Light-induced charge generation in polymeric nanoparticles restores vision in advanced-stage retinitis pigmentosa rats DOI Creative Commons
Simona Francia, Dmytro Shmal, Stefano Di Marco

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 27, 2022

Abstract Retinal dystrophies such as Retinitis pigmentosa are among the most prevalent causes of inherited legal blindness, for which treatments in demand. prostheses have been developed to stimulate inner retinal network that, initially spared by degeneration, deteriorates late stages disease. We recently reported that conjugated polymer nanoparticles persistently rescue visual activities after a single subretinal injection Royal College Surgeons rat model . Here we demonstrate can reinstate physiological signals at cortical level and visually driven when microinjected 10-months-old rats bearing fully light-insensitive retinas. The extent restoration positively correlates with nanoparticle density hybrid contacts second-order neurons. results establish functional role organic photovoltaic restoring degenerate retinas intense retina rewiring, stage disease patients subjected prosthetic interventions.

Language: Английский

Frontier applications of retinal nanomedicine: progress, challenges and perspectives DOI Creative Commons

Zhimin Tang,

Fuxiang Ye, Ni Ni

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 25, 2025

The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration permanent vision loss. Effective therapeutic strategies are restricted to treatment or reversal of these conditions. In recent years, nanoscience nanotechnology have revolutionized targeted management retinal diseases. Pharmaceuticals, theranostics, regenerative medicine, gene therapy, prostheses indispensable for interventions been significantly advanced by nanomedical innovations. Hence, this review presents novel insights into use versatile nanomaterial-based nanocomposites frontier applications, including non-invasive drug delivery, theranostic contrast agents, nanoagents, stem cell-based optogenetics prostheses, which mainly reported within last 5 years. Furthermore, progress, potential challenges, future perspectives field highlighted discussed detail, may shed light on clinical translations ultimately, benefit patients with disorders.

Language: Английский

Citations

2
Implantable brain machine interfaces: first-in-human studies, technology challenges and trends DOI Creative Commons
Adrien Rapeaux, Timothy G. Constandinou

Current Opinion in Biotechnology, Journal Year: 2021, Volume and Issue: 72, P. 102 - 111

Published: Nov. 5, 2021

Implantable brain machine interfaces (BMIs) are now on a trajectory to go mainstream, wherein what was once considered last resort will progressively become elective at earlier stages in disease treatment. First-in-human successes have demonstrated the ability decode highly dexterous motor skills such as handwriting, and speech from human cortical activity. These been used for cursor prosthesis control, direct-to-text communication synthesis. Along with these breakthrough studies, technology advancements enabled observation of more channels neural activity through new concepts centralised/distributed implant architectures. This is complemented by research flexible substrates, packaging, surgical workflows data processing. New regulatory guidance funding has galvanised field. culmination resource, efforts capability attracting significant investment BMI commercialisation. paper reviews recent developments describes paradigm shift development that leading innovations, insights translation.

Language: Английский

Citations

81
Bioengineering strategies for restoring vision DOI
Jasmina Cehajic‐Kapetanovic, Mandeep S. Singh, Eberhart Zrenner

et al.

Nature Biomedical Engineering, Journal Year: 2022, Volume and Issue: 7(4), P. 387 - 404

Published: Jan. 31, 2022

Language: Английский

Citations

57
Optogenetics for transcriptional programming and genetic engineering DOI

Tien‐Hung Lan,

Lian He, Yun Huang

et al.

Trends in Genetics, Journal Year: 2022, Volume and Issue: 38(12), P. 1253 - 1270

Published: June 20, 2022

Language: Английский

Citations

48
Light-induced charge generation in polymeric nanoparticles restores vision in advanced-stage retinitis pigmentosa rats DOI Creative Commons
Simona Francia, Dmytro Shmal, Stefano Di Marco

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 27, 2022

Abstract Retinal dystrophies such as Retinitis pigmentosa are among the most prevalent causes of inherited legal blindness, for which treatments in demand. prostheses have been developed to stimulate inner retinal network that, initially spared by degeneration, deteriorates late stages disease. We recently reported that conjugated polymer nanoparticles persistently rescue visual activities after a single subretinal injection Royal College Surgeons rat model . Here we demonstrate can reinstate physiological signals at cortical level and visually driven when microinjected 10-months-old rats bearing fully light-insensitive retinas. The extent restoration positively correlates with nanoparticle density hybrid contacts second-order neurons. results establish functional role organic photovoltaic restoring degenerate retinas intense retina rewiring, stage disease patients subjected prosthetic interventions.

Language: Английский

Citations

48