FEBS Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 29, 2024
Within
the
three-dimensional
(3D)
nuclear
space,
genome
organizes
into
a
series
of
orderly
structures
that
impose
important
influences
on
gene
regulation.
T
lymphocytes,
crucial
players
in
adaptive
immune
responses,
undergo
intricate
transcriptional
remodeling
upon
activation,
leading
to
differentiation
specific
effector
and
memory
cell
subsets.
Recent
evidence
suggests
activation
is
accompanied
by
dynamic
changes
architecture
at
multiple
levels,
providing
unique
biological
context
explore
functional
relevance
molecular
mechanisms
3D
organization.
Here,
we
summarize
recent
advances
link
reorganization
programs
conversion
fates
during
differentiation.
We
further
discuss
how
various
chromatin
regulators,
including
CCCTC-binding
factor
several
transcription
factors,
collectively
modulate
this
process.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: June 19, 2023
T
cells
are
crucial
for
immune
functions
to
maintain
health
and
prevent
disease.
cell
development
occurs
in
a
stepwise
process
the
thymus
mainly
generates
CD4
Cell Reports,
Journal Year:
2023,
Volume and Issue:
42(4), P. 112068 - 112068
Published: April 1, 2023
The
spatiotemporal
control
of
gene
expression
is
dependent
on
the
activity
cis-acting
regulatory
sequences,
called
enhancers,
which
regulate
target
genes
over
variable
genomic
distances
and,
often,
by
skipping
intermediate
promoters,
suggesting
mechanisms
that
enhancer-promoter
communication.
Recent
genomics
and
imaging
technologies
have
revealed
highly
complex
interaction
networks,
whereas
advanced
functional
studies
started
interrogating
forces
behind
physical
communication
among
multiple
enhancers
promoters.
In
this
review,
we
first
summarize
our
current
understanding
factors
involved
in
communication,
with
a
particular
focus
recent
papers
new
layers
complexities
to
old
questions.
second
part
subset
connected
"hubs"
discuss
their
potential
functions
signal
integration
regulation,
as
well
putative
might
determine
dynamics
assembly.
The Journal of Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
221(10)
Published: Aug. 21, 2024
The
rate
at
which
cells
enter
the
T
cell
pathway
depends
not
only
on
immigration
of
hematopoietic
precursors
into
strong
Notch
signaling
environment
thymus
but
also
kinetics
with
each
individual
precursor
reaches
T-lineage
commitment
once
it
arrives.
triggers
a
complex,
multistep
gene
regulatory
network
in
steps
are
stereotyped
transition
speeds
between
variable.
Progenitor-associated
transcription
factors
delay
differentiation
even
while
Notch-induced
within
same
push
forward.
Progress
regulator
cross-repression,
breaching
chromatin
barriers,
and
shifting,
competitive
collaborations
stage-specific
stably
expressed
factors,
as
reviewed
here.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: April 1, 2024
Abstract
RORγt
+
group
3
innate
lymphoid
cells
(ILC3s)
are
essential
for
intestinal
homeostasis.
Dysregulation
of
ILC3s
has
been
found
in
the
gut
patients
with
inflammatory
bowel
disease
and
colorectal
cancer,
yet
specific
mechanisms
still
require
more
investigation.
Here
we
observe
increased
β-catenin
from
colon
cancer
compared
healthy
donors.
In
contrast
to
promoting
expression
T
cells,
activation
Wnt/β-catenin
signaling
suppresses
expression,
inhibits
its
proliferation
function,
leads
a
deficiency
subsequent
inflammation
mice.
Activated
interacting
transcription
factor,
TCF-1,
cannot
directly
suppress
but
rather
alters
global
chromatin
accessibility
JunB
which
is
ILC3s.
Together,
our
findings
suggest
that
dysregulated
impairs
through
TCF-1/JunB/RORγt
regulation,
further
disrupting
homeostasis,
cancer.
