Dopamine and fear memory formation in the human amygdala DOI Creative Commons
Andreas Frick, Johannes Björkstrand, Mark Lubberink

et al.

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 27(3), P. 1704 - 1711

Published: Dec. 3, 2021

Abstract Learning which environmental cues that predict danger is crucial for survival and accomplished through Pavlovian fear conditioning. In humans rodents alike, conditioning amygdala-dependent rests on similar neurocircuitry. Rodent studies have implicated a causative role dopamine in the amygdala during memory formation, but of aversive learning unclear. Here, we show release striatum humans. Using simultaneous positron emission tomography functional magnetic resonance imaging, demonstrate amount linked to strength conditioned responses linearly coupled learning-induced activity amygdala. Thus, like rodents, formation memories seems be facilitated by endogenous release, supporting an evolutionary conserved neurochemical mechanism formation.

Language: Английский

Classification of Midbrain Dopamine Neurons Using Single-Cell Gene Expression Profiling Approaches DOI
Jean‐François Poulin, Zachary Gaertner, Oscar Andrés Moreno-Ramos

et al.

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 43(3), P. 155 - 169

Published: Feb. 11, 2020

Language: Английский

Citations

203

Estimation of Current and Future Physiological States in Insular Cortex DOI
Yoav Livneh,

Arthur U. Sugden,

Joseph C. Madara

et al.

Neuron, Journal Year: 2020, Volume and Issue: 105(6), P. 1094 - 1111.e10

Published: Jan. 16, 2020

Language: Английский

Citations

194

Imaging Neurotransmitter and Neuromodulator Dynamics In Vivo with Genetically Encoded Indicators DOI Creative Commons
Bernardo L. Sabatini, Lin Tian

Neuron, Journal Year: 2020, Volume and Issue: 108(1), P. 17 - 32

Published: Oct. 1, 2020

Language: Английский

Citations

178

Mesolimbic dopamine release conveys causal associations DOI Open Access
Huijeong Jeong, Annie Taylor, Joseph R Floeder

et al.

Science, Journal Year: 2022, Volume and Issue: 378(6626)

Published: Dec. 8, 2022

Learning to predict rewards based on environmental cues is essential for survival. It believed that animals learn by updating predictions whenever the outcome deviates from expectations, and such reward prediction errors (RPEs) are signaled mesolimbic dopamine system-a key controller of learning. However, instead learning prospective RPEs, can infer retrospective cause rewards. Hence, whether conveys a causal associative signal sometimes resembles RPE remains unknown. We developed an algorithm found release associations but not RPE, thereby challenging dominant theory Our results reshape conceptual biological framework

Language: Английский

Citations

171

Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators DOI
Zhaofa Wu, Dayu Lin, Yulong Li

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(5), P. 257 - 274

Published: March 31, 2022

Language: Английский

Citations

165

The emergence and influence of internal states DOI Creative Commons
Steven W. Flavell, Nadine Gogolla, Matthew Lovett-Barron

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(16), P. 2545 - 2570

Published: May 27, 2022

Language: Английский

Citations

148

Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors DOI Creative Commons
Carole Morel, Sarah Montgomery, Long Li

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: March 22, 2022

Abstract Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone comorbid conditions. Here, utilizing the chronic social defeat stress (CSDS) paradigm that induces singular or combined anxiety- depressive-like phenotypes mice, we show ventral tegmental area (VTA) dopamine projecting to basolateral amygdala (BLA) selectively but not depression-like behaviors. Using circuit-dissecting ex vivo electrophysiology fiber photometry approaches, establish expression of anxiety-like, depressive-like, negatively correlated VTA → BLA neuron activity. Further, our optogenetic studies demonstrate causal link between such neuronal activity anxiety-like Overall, these data functional role for neurons bi-directionally controlling only anxiety-alone, also anxiety-depressive conditions mice.

Language: Английский

Citations

112

Dopamine subsystems that track internal states DOI Creative Commons
James C. R. Grove, Lindsay Gray,

Naymalis La Santa Medina

et al.

Nature, Journal Year: 2022, Volume and Issue: 608(7922), P. 374 - 380

Published: July 13, 2022

Food and water are rewarding in part because they satisfy our internal needs

Language: Английский

Citations

94

Unraveling the dynamics of dopamine release and its actions on target cells DOI Creative Commons
Tanya Sippy, Nicolas X. Tritsch

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(3), P. 228 - 239

Published: Jan. 10, 2023

Language: Английский

Citations

48

Habitual daily intake of a sweet and fatty snack modulates reward processing in humans DOI Creative Commons
Sharmili Edwin Thanarajah, Alexandra G. DiFeliceantonio, Kerstin Albus

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(4), P. 571 - 584.e6

Published: March 22, 2023

Western diets rich in fat and sugar promote excess calorie intake weight gain; however, the underlying mechanisms are unclear. Despite a well-documented association between obesity altered brain dopamine function, it remains elusive whether these alterations (1) pre-existing, increasing individual susceptibility to gain, (2) secondary obesity, or (3) directly attributable repeated exposure western diet. To close this gap, we performed randomized, controlled study (NCT05574660) with normal-weight participants exposed high-fat/high-sugar snack low-fat/low-sugar for 8 weeks addition their regular The intervention decreased preference low-fat food while response associative learning independent of cues reward. These were changes body metabolic parameters, indicating direct effect high-fat, high-sugar foods on neurobehavioral adaptations that may increase risk overeating gain.

Language: Английский

Citations

47