Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice DOI Creative Commons

Man Xue,

Wantong Shi,

Si-Bo Zhou

et al.

Molecular Pain, Journal Year: 2022, Volume and Issue: 18

Published: March 4, 2022

The anterior cingulate cortex (ACC) is located in the frontal part of cortex, and plays important roles pain perception emotion. thalamocortical pathway major sensory input to ACC. Previous studies have show that several different thalamic nuclei receive projection fibers from spinothalamic tract, turn send efferents ACC by using neural tracers optical imaging methods. Most these were performed monkeys, cats, rats, few reported systematically adult mice. Adult mice, especially genetically modified provided molecular synaptic mechanisms for cortical plasticity modulation In present study, we utilized rabies virus-based retrograde tracing system map thalamic-anterior monosynaptic inputs We also combined with a new high-throughput VISoR technique generate three-dimensional whole-brain reconstruction, thalamus. found neurons received direct projections sub-nuclei thalamus, including anterior, ventral, medial, lateral, midline, intralaminar nuclei. These findings provide key anatomic evidences connection between thalamus

Language: Английский

Sound induces analgesia through corticothalamic circuits DOI Open Access
Wenjie Zhou, Chonghuan Ye, Haitao Wang

et al.

Science, Journal Year: 2022, Volume and Issue: 377(6602), P. 198 - 204

Published: July 7, 2022

Sound-including music and noise-can relieve pain in humans, but the underlying neural mechanisms remain unknown. We discovered that analgesic effects of sound depended on a low (5-decibel) signal-to-noise ratio (SNR) relative to ambient noise mice. Viral tracing, microendoscopic calcium imaging, multitetrode recordings freely moving mice showed low-SNR sounds inhibited glutamatergic inputs from auditory cortex (ACxGlu) thalamic posterior (PO) ventral (VP) nuclei. Optogenetic or chemogenetic inhibition ACxGlu→PO ACxGlu→VP circuits mimicked sound-induced analgesia inflamed hindpaws forepaws, respectively. Artificial activation these two abolished analgesia. Our study reveals corticothalamic sound-promoted by deciphering role system processing.

Language: Английский

Citations

73
An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences DOI
Qian Song, Anqi Wei, Hua‐Dong Xu

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(2), P. 272 - 285

Published: Jan. 3, 2024

Language: Английский

Citations

38
Brain region–specific action of ketamine as a rapid antidepressant DOI
Min Chen,

Shuangshuang Ma,

Hanxiao Liu

et al.

Science, Journal Year: 2024, Volume and Issue: 385(6709)

Published: Aug. 8, 2024

Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of its molecular target,

Language: Английский

Citations

25
TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice DOI
Xuyi Li,

Shi-Ya Zhang,

Yi-Zhou Hong

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(11), P. 1795 - 1814.e10

Published: March 21, 2024

Language: Английский

Citations

24
A mesocortical glutamatergic pathway modulates neuropathic pain independent of dopamine co-release DOI Creative Commons
Miao Li, Guang Yang

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 20, 2024

Dysfunction in the mesocortical pathway, connecting ventral tegmental area (VTA) to prefrontal cortex, has been implicated chronic pain. While extensive research focused on role of dopamine, contribution glutamatergic signaling pain modulation remains unknown. Using vivo calcium imaging, we observe diminished VTA activity targeting prelimbic cortex (PL) a mouse model neuropathic Optogenetic activation terminals PL alleviates pain, whereas inhibiting these naïve mice induces pain-like responses. Importantly, this pain-modulating effect is independent dopamine co-release, as demonstrated by CRISPR/Cas9-mediated gene deletion. Furthermore, show that neurons primarily project excitatory PL, and their restores outputs anterior cingulate key region involved processing. These findings reveal distinct pathway critically modulates signaling.

Language: Английский

Citations

16
Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen DOI
Xia Zhu,

Ji-Ye Huang,

Wanying Dong

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(3), P. 471 - 483

Published: Jan. 30, 2024

Language: Английский

Citations

16
Sexually dimorphic dopaminergic circuits determine sex preference DOI
Anqi Wei,

Anran Zhao,

Chaowen Zheng

et al.

Science, Journal Year: 2025, Volume and Issue: 387(6730)

Published: Jan. 9, 2025

Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex remain unclear. In this study, we show that both male female mice exhibit but shift to when facing survival threats; their mediated by the dimorphic changes in excitability of ventral tegmental area dopaminergic (VTA DA ) neurons. males, VTA projections nucleus accumbens (NAc) mediate preference, those medial preoptic preference. females, firing-pattern (phasic-like versus tonic-like) alteration -NAc projection determines sociosexual preferences. These findings define neurons as a key node decision-making reveal sexually circuit underlying

Language: Английский

Citations

6
Neuroplasticity related to chronic pain and its modulation by microglia DOI Creative Commons
Shin‐ichiro Hiraga, Takahide Itokazu,

Mariko Nishibe

et al.

Inflammation and Regeneration, Journal Year: 2022, Volume and Issue: 42(1)

Published: May 3, 2022

Neuropathic pain is often chronic and can persist after overt tissue damage heals, suggesting that its underlying mechanism involves the alteration of neuronal function. Such an be a direct consequence nerve or result neuroplasticity secondary to tissues neurons. Recent studies have shown linked causing neuropathic in response damage, which may occur adjacent remotely from site injury. Furthermore, revealed relevant modulated by microglia, resident immune cells central nervous system (CNS). Microglia directly contribute synaptic remodeling altering circuits, indirectly through property changes, including secretion growth factors. We herein highlight mechanisms somatosensory circuit spinal dorsal horn, thalamus, cortex associated with following injury peripheral (PNS) CNS. also discuss dynamic functions microglia shaping related pain. suggest further understanding post-injury ectopic plasticity circuits shed light on differential nociceptive, neuropathic, nociplastic-type While one prominent roles played appears modulation neuroplasticity. Therefore, future molecular- genetics-based address microglia-mediated development novel therapies for

Language: Английский

Citations

49
Janus effect of the anterior cingulate cortex: Pain and emotion DOI Creative Commons
Sarah H. Journée, Victor Mathis, Clémentine Fillinger

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 153, P. 105362 - 105362

Published: Aug. 16, 2023

Language: Английский

Citations

24
Neuronal and Molecular Mechanisms Underlying Chronic Pain and Depression Comorbidity in the Paraventricular Thalamus DOI Creative Commons

Mengqiao Cui,

Ran Ji, Lingzhen Song

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(13), P. e1752232024 - e1752232024

Published: Feb. 20, 2024

Patients with chronic pain often develop comorbid depressive symptoms, which makes the symptoms more complicated and refractory. However, underlying mechanisms are poorly known. Here, in a repeated complete Freund's adjuvant (CFA) male mouse model, we reported specific regulatory role of paraventricular thalamic nucleus (PVT) glutamatergic neurons, particularly anterior PVT (PVA) mediating depression comorbidity (CDC). Our c-Fos protein staining observed increased PVA neuronal activity CFA-CDC mice. In wild-type mice, chemogenetic activation neurons was sufficient to decrease 50% paw withdrawal thresholds (50% PWTs), while depressive-like behaviors evaluated immobile time tail suspension test (TST) forced swim (FST) could only be achieved by activation. Chemogenetic inhibition reversed decreased PWTs CFA mice without TST FST immobility Surprisingly, chemogenetically inhibiting failed reverse PWTs, restored rapid-onset antidepressant S-ketamine. Further behavioral tests restraint stress indicated that neuron S-ketamine independently alleviate sensory affective pain. Molecular profiling pharmacological studies revealed 5-hydroxytryptamine receptor 1D (Htr1d) pain-related engram as potential target for treating CDC. These findings identified novel CDC molecular provided insight into neuropathology under state related drug development.

Language: Английский

Citations

15