Hydrogel interfaces for merging humans and machines

Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(12), P. 935 - 952

Published: Oct. 13, 2022

Language: Английский

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Walking naturally after spinal cord injury using a brain–spine interface

Nature, Journal Year: 2023, Volume and Issue: 618(7963), P. 126 - 133

Published: May 24, 2023

A spinal cord injury interrupts the communication between brain and region of that produces walking, leading to paralysis1,2. Here, we restored this with a digital bridge enabled an individual chronic tetraplegia stand walk naturally in community settings. This brain-spine interface (BSI) consists fully implanted recording stimulation systems establish direct link cortical signals3 analogue modulation epidural electrical targeting regions involved production walking4-6. highly reliable BSI is calibrated within few minutes. reliability has remained stable over one year, including during independent use at home. The participant reports enables natural control movements his legs stand, walk, climb stairs even traverse complex terrains. Moreover, neurorehabilitation supported by improved neurological recovery. regained ability crutches overground when was switched off. establishes framework restore movement after paralysis.

Language: Английский

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Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(2), P. 260 - 271

Published: Feb. 1, 2022

Language: Английский

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Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(3), P. 337 - 350

Published: Feb. 28, 2020

Language: Английский

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Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury

Frontiers in Cellular Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: April 3, 2020

Recovery from spinal cord injury (SCI) remains an unsolved problem. As a major component of the SCI lesion, glial scar is primarily composed scar-forming astrocytes and plays crucial role in regeneration. In recent years, it has become increasingly accepted that dual recovery. However, underlying mechanisms this are complex need further clarification. This also makes difficult to manipulate for therapeutic purposes. Here, we briefly discuss formation some representative components associated with astrocytes. Then, analyze dynamic perspective special attention explore role. Finally, taking into account, provide several pieces advice on novel strategies targeting

Language: Английский

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The neurons that restore walking after paralysis

Nature, Journal Year: 2022, Volume and Issue: 611(7936), P. 540 - 547

Published: Nov. 9, 2022

Abstract A spinal cord injury interrupts pathways from the brain and brainstem that project to lumbar cord, leading paralysis. Here we show spatiotemporal epidural electrical stimulation (EES) of 1–3 applied during neurorehabilitation 4,5 (EES REHAB ) restored walking in nine individuals with chronic injury. This recovery involved a reduction neuronal activity humans walking. We hypothesized this unexpected reflects activity-dependent selection specific subpopulations become essential for patient walk after To identify these putative neurons, modelled technological therapeutic features underlying EES mice. single-nucleus RNA sequencing 6–9 spatial transcriptomics 10,11 cords mice chart spatially resolved molecular atlas then employed cell type 12,13 prioritization neurons single population excitatory interneurons nested within intermediate laminae emerged. Although are not required before injury, demonstrate they following Augmenting phenocopied enabled by , whereas ablating them prevented occurs spontaneously moderate thus identified recovery-organizing subpopulation is necessary sufficient regain Moreover, our methodology establishes framework using cartography produce complex behaviours.

Language: Английский

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Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Sept. 9, 2020

The strategies concerning modification of the complex immune pathological inflammatory environment during acute spinal cord injury remain oversimplified and superficial. Inspired by acidic microenvironment at sites, a functional pH-responsive immunoregulation-assisted neural regeneration strategy was constructed. With capability directly responding to focal areas followed triggered release IL-4 plasmid-loaded liposomes within few hours suppress cytokines promote differentiation mesenchymal stem cells in vitro, microenvironment-responsive immunoregulatory electrospun fibers were implanted into rats. Together with sustained nerve growth factor (NGF) achieved microsol core-shell structure, immunological fiber scaffolds revealed bring significantly shifted subtype down-regulate inflammation response, reduce scar tissue formation, angiogenesis as well site, enhance recovery vivo. Overall, this provided delivery system through regulation effect so break current dilemma from contradiction between response regeneration, providing an alternative for treatment injury.

Language: Английский

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Astrocytes in human central nervous system diseases: a frontier for new therapies

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Oct. 13, 2023

Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence the central nervous system (CNS). contribute pathophysiology all neurological neuropsychiatric disorders in ways that can be either beneficial or detrimental disorder outcome. Pathophysiological changes astroglia primary secondary result gain loss functions. respond external, non-cell autonomous signals associated with any form CNS pathology by undergoing complex variable their structure, molecular expression, function. In addition, internally driven, cell astroglial innate properties lead pathologies. Astroglial is complex, different pathophysiological states phenotypes context-specific vary disorder, disorder-stage, comorbidities, age, sex. Here, we classify into (i) reactive astrogliosis, (ii) atrophy function, (iii) degeneration death, (iv) astrocytopathies characterised aberrant forms drive disease. We review across spectrum human diseases disorders, including neurotrauma, stroke, neuroinfection, autoimmune attack epilepsy, as well neurodevelopmental, neurodegenerative, metabolic disorders. Characterising cellular mechanisms represents new frontier identify novel therapeutic strategies.

Language: Английский

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Regulation of axonal regeneration after mammalian spinal cord injury

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(6), P. 396 - 413

Published: Jan. 5, 2023

Language: Английский

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A Tissue‐Like Soft All‐Hydrogel Battery

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(4)

Published: Oct. 29, 2021

To develop wearable and implantable bioelectronics accommodating the dynamic uneven biological tissues reducing undesired immune responses, it is critical to adopt batteries with matched mechanical properties as power sources. However, available cannot reach softness of due high Young's moduli components (e.g., metals, carbon materials, conductive polymers, or composite materials). The fabrication tissue-like soft thus remains a challenge. Here, first ultrasoft totally based on hydrogels are reported. exhibit 80 kPa, perfectly matching skin organs heart). specific capacities 82 mAh g-1 in all-hydrogel lithium-ion 370 zinc-ion at current density 0.5 A achieved. Both stability biocompatibility have been demonstrated upon applications implantable. This work illuminates pathway for designing sources electronics properties.

Language: Английский

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