The potential importance of the built-environment microbiome and its impact on human health

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(20)

Published: April 25, 2024

There is increasing evidence that interactions between microbes and their hosts not only play a role in determining health disease but also emotions, thought, behavior. Built environments greatly influence microbiome exposures because of built-in highly specific microbiomes coproduced with myriad metaorganisms including humans, pets, plants, rodents, insects. Seemingly static built structures host complex ecologies microorganisms are starting to be mapped. These microbial directly interdependently affected by social, spatial, technological norms. Advances technology have made these organisms visible forced the scientific community architects rethink gene–environment microbe respectively. Thus, environment design must consider microbiome, research involving host–microbiome interaction built-environment. This paradigm shift becomes increasingly important as grows contemporary steadily reducing diversity essential for human health, well-being, resilience while accelerating symptoms chronic diseases environmental allergies, other more life-altering diseases. New models required balance maximizing exposure minimizing human-associated Sustained trans-disciplinary across time (evolutionary, historical, generational) space (cultural geographical) needed develop experimental protocols address multigenerational multispecies equity environments.

Language: Английский

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Macronutrient balance determines the human gut microbiome eubiosis: insights from in vitro gastrointestinal digestion and fermentation of eight pulse species

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 30, 2025

The interactions between macronutrients, the human gut microbiome, and their metabolites (short-chain fatty acids) were comprehensively investigated via an in vitro digestion fermentation model subjected to eight pulse species. 16S rRNA sequencing taxonomic analysis of digesta fermented for up 24 h revealed increase relative abundance health-detrimental genera represented by Escherichia-Shigella kidney bean, soybean, cowpea, chickpea, black bean samples. In contrast, health-positive genera, including Bacteroides , Eubacterium Akkermansia was elevated red mung Heunguseul. At same time, proportion pathogenic decreased. Concurrently, these three species exhibited microbial diversity as evidenced calculation α -diversity (Shannon index) β (Bray-Curtis distance). Despite lower nutrient contents pulses, carbohydrates, amino acids, network that possess complex positive or negative correlations with a variety bacteria, well metabolites. These more pronounced Heunguseul than other pulses. It postulated overall potential nourish environments due balance nutritional components. linear regression demonstrated there association carbohydrate acid Shannon indices. Furthermore, ratio carbohydrates acids displayed increase. showed weak correlation. is noteworthy diet comprising foods balanced profile supports growth beneficial microbes, thereby promoting eubiosis. Consistent work on different ingredients essential precise insight into interplay food microbiome dietary patterns.

Language: Английский

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Multifluid Metabolomics Identifies Novel Biomarkers for Irritable Bowel Syndrome

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 121 - 121

Published: Feb. 12, 2025

Background/Objectives: Irritable bowel syndrome (IBS) is a complex disorder affecting 10% of the global population, but underlying mechanisms remain poorly understood. By integrating multifluid metabolomics, we aimed to identify metabolite markers IBS in large population-based cohort. Methods: We included individuals from TwinsUK with and without IBS, ascertained using Rome III criteria, analysed serum (232 cases, 1707 controls), urine (185 1341 stool (186 1284 controls) metabolites (Metabolon Inc.). Results: After adjusting for covariates, multiple testing, 44 unique (25 novel) were associated including lipids, amino acids, xenobiotics. Androsterone sulphate, sulfated steroid hormone precursor, was lower odds both (0.69 [95% confidence interval = 0.56-0.85], p 2.34 × 10-4) (0.75 [0.63-0.90], 1.54 10-3. Moreover, suberate (C8-DC) higher (1.36 [1.15-1.61]; 1.84 (0.76 [0.63-0.91]; 2.30 10-3). On contrary, 32 appeared be fluid-specific, indole, 13-HODE + 9-HODE, pterin, bilirubin (E,Z or Z,Z), urolithin. The remaining 10 one fluid suggestive evidence (p < 0.05) another fluid. Finally, identified androgenic signalling, dicarboxylates, haemoglobin, porphyrin metabolism significantly over-represented compared controls. Conclusions: Our results highlight utility multi-fluid approach research, revealing distinct metabolic signatures across biofluids.

Language: Английский

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Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 11971 - 11971

Published: July 26, 2023

A great deal of evidence has revealed an important link between gut microbiota and the heart. In particular, plays a key role in onset cardiovascular (CV) disease, including heart failure (HF). HF, splanchnic hypoperfusion causes intestinal ischemia resulting translocation bacteria their metabolites into blood circulation. Among these metabolites, most is Trimethylamine N-Oxide (TMAO), which responsible, through various mechanisms, for pathological processes different organs tissues. this review, we summarise complex interaction CV particularly with respect to possible strategies influencing its composition function. Finally, highlight potential TMAO as novel prognostic marker new therapeutic target HF.

Language: Английский

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MetaPhlAn 4 profiling of unknown species-level genome bins improves the characterization of diet-associated microbiome changes in mice

Cell Reports, Journal Year: 2023, Volume and Issue: 42(5), P. 112464 - 112464

Published: May 1, 2023

Mouse models are key tools for investigating host-microbiome interactions. However, shotgun metagenomics can only profile a limited fraction of the mouse gut microbiome. Here, we employ metagenomic profiling method, MetaPhlAn 4, which exploits large catalog metagenome-assembled genomes (including 22,718 from mice) to improve We combine 622 samples eight public datasets and an additional cohort 97 microbiomes, assess potential 4 better identify diet-related changes in host microbiome using meta-analysis approach. find multiple, strong, reproducible microbial biomarkers, largely increasing those identifiable by other available methods relying on reference information. The strongest drivers diet-induced uncharacterized previously undetected taxa, confirming importance adopting integrating assemblies comprehensive profiling.

Language: Английский

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Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health

Cell Reports, Journal Year: 2024, Volume and Issue: 43(2), P. 113728 - 113728

Published: Jan. 31, 2024

Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, bacterial communities their activities can be altered by bacteriophages (also known simply as phages), bacteria-infecting viruses, making these biological entities key regulators human cardiometabolic health. The manipulation populations phages enables possibility using treatment through phage therapy fecal viral transplants. First, however, a deeper understanding role phageome is required. In this review, we first introduce component microbiome discuss transplants relation to diseases. We then summarize current state research propose how might indirectly influence health bacteria metabolites.

Language: Английский

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iMetaOmics: Advancing human and environmental health through integrated meta‐omics

iMetaOmics., Journal Year: 2024, Volume and Issue: 1(1)

Published: Aug. 8, 2024

iMetaOmics is a quarterly international journal with the priority of publishing research work within scope One Health, featured well-designed omics. The also welcomes systematic integration extensive public datasets, new and meaningful perspectives, re-analysis high-impact data yielding different/valuable conclusions. microbiome plays critical roles in human [1], animal [2], plant nutrition health [3], food [4], environment [5], as well other aspects society (Figure 1). Metaomics, including metabarcoding, metagenomics, metatranscriptomics, metaproteomics, metabolomics, provide unique powerful tools to better understand taxonomy functions microbiome, biology, [6]. Aiming fill gap lacking top journals field Asia, iMeta Science Society its thousands Chinese scientist members found young but journal—iMeta (ISSN: 2770-5986; eISSN: 2770-596X). It has published more than 200 high-quality papers since 2022, original articles, reproducible methods protocols, systemic reviews peers updated novel findings, easy-to-use analytic tools, knowledge [7]. These publications include are not limited gut pertaining diseases [8], microbiota animals (e.g., chicken [9], pig [10], panda [11]), pan-cancer [12] pan-genome [13], soil associated diversity defense [14, 15], popular for metaomics analyses [16-18]. With great efforts contributions our stakeholders, like publisher, editorial board members, authors, reviewers, received first impact factor 23.7 2024, gradually accumulating broad diverse audiences readership, especially attracting explosive growth submissions recent days. To cope significantly increased submissions, we have from bimonthly journal. However, publication space maintaining high standard iMeta, still reject 90% although many them did an excellent work. Due success officially launching sister (eISSN: 2996-9514, ISSN: 2996-9506), further publish articles [19-23], [24-28], state-of-the-art methodologies [29, 30] satisfy increasing submission demand iMeta. Taking advantage same team, rejected manuscripts valuable/meaningful findings will be transferred iMetaOmics, together detailed comments reviewers. In this context, following review process shortened promote rapid publishing. Before official launch, 12 already been upon approval by authors issue. Currently, featuring reanalysis expected that establish reputation soon, attract wide range interest readers, contribute progress Human Environmental Health studies. Authors' own priority, while utilization analysis robust experimental validation can considered. Multiple evidence required support conclusion. New strategies advantage, indispensable. All used without reasonable concerns should publicly/temporally accessible reviewers editors. A video tutorial, software download, installation, operation, result displaying, highly recommended bioinformatic tools. Additionally, necessary ethics numbers, clear layouts, figures, significant expected. Chun-Lin Shi: Writing—original draft; writing—review editing. Tong Chen: Writing—review Canhui Lan: Ren-You Gan: Jun Yu: Fangqing Zhao: Yong-Xin Liu: editing; conceptualization. Zhao Yu hold position Editor-in-Chief iMetaOmics. Liu, Chen, Lan, Shi Gan Executive Editors

Language: Английский

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Food pairing independently associated with cardiometabolic traits beyond dietary patterns across western and eastern populations

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Cardiometabolic health is closely linked to diet. Both specific food choices and dietary indices are commonly used guide cardiometabolic protection strategies. However, the balance between foods may also significantly impact health. Here, we explore imbalance in long-term intake quantify pairing patterns (FPs), providing insights beyond conventional single-food frequencies. Using data from our GGMP (n = 6,994) NHANES 7,350) cohorts, observed that independent of single frequency indices. We identified 1,759 306 cardiometabolic-related two cohorts (FDR < 0.05), respectively. Notably, around 80% these not individually associated with traits, pattern associations traits at hyper group level were consistent across Eastern Western populations. Besides, mediation analysis revealed 72.7% affected through 31 microbial genera, Clostridiumsensustricto1 playing a predominant role. Moreover, multi-step found microbes mediated on primarily their metabolic pathways, such as pyruvate fermentation propanoate ergothioneine biosynthesis pathways. Our suggest broadly by modulating gut functionalities, contrast lower occurrence when considering individual isolation. These results offer novel perspective for designing personalized strategies present enhance

Language: Английский

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Moderate full-fat and low-fat yoghurt consumption correlates with reduced mortality risk: a large-scale prospective analysis

Journal of Global Health, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 16, 2025

Yoghurt is a commonly consumed fermented food recommended by many guidelines. consumption can contribute to the intake of multiple nutrients and reduce risk several diseases. However, prospective evidence limited on associations between full/low-fat yoghurt mortality risk. In this cohort study, we aimed assess dose-dependent all-cause or cause-specific mortality. We enrolled 186 168 participants from UK Biobank who had joined study 2006 2010 were followed up until 2022. obtained data self-reported all causes specific death, including cancers cardiovascular diseases (CVDs). then used Cox proportional hazard models calculate ratio (HR) 95% confidence interval (CI) evaluate full-fat low-fat Lastly, conducted subgroup sensitivity analyses examine robustness our findings. A total 9402 deaths occurred during mean follow-up 13.4 years, 1687 CVD-related 5073 cancer-related deaths. Relative non-consumers, HRs (95% CIs) for in consuming >0-50, 50-100, >100 g day 0.82 CI = 0.72, 0.93), 0.97 0.86, 1.09), 0.96 0.84, 1.1) respectively. The corresponding HR estimates relative non-consumers 0.88 0.81, 0.95), 0.91 0.85, 0.98), 0.95 0.89, 1.01), Subgroup analysis indicated women moderate lower risk, while men Moderate was correlated with decreased Future studies are warranted verify potential adopting as part healthy diet

Language: Английский

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Establishing baselines for prebiotic production in controlled environments for applications in space and vertical farming

Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e42112 - e42112

Published: Jan. 1, 2025

Language: Английский

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