Materials Horizons, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Photo- and electro-active poly(3-hexylthiophene) (P3HT)-based materials serve as efficient highly biocompatible phototransducers for cutting-edge bioelectronic applications.
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114770 - 114770
Published: March 7, 2023
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains huge challenge due multiple barriers that significantly the ultimate therapeutic efficacy drugs. Recent advances in nanocarrier technology offer promising opportunity overcome these by providing enhanced penetration, increased retention, improved solubility, reduced toxicity, prolonged release, targeted loaded eyes. This review primarily provides an overview progress contemporary applications nanocarriers, mainly polymer- lipid-based treating various eye highlighting their value achieving delivery. Additionally, covers administration routes, as well prospective future developments challenges field nanocarriers for diseases.
Language: Английский
Citations
151
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 25, 2025
The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration permanent vision loss. Effective therapeutic strategies are restricted to treatment or reversal of these conditions. In recent years, nanoscience nanotechnology have revolutionized targeted management retinal diseases. Pharmaceuticals, theranostics, regenerative medicine, gene therapy, prostheses indispensable for interventions been significantly advanced by nanomedical innovations. Hence, this review presents novel insights into use versatile nanomaterial-based nanocomposites frontier applications, including non-invasive drug delivery, theranostic contrast agents, nanoagents, stem cell-based optogenetics prostheses, which mainly reported within last 5 years. Furthermore, progress, potential challenges, future perspectives field highlighted discussed detail, may shed light on clinical translations ultimately, benefit patients with disorders.
Language: Английский
Citations
2
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Sept. 7, 2023
Abstract Conjugated polymer films, which can conduct both ionic and electronic charges, are central to building soft sensors actuators. Despite the possible interplay between light absorption mixed conductivity of these materials in aqueous biological media, no single film has been utilized create a solar-switchable organic bioelectronic circuit that relies on fully reversible redox reaction-free potentiometric photodetection current modulation. Here we demonstrate by an electron cation-transporting reversibly modulates its electrochemical potential electrolyte, is harnessed design n-type photo-electrochemical transistor (n-OPECT). By controlling intensity incident polymeric gate electrode, generate output characteristics mimic modulation channel achieved through voltage control. The micron-scale n-OPECT exhibits high signal-to-noise ratio excellent sensitivity low intensities. We three direct applications n-OPECT, i.e., photoplethysmogram recorder, light-controlled inverter circuit, light-gated artificial synapse, underscoring suitability this platform for myriad biomedical involve changes.
Language: Английский
Citations
40
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(3), P. 474 - 474
Published: March 22, 2023
Sufficient ocular bioavailability is often considered a challenge by the researchers, due to complex structure of eye and its protective physiological mechanisms. In addition, low viscosity drops resulting short residence time further contribute observed drug concentration at target site. Therefore, various delivery platforms are being developed enhance bioavailability, provide controlled sustained release, reduce number applications, maximize therapy outcomes. Solid lipid nanoparticles (SLNs) nanostructured carriers (NLCs) exhibit all these benefits, in addition biocompatible, biodegradable, susceptible sterilization scale-up. Furthermore, their successive surface modification contributes prolonged (by adding cationic compounds), enhanced penetration, improved performance. The review highlights salient characteristics SLNs NLCs concerning delivery, updates research progress this area.
Language: Английский
Citations
29
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)
Published: Feb. 21, 2024
Medical microrobotics is an emerging field to revolutionize clinical applications in diagnostics and therapeutics of various diseases. On the other hand, mobile has important obstacles pass before translation. This article focuses on these challenges provides a roadmap medical microrobots enable their use. From concept "magic bullet" physicochemical interactions complex biological environments applications, there are several translational steps consider. Clinical translation only possible with close collaboration between experts researchers address technical microfabrication, safety, imaging. The application potential can be materialized by designing that solve current main challenges, such as actuation limitations, material stability, imaging constraints. strengths weaknesses progress discussed for near future outlined.
Language: Английский
Citations
14
Nano Today, Journal Year: 2024, Volume and Issue: 54, P. 102117 - 102117
Published: Jan. 4, 2024
Language: Английский
Citations
7
Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(9), P. 1398 - 1410
Published: April 23, 2024
ConspectusElectrical neuromodulation has achieved significant translational advancements, including the development of deep brain stimulators for managing neural disorders and vagus nerve seizure treatment. Optoelectronics, in contrast to wired electrical systems, offers leadless feature that guides multisite high spatiotemporal system targeting, ensuring specificity precision therapies known as "photoelectroceuticals". This Account provides a concise overview developments novel optoelectronic nanomaterials are engineered through innovative molecular, chemical, nanostructure designs facilitate interfacing with efficiency minimally invasive implantation.This outlines progress made both within our laboratory across broader scientific community, particular attention implications materials innovation strategies, studying bioelectrical activation methods, applications regenerative medicine. In innovation, we highlight nongenetic, biocompatible, approach spans various length scales, from single neurons tissues using nanosized particles monolithic membranes. Furthermore, discussion exposes critical unresolved questions field, mechanisms interaction at nanobio interface, cellular or tissue integration into existing networks modulation. addition, present challenges pressing needs long-term stability biocompatibility, scalability clinical applications, noninvasive monitoring control systems.In addressing field interfaces, particularly envisage promising strategic directions could significantly advance this burgeoning domain. involves deeper theoretical understanding nanobiointerfaces, where simulations experimental validations on how interact spatiotemporally biological systems crucial. The more durable is vital prolonged dynamic ability manipulate activity spatial resolution, paves way targeting individual specific circuits. Additionally, integrating these interfaces advanced possibly leveraging artificial intelligence machine learning algorithms programming dynamically responsive designs, ease implementation stimulation recording. These innovations hold potential introduce treatment modalities wide range neurological systemic disorders.
Language: Английский
Citations
7
Science Advances, Journal Year: 2024, Volume and Issue: 10(35)
Published: Aug. 28, 2024
The mammalian retina is considered an autonomous circuit, yet work dating back to Ramon y Cajal indicates that it receives inputs from the brain. How such affect retinal processing has remained unknown. We confirmed brain-to-retina projections of histaminergic neurons mouse hypothalamus. Histamine application ex vivo altered activity various ganglion cells (RGCs), including direction-selective RGCs gained responses high motion velocities. These results were reproduced in with optic tract recordings where retinopetal axons activated chemogenetically. Such changes could improve vision fast-moving objects (e.g., while running), which fits known increased during arousal. An antihistamine drug reduced optomotor high-speed moving stimuli freely mice. In humans, same nonuniformly modulated visual sensitivity across field, indicating evolutionary conserved function system. Our findings expose a previously unappreciated role for modulating function.
Language: Английский
Citations
7
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2070 - 2085
Published: March 15, 2024
Retinal diseases, such as age-related macular degeneration, diabetic retinopathy, and retinoblastoma, stand the leading causes of irreversible vision impairment blindness worldwide. Effectively administering drugs for retinal diseases poses a formidable challenge due to presence complex ocular barriers elimination mechanisms. Over time, various approaches have been developed fabricate drug delivery systems improving therapy including virus vectors, lipid nanoparticles, polymers. However, conventional nanocarriers encounter issues related controllability, efficiency, safety in retina. Therefore, development smart effective or more invasive long-term treatment remains desirable goal. Recently, surfaced intelligent design nanocarriers, leveraging specific responses external internal triggers enabling multiple functions topical administration, prolonged release, site-specific delivery. This Review provides an overview prevalent pathologies pharmacotherapies enhance understanding diseases. It also surveys recent developments strategies employed disease. Finally, challenges potential clinical therapeutic applications are discussed inspire next generation nanocarriers.
Language: Английский
Citations
6
ACS Nano, Journal Year: 2022, Volume and Issue: 16(12), P. 19892 - 19912
Published: Nov. 21, 2022
Nanomaterials at the neural interface can provide bridge between bioelectronic devices and native tissues achieve bidirectional transmission of signals with our brain. Photoactive nanomaterials, such as inorganic polymeric nanoparticles, nanotubes, nanowires, nanorods, nanosheets or related, are being explored to mimic, modulate, control, even substitute functions cells tissues. They show great promise in next generation technologies for excellent spatial temporal accuracy. In this review, we highlight discovery understanding these nanomaterials precise control an individual neuron, biomimetic retinal prosthetics vision restoration, repair regeneration central peripheral tissues, wireless deep brain stimulation treatment movement mental disorders. The most intriguing feature is that photoactive materials fit within a minimally invasive strategy trigger flux neurologically active molecules thus influences cell membrane potential key signaling molecule related gene expression. particular, focus on worthy pathways photosignal transduction nanomaterial–neural behavior biological system. Finally, describe challenges how design specific neurological There also some open issues long-term stability signal efficiency further explore clinical practice.
Language: Английский
Citations
23