Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications DOI Open Access
Yuhan Qin, Yong Qiao, Dong Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 141, P. 111872 - 111872

Published: July 7, 2021

Ferroptosis is a type of regulated cell death driven by iron dependent accumulation cellular reactive oxygen species (ROS) when glutathione (GSH)-dependent lipid peroxidation repair systems are compromised. Nuclear receptor co-activator 4 (NCOA4)-mediated selective autophagy ferritin, termed ferritinophagy, involves the regulation ferroptosis. Emerging evidence has revealed that ferritinophagy and ferroptosis exert significant role in occurrence development cardiovascular disease. In present review, we aimed to brief overview focusing on underlying mechanism regulations involved. We summarize discuss relevant research progress diseases accompanied with potential applications modulators treatment ferroptosis-associated diseases.

Language: Английский

Engineering nanomedicine for glutathione depletion-augmented cancer therapy DOI
Yuxuan Xiong, Chen Xiao, Zifu Li

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(10), P. 6013 - 6041

Published: Jan. 1, 2021

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

Language: Английский

Citations

519
Photodynamic Therapy—Current Limitations and Novel Approaches DOI Creative Commons
Gürcan Günaydın, Mustafa Emre Gedik, Seylan Ayan

et al.

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: June 10, 2021

Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via excitation a photosensitizer, so that target tumor cells can be destroyed. PDT applied in settings several malignant diseases. In fact, earliest preclinical applications date back to 1900’s. Dougherty reported treatment skin tumors by 1978. Several further studies around 1980 demonstrated effectiveness PDT. Thus, technique has attracted attention numerous researchers since then. Hematoporphyrin derivative received FDA approval as clinical application 1995. We have indeed witnessed considerable progress field over last century. Given fact favorable adverse event profile and enhance anti-tumor immune responses well demonstrating minimally invasive characteristics, it is disappointing not broadly utilized setting for and/or non-malignant issues still hinder development PDT, such those related with light, tissue oxygenation inherent properties photosensitizers. Various photosensitizers been designed/synthesized order overcome limitations. this Review, we provide general overview mechanisms action terms cancer, including effects system vasculature cell destruction. will also briefly mention The current limitations utilization cancer reviewed, identifying problems associated design/synthesis light might pave way more effective approaches. Furthermore, novel promising approaches improve outcome selectivity, bioengineering, subcellular/organelle targeting, etc. discussed detail, potential pioneering exceptional aim reveal full translation are undoubtedly exciting. A better understanding concepts ( e.g. enhanced, two-stage, fractional PDT) most likely prove very useful pursuing improving strategies.

Language: Английский

Citations

380
Ferroptosis in the tumor microenvironment: perspectives for immunotherapy DOI
Huanji Xu,

Di Ye,

Meiling Ren

et al.

Trends in Molecular Medicine, Journal Year: 2021, Volume and Issue: 27(9), P. 856 - 867

Published: July 23, 2021

Language: Английский

Citations

221
Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy DOI
Hui Li, Yujun Kim,

Hyoje Jung

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(21), P. 8957 - 9008

Published: Jan. 1, 2022

We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.

Language: Английский

Citations

218
The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy DOI Creative Commons
Hai‐Hao Han, Han-Min Wang, Paramesh Jangili

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(3), P. 879 - 920

Published: Jan. 1, 2023

This tutorial review provides a general overview for the design of prodrugs and activatable phototherapeutics which enables development improved therapies.

Language: Английский

Citations

156
The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities DOI Creative Commons

Kamari Weaver,

Rachid Skouta

Biomedicines, Journal Year: 2022, Volume and Issue: 10(4), P. 891 - 891

Published: April 13, 2022

The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators in human body. Its central function involves reduction complex hydroperoxides into their respective alcohols often using reduced Glutathione (GSH) as a reducing agent. GPX4 has become hotspot therapeutic target biomedical research following its characterization chief regulator ferroptosis, and subsequent recognition specific pharmacological for treatment an extensive variety diseases including cancers neurodegenerative disorders. Several recent studies have provided insights how distinguished from rest family, unique biochemical properties GPX4, related to lipid peroxidation enzyme may be modulated potential target. This current report aims review literature underlying all these present up-to-date perspective on understanding

Language: Английский

Citations

127
A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche DOI Creative Commons
Martha A. Zepeda‐Rivera, Samuel S. Minot, Heather Bouzek

et al.

Nature, Journal Year: 2024, Volume and Issue: 628(8007), P. 424 - 432

Published: March 20, 2024

Abstract Fusobacterium nucleatum ( Fn ), a bacterium present in the human oral cavity and rarely found lower gastrointestinal tract of healthy individuals 1 , is enriched colorectal cancer (CRC) tumours 2–5 . High intratumoural loads are associated with recurrence, metastases poorer patient prognosis 5–8 Here, to delineate genetic factors facilitating tumour colonization, we generated closed genomes for 135 strains; 80 strains from without 55 unique cultured 51 patients CRC. Pangenomic analyses identified 483 CRC-enriched factors. Tumour-isolated predominantly belong subspecies animalis Fna ). However, genomic reveal that considered single subspecies, instead composed two distinct clades C1 C2). Of these, only C2 dominates CRC niche. Inter- 195 C2-associated consistent increased metabolic potential colonization tract. In support this, C2-treated mice had an number intestinal adenomas altered metabolites. Microbiome analysis tissue 116 demonstrated enrichment. Comparison 62 paired specimens showed compared normal adjacent tissue. This was further supported by metagenomic stool samples 627 619 individuals. Collectively, our results identify clade bifurcation, show specifically drives reported enrichment underpinnings pathoadaptation

Language: Английский

Citations

126
Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy DOI
Shuang Liang, Jianjun Yao, Dan Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

Citations

124
Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics DOI
Dengshuai Wei, Yong Sun,

Hu Zhu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 23223 - 23261

Published: Dec. 2, 2023

Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen species (ROS), glutathione (GSH), and pH, biological enzymes, external lasers ultrasound, etc., by changing their hydrophobicity/hydrophilicity, degradability, ionizability, thus have been widely used in biomedical applications. Due the characteristics of tumor microenvironment (TME), stimuli-responsive that cater specifically TME extensively prepare smart nanovehicles for targeted delivery therapeutic diagnostic agents tissues. Compared conventional drug nanosystems, TME-responsive nanosystems many advantages, high sensitivity, broad applicability among different tumors, functional versatility, improved biosafety. In recent years, a great deal research has devoted engineering efficient polymeric significant improvement made both cancer diagnosis therapy. this review, we summarize some advances involving use polymer nanocarriers delivery, imaging, therapy, theranostics. Various chemical stimuli will be described context nanosystems. Accordingly, groups responsible responsiveness strategies incorporate these into discussed detail. With on topic expending at fast pace, innovative concepts, sequential cascade release, NIR-II multifunctional formulations, emerged popular enhanced performance, which also included here with up-to-date illustrations. We hope review offer valuable insights selection optimization help accelerate future applications treatment.

Language: Английский

Citations

111
Combined Photodynamic and Photothermal Therapy and Immunotherapy for Cancer Treatment: A Review DOI Creative Commons
Cunqing Kong, Xingcai Chen

International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 6427 - 6446

Published: Dec. 1, 2022

Photoactivation therapy based on photodynamic (PDT) and photothermal (PTT) has been identified as a tumour ablation modality for numerous cancer indications, with photosensitisers conversion agents playing important roles in the phototherapy process, especially recent decades.In addition, iteration of nanotechnology strongly promoted development treatment.PDT can increase sensitivity cells to PTT by interfering microenvironment, whereas heat generated blood flow, improve oxygen supply enhance PDT therapeutic effect.In cell debris serve tumour-associated antigens, evoking antitumor immune responses.In this review, research progress phototherapy, its effects combination immunotherapy treatment tumours are mainly outlined, issues that may need continued attention future raised.

Language: Английский

Citations

93