Spatial and temporal scales of dopamine transmission

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(6), P. 345 - 358

Published: April 9, 2021

Language: Английский

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Striatal dopamine mediates hallucination-like perception in mice

Science, Journal Year: 2021, Volume and Issue: 372(6537)

Published: April 1, 2021

How to model hallucinations in mice There has not been enough progress our understanding of the basic mechanisms underlying psychosis. Studying psychotic disorders animal models is difficult because diagnosis relies on self-reported symptoms that can only be assessed humans. Schmack et al. developed a paradigm probe and rigorously measure experimentally controlled rodents (see Perspective by Matamales). Using dopamine-sensor measurements circuit pharmacological manipulations, they demonstrated brain link between excessive dopamine hallucination-like experience. This could potentially useful as translational common described various psychiatric disorders. It may also help development new therapeutic approaches based anatomically selective modulation function. Science , this issue p. eabf4740 ; see 33

Language: Английский

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Classification of Midbrain Dopamine Neurons Using Single-Cell Gene Expression Profiling Approaches

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 43(3), P. 155 - 169

Published: Feb. 11, 2020

Language: Английский

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Dopamine release in the nucleus accumbens core signals perceived saliency

Current Biology, Journal Year: 2021, Volume and Issue: 31(21), P. 4748 - 4761.e8

Published: Sept. 15, 2021

Language: Английский

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Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes

eLife, Journal Year: 2018, Volume and Issue: 7

Published: Nov. 13, 2018

Extinction of fear responses is critical for adaptive behavior and deficits in this form safety learning are hallmark anxiety disorders. However, the neuronal mechanisms that initiate extinction largely unknown. Here we show, using single-unit electrophysiology cell-type specific fiber photometry, dopamine neurons ventral tegmental area (VTA) activated by omission aversive unconditioned stimulus (US) during extinction. This signal occurred specifically beginning when US unexpected, correlated strongly with learning. Furthermore, temporally-specific optogenetic inhibition or excitation at time revealed both necessary for, sufficient to accelerate, normal These results identify a prediction error-like reveal crucial role DA

Language: Английский

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Mesolimbic dopamine release conveys causal associations

Science, Journal Year: 2022, Volume and Issue: 378(6626)

Published: Dec. 8, 2022

Learning to predict rewards based on environmental cues is essential for survival. It believed that animals learn by updating predictions whenever the outcome deviates from expectations, and such reward prediction errors (RPEs) are signaled mesolimbic dopamine system-a key controller of learning. However, instead learning prospective RPEs, can infer retrospective cause rewards. Hence, whether conveys a causal associative signal sometimes resembles RPE remains unknown. We developed an algorithm found release associations but not RPE, thereby challenging dominant theory Our results reshape conceptual biological framework

Language: Английский

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Neuromodulation in circuits of aversive emotional learning

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(10), P. 1586 - 1597

Published: Sept. 24, 2019

Language: Английский

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State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(11), P. 1820 - 1833

Published: Oct. 14, 2019

Language: Английский

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VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 25(1), P. 86 - 97

Published: Dec. 2, 2021

Language: Английский

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Unique functional responses differentially map onto genetic subtypes of dopamine neurons

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(10), P. 1762 - 1774

Published: Aug. 3, 2023

Abstract Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli. neuron diversity has been observed based on molecular expression profiles; however, whether different functions map onto such genetic subtypes remains unclear. In this study, we established that three dopamine within the substantia nigra pars compacta, of Slc17a6 ( Vglut2 ), Calb1 Anxa1 , each have a unique set responses stimuli accelerations decelerations, these signaling patterns highly correlated between somas axons subtypes. Remarkably, reward were almost entirely absent in + subtype, which instead displayed acceleration-correlated signaling. Our findings establish connection functional demonstrate can serve as common framework dissect dopaminergic functions.

Language: Английский

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