial/fibrotic scar. Similar formations occur following stroke, infection, neurodegenerative diseases central nervous system (CNS) signifying their fundamental importance preservation function. It increasingly recognized that scar performs multiple roles affecting recovery traumatic injury. Innovative research into properties this imperative development treatment strategies recover motor CNS trauma. In review, we summarize how regeneration potential alters across phyla age through formation scar-like structures. We describe new insights from next-generation sequencing technologies have yielded more portrait molecular mechanisms governing astrocyte, microglial, neuronal responses development, especially glial component Finally, discuss possible combinatorial therapeutic approaches centering on modulation restore after severe
Language: Английский
Citations
121
Cell, Journal Year: 2023, Volume and Issue: 186(3), P. 607 - 620.e17
Published: Jan. 13, 2023
Language: Английский
Citations
82
Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(5), P. 299 - 312
Published: March 27, 2023
Language: Английский
Citations
59
Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(7), P. 493 - 513
Published: May 24, 2024
Language: Английский
Citations
32
Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)
Published: Jan. 4, 2024
A key pathological factor of Alzheimer's disease (AD), the most prevalent form age-related dementia in world, is excessive β-amyloid protein (Aβ) extracellular aggregation brain. And peripheral blood, a large amount Aβ derived from platelets. So far, causality between levels blood and its brain, particularly role pathology AD, still unclear. relation tau tangles another crucial pathologic contributing to pathogenesis also ambiguous. More recently, anti-Aβ monoclonal antibodies are approved for treatment AD patients through declining mechanism action enhance plasma central nervous system (CNS) clearance, leading decrease burden brain improving cognitive function, which clearly indicates that impacted on involved AD. In addition, innate immune cells remains mostly unknown results obtained were controversial. present review, we summarize recent studies roles Finally, based published data our own work, believe plays an important development progression by impacting cells.
Language: Английский
Citations
22
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(10), P. 2990 - 3003
Published: July 3, 2024
Language: Английский
Citations
16