Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
30(1)
Published: Sept. 3, 2024
Abstract
N6-methyladenosine
(m
6
A)
modification
stands
out
among
various
RNA
modifications
as
the
predominant
form
within
eukaryotic
cells,
influencing
numerous
cellular
processes
implicated
in
disease
development.
m
A
has
gained
increasing
attention
development
of
atherosclerosis
and
become
a
research
hotspot
recent
years.
Programmed
cell
death
(PCD),
encompassing
apoptosis,
autophagy,
pyroptosis,
ferroptosis,
necroptosis,
plays
pivotal
role
pathogenesis.
In
this
review,
we
delve
into
intricate
interplay
between
diverse
PCD
pathways,
shedding
light
on
their
complex
association
during
onset
progression
atherosclerosis.
Clarifying
relationship
is
great
significance
to
provide
novel
strategies
for
cardiovascular
treatment.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: March 1, 2023
Abstract
N6-methyladenosine
(m
6
A)
methylation
is
the
most
universal
internal
modification
in
eukaryotic
mRNA.
With
elaborate
functions
executed
by
m
A
writers,
erasers,
and
readers,
modulation
involved
myriad
physiological
pathological
processes.
Extensive
studies
have
demonstrated
diverse
tumours,
with
effects
on
tumorigenesis,
metastasis,
resistance.
Recent
evidence
has
revealed
an
emerging
role
of
tumour
immunoregulation,
divergent
patterns
been
microenvironment.
To
depict
regulatory
immune
microenvironment
(TIME)
its
effect
evasion,
this
review
focuses
TIME,
which
characterized
hypoxia,
metabolic
reprogramming,
acidity,
immunosuppression,
outlines
A-regulated
TIME
evasion
under
stimuli.
Furthermore,
anti-tumour
cells
are
summarized.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: June 20, 2024
Abstract
RNA
methylation,
a
prevalent
post-transcriptional
modification,
has
garnered
considerable
attention
in
research
circles.
It
exerts
regulatory
control
over
diverse
biological
functions
by
modulating
splicing,
translation,
transport,
and
stability.
Notably,
studies
have
illuminated
the
substantial
impact
of
methylation
on
tumor
immunity.
The
primary
types
encompass
N6-methyladenosine
(m6A),
5-methylcytosine
(m5C),
N1-methyladenosine
(m1A),
N7-methylguanosine
(m7G),
3-methylcytidine
(m3C).
Compelling
evidence
underscores
involvement
regulating
microenvironment
(TME).
By
affecting
translation
stability
through
"writers",
"erasers"
"readers",
influence
dysregulation
immune
cells
factors.
Consequently,
plays
pivotal
role
immunity
mediating
various
behaviors,
encompassing
proliferation,
invasion,
metastasis,
etc.
In
this
review,
we
discussed
mechanisms
several
methylations,
providing
comprehensive
overview
their
roles
underlying
within
among
immunocytes.
exploring
how
these
modifications
mediate
evasion,
also
examine
potential
applications
immunotherapy.
This
review
aims
to
provide
novel
insights
strategies
for
identifying
targets
advancing
cancer
immunotherapy
efficacy.
Cell Research,
Journal Year:
2023,
Volume and Issue:
33(2), P. 97 - 115
Published: Jan. 5, 2023
Abstract
Autoimmunity
and
autoinflammation
arise
from
aberrant
immunological
inflammatory
responses
toward
self-components,
contributing
to
various
autoimmune
diseases
autoinflammatory
diseases.
RNA-binding
proteins
(RBPs)
are
essential
for
immune
cell
development
function,
mainly
via
exerting
post-transcriptional
regulation
of
RNA
metabolism
function.
Functional
dysregulation
RBPs
abnormities
in
closely
associated
with
multiple
or
disorders.
Distinct
play
critical
roles
autoreactive
orchestrating
a
complex
regulatory
network
consisting
DNAs,
RNAs
within
cells.
In-depth
characterizations
RBP–RNA
interactomes
during
autoimmunity
will
lead
better
understanding
pathogenesis
facilitate
the
effective
therapeutic
strategies.
In
this
review,
we
summarize
discuss
functions
interactions
controlling
inflammation
their
potential
as
biomarkers
targets.
The Innovation,
Journal Year:
2023,
Volume and Issue:
4(4), P. 100452 - 100452
Published: May 29, 2023
•RNA
modification
is
a
novel
hotspot
of
epigenetic
research,
affecting
wide
range
physiological
and
pathological
processes.•RNA
plays
an
important
role
in
tumor
immunity.•RNA
may
be
potential
clinical
therapeutic
target
to
prevent
immune
escape.
An
immunosuppressive
state
typical
feature
the
microenvironment.
Despite
dramatic
success
checkpoint
inhibitor
(ICI)
therapy
preventing
cell
escape
from
surveillance,
primary
acquired
resistance
have
limited
its
use.
Notably,
recent
trials
shown
that
drugs
can
significantly
improve
outcome
ICI
various
cancers,
indicating
importance
modifications
regulation
tumors.
Recently,
RNA
(N6-methyladenosine
[m6A],
N1-methyladenosine
[m1A],
5-methylcytosine
[m5C],
etc.),
areas
been
play
crucial
roles
protumor
antitumor
immunity.
In
this
review,
we
provide
comprehensive
understanding
how
m6A,
m1A,
m5C
function
immunity
by
directly
regulating
different
cells
as
well
indirectly
through
mechanisms,
including
modulating
expression
checkpoints,
inducing
metabolic
reprogramming,
secretion
immune-related
factors.
Finally,
discuss
current
status
strategies
targeting
escape,
highlighting
their
potential.
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Feb. 17, 2025
The
gut
microbiota
undergoes
continuous
variations
among
individuals
and
across
their
lifespan,
shaped
by
diverse
factors
encompassing
diet,
age,
lifestyle
choices,
medication
intake,
disease
states.
These
microbial
inhabitants
play
a
pivotal
role
in
orchestrating
physiological
metabolic
pathways
through
the
production
of
metabolites
like
bile
acids,
choline,
short-chain
fatty
neurotransmitters,
thereby
establishing
dynamic
"gut-organ
axis"
with
host.
intricate
interplay
between
host
is
indispensable
for
health,
RNA
N6-methyladenosine
modification,
epigenetic
mark
on
RNA,
emerges
as
key
player
this
process.
M6A
most
prevalent
internal
modification
eukaryotic
has
garnered
significant
attention
realm
epigenetics.
Recent
findings
underscore
its
potential
to
influence
diversity
intestinal
barrier
function
modulating
gene
expression
patterns.
Conversely,
microbiota,
impact
landscape
cells,
may
indirectly
regulate
recruitment
activity
m6A-modifying
enzymes.
This
review
endeavors
delve
into
biological
functions
m6A
consequences
injury
pathogenesis,
elucidating
partial
possible
mechanisms
which
maintain
health
homeostasis.
Furthermore,
it
also
explores
crosstalk
them
injury,
offering
novel
perspective
that
deepens
our
understanding
underlying
diseases.
Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 507 - 526
Published: Jan. 1, 2024
Systemic
Lupus
Erythematosus
(SLE),
a
prototypical
autoimmune
disorder,
presents
challenge
due
to
the
absence
of
reliable
biomarkers
for
discerning
organ-specific
damage
within
SLE.
A
growing
body
evidence
underscores
pivotal
involvement
N6-methyladenosine
(m6A)
in
etiology
conditions.
The
datasets,
which
primarily
encompassed
expression
profiles
m6A
regulatory
genes,
were
retrieved
from
Gene
Expression
Omnibus
(GEO)
repository.
optimal
model,
selected
either
Random
Forest
(RF)
or
Support
Vector
Machine
(SVM),
was
employed
development
predictive
nomogram
model.
To
identify
genes
associated
with
SLE,
comprehensive
screening
process
conducted
utilizing
LASSO,
SVM-RFE,
and
RF
techniques.
Within
realm
SLE
susceptibility,
Weighted
Co-expression
Network
Analysis
(WGCNA)
harnessed
delineate
relevant
modules
hub
genes.
Additionally,
MeRIP-qPCR
assays
performed
elucidate
key
correlated
targets.
Furthermore,
Mendelian
randomization
study
based
on
genome-wide
association
studies
assess
causative
influence
MMP9
ischemic
stroke
(IS),
is
not
only
severe
cerebrovascular
event
but
also
common
complication
Twelve
identified,
demonstrating
statistical
significance
(p
<
0.05)
utilized
constructing
model
using
algorithm.
EPSTI1,
USP18,
HP,
MMP9,
as
identified.
uniquely
correlates
modification
causally
linked
an
increased
risk
IS,
indicated
by
our
inverse
variance
weighting
analysis
showing
odds
ratio
1.0134
(95%
CI=1.0004-1.0266,
p
=
0.0440).
Our
identified
twelve
regulators,
shedding
light
molecular
mechanisms
underlying
Importantly,
established
causal
relationship
between
m6A-related
gene,
stroke,
thereby
providing
critical
insights
presymptomatic
diagnostic
approaches.
