Nature Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Abstract
Previous
studies
have
suggested
that
systemic
viral
infections
may
increase
risks
of
dementia.
Whether
this
holds
true
for
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
virus
is
unknown.
Determining
important
anticipating
the
potential
future
incidence
To
begin
to
do
this,
we
measured
plasma
biomarkers
linked
Alzheimer’s
disease
pathology
in
UK
Biobank
before
and
after
serology-confirmed
SARS-CoV-2
infections.
infection
was
associated
with
β-amyloid
pathology:
reduced
Aβ42:Aβ40
ratio
and,
more
vulnerable
participants,
lower
Aβ42
higher
pTau-181.
The
biomarker
changes
were
greater
participants
who
had
been
hospitalized
COVID-19
or
reported
hypertension
previously.
We
showed
brain
structural
imaging
patterns
disease,
cognitive
test
scores
poorer
overall
health
evaluations.
Our
data
from
post
hoc
case–control
matched
study
thus
provide
observational
evidence
can
be
older
adults.
While
these
results
not
establish
causality,
they
suggest
(and
possibly
other
inflammatory
diseases)
risk
disease.
Aging Cell,
Journal Year:
2024,
Volume and Issue:
23(8)
Published: May 15, 2024
Abstract
Beyond
mere
prognostication,
optimal
biomarkers
of
aging
provide
insights
into
qualitative
and
quantitative
features
biological
might,
therefore,
offer
useful
information
for
the
testing
and,
ultimately,
clinical
use
gerotherapeutics.
We
aimed
to
develop
a
proteomic
clock
(PAC)
all‐cause
mortality
risk
as
proxy
age.
Data
were
from
UK
Biobank
Pharma
Proteomics
Project,
including
53,021
participants
aged
between
39
70
years
2923
plasma
proteins
assessed
using
Olink
Explore
3072
assay®.
10.9%
died
during
mean
follow‐up
13.3
years,
with
age
at
death
70.1
years.
The
Spearman
correlation
PAC
chronological
was
0.77.
showed
robust
age‐adjusted
associations
predictions
onset
various
diseases
in
general
disease‐free
participants.
associated
deviation
enriched
several
processes
related
hallmarks
aging.
Our
results
expand
previous
findings
by
showing
that
acceleration,
based
on
PAC,
strongly
predicts
incident
disease
outcomes.
Particularly,
it
facilitates
evaluation
multiple
conditions
population,
thereby,
contributing
prevention
initial
diseases,
which
vary
among
individuals
may
subsequently
lead
additional
comorbidities.
Aging,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
With
the
global
population
aging
at
an
unprecedented
rate,
there
is
a
need
to
extend
healthy
productive
life
span.
This
review
examines
how
Deep
Learning
(DL)
and
Generative
Artificial
Intelligence
(GenAI)
are
used
in
biomarker
discovery,
deep
clock
development,
geroprotector
identification
generation
of
dual-purpose
therapeutics
targeting
disease.
The
paper
explores
emergence
multimodal,
multitasking
research
systems
highlighting
promising
future
directions
for
GenAI
human
animal
research,
as
well
clinical
application
longevity
medicine.
