Systemic immunity in cancer

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(6), P. 345 - 359

Published: April 9, 2021

Language: Английский

---

Targeting cancer metabolism in the era of precision oncology

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 21(2), P. 141 - 162

Published: Dec. 3, 2021

Language: Английский

---

Clinical implications of T cell exhaustion for cancer immunotherapy

Nature Reviews Clinical Oncology, Journal Year: 2022, Volume and Issue: 19(12), P. 775 - 790

Published: Oct. 10, 2022

Language: Английский

---

Mitochondrial dynamics in health and disease: mechanisms and potential targets

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 6, 2023

Abstract Mitochondria are organelles that able to adjust and respond different stressors metabolic needs within a cell, showcasing their plasticity dynamic nature. These abilities allow them effectively coordinate various cellular functions. Mitochondrial dynamics refers the changing process of fission, fusion, mitophagy transport, which is crucial for optimal function in signal transduction metabolism. An imbalance mitochondrial can disrupt function, leading abnormal fate, range diseases, including neurodegenerative disorders, cardiovascular diseases cancers. Herein, we review mechanism dynamics, its impacts on function. We also delve into changes occur during health disease, offer novel perspectives how target modulation dynamics.

Language: Английский

---

CD8+ T cell metabolism in infection and cancer

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(11), P. 718 - 738

Published: May 12, 2021

Language: Английский

---

Hallmarks of T cell aging

Nature Immunology, Journal Year: 2021, Volume and Issue: 22(6), P. 687 - 698

Published: May 13, 2021

Language: Английский

---

Metabolic barriers to cancer immunotherapy

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(12), P. 785 - 797

Published: April 29, 2021

Language: Английский

---

CD8+ T Cell Exhaustion in Cancer

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: July 20, 2021

A paradigm shift in the understanding of exhausted CD8 + T cell (T ex ) lineage is underway. Originally thought to be a uniform population that progressively loses effector function response persistent antigen, single-cell analysis has now revealed composed multiple interconnected subpopulations. The heterogeneity within comprised immune checkpoint blockade (ICB) permissive and refractory subsets termed stem-like terminally differentiated cells, respectively. These populations occupy distinct peripheral intratumoral niches are characterized by transcriptional processes govern transitions between states. This review presents key findings field construct an updated view spatial, transcriptional, functional anti-tumoral . emerging insights broadly call for (re-)focusing cancer immunotherapies center on driver mechanism(s) underlying developmental continuum aimed at stabilizing subsets.

Language: Английский

---

Autophagy in tumour immunity and therapy

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(5), P. 281 - 297

Published: March 23, 2021

Language: Английский

---

Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity

Nature Immunology, Journal Year: 2021, Volume and Issue: 22(6), P. 746 - 756

Published: May 24, 2021

Language: Английский

---