The protective effect of operant social reward on cocaine self-administration, choice, and relapse is dependent on delay and effort for the social reward

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 46(13), P. 2350 - 2357

Published: Aug. 16, 2021

Language: Английский

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The study of active avoidance: A platform for discussion

Neuroscience & Biobehavioral Reviews, Journal Year: 2019, Volume and Issue: 107, P. 229 - 237

Published: Sept. 8, 2019

Language: Английский

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An operant social self-administration and choice model in rats

Nature Protocols, Journal Year: 2020, Volume and Issue: 15(4), P. 1542 - 1559

Published: March 20, 2020

Language: Английский

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Animal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review

Pharmacological Reviews, Journal Year: 2021, Volume and Issue: 73(3), P. 1050 - 1083

Published: July 1, 2021

Relapse to drug use during abstinence is a defining feature of addiction. During the last several decades, this clinical scenario has been studied at preclinical level using classic relapse/reinstatement models in which seeking assessed after experimenter-imposed home-cage forced or extinction drug-reinforced responding self-administration chambers. To date, however, results from studies rat have yet result Food and Drug Administration–approved medications for relapse prevention. The reasons state affairs are complex multifaceted, but one potential reason that, humans, often self-imposed voluntary occurs either because negative consequences outweigh drug's rewarding effects availability nondrug alternative rewards that chosen over drug. Based on these considerations, we others recently developed abstinence, achieved by introducing adverse taking (punishment) (electric barrier) providing mutually exclusive choices between self-administered (palatable food social interaction). In review, provide an overview translationally relevant discuss recent neuropharmacological findings models. We also sex as biological variable, future directions, implications Our main conclusion mechanisms controlling different reinstatement extinction.

Significance Statement

This review describes rewards. discusses directions implications.

Language: Английский

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Is addiction a brain disease? A plea for agnosticism and heterogeneity

Psychopharmacology, Journal Year: 2021, Volume and Issue: 239(4), P. 993 - 1007

Published: Nov. 26, 2021

Language: Английский

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