A unifying perspective on neural manifolds and circuits for cognition

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(6), P. 363 - 377

Published: April 13, 2023

Language: Английский

---

Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model

Neuron, Journal Year: 2021, Volume and Issue: 109(9), P. 1567 - 1581.e12

Published: March 30, 2021

Across a range of motor and cognitive tasks, cortical activity can be accurately described by low-dimensional dynamics unfolding from specific initial conditions on every trial. These "preparatory states" largely determine the subsequent evolution both neural behavior, their importance raises questions regarding how they are, or ought to be, set. Here, we formulate preparation as optimal anticipatory control future movements show that solution requires form internal feedback circuit dynamics. In contrast simple feedforward strategy, enables fast movement selectively controlling state in small subspace matters for upcoming movement. Feedback but not explains orthogonality between preparatory observed reaching monkeys. We propose model which is implemented thalamo-cortical loop gated basal ganglia.

Language: Английский

---

Translational opportunities and challenges of invasive electrodes for neural interfaces

Nature Biomedical Engineering, Journal Year: 2023, Volume and Issue: 7(4), P. 424 - 442

Published: April 20, 2023

Language: Английский

---

Information-processing dynamics in neural networks of macaque cerebral cortex reflect cognitive state and behavior

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(2)

Published: Jan. 5, 2023

One of the essential functions biological neural networks is processing information. This includes everything from sensory information to perceive environment, up motor interact with environment. Due methodological limitations, it has been historically unclear how changes during different cognitive or behavioral states and what extent processed within between network neurons in brain areas. In this study, we leverage recent advances calculation dynamics explore neural-level frontoparietal areas AIP, F5, M1 a delayed grasping task performed by three macaque monkeys. While was high all task, interareal varied widely: During visuomotor transformation, AIP F5 formed reciprocally connected unit, while no present memory period. Movement execution globally across predominance feedback direction. Furthermore, fine-scale structure reconfigured at neuron level response conditions, despite differences overall amount present. These results suggest that dynamically form higher-order units according demand information-processing hierarchically organized level, coarse determining state finer reflecting conditions.

Language: Английский

---

Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1020 - 1036

Published: April 1, 2023

Language: Английский

---