Molecular Pain,
Journal Year:
2022,
Volume and Issue:
18
Published: March 4, 2022
The
anterior
cingulate
cortex
(ACC)
is
located
in
the
frontal
part
of
cortex,
and
plays
important
roles
pain
perception
emotion.
thalamocortical
pathway
major
sensory
input
to
ACC.
Previous
studies
have
show
that
several
different
thalamic
nuclei
receive
projection
fibers
from
spinothalamic
tract,
turn
send
efferents
ACC
by
using
neural
tracers
optical
imaging
methods.
Most
these
were
performed
monkeys,
cats,
rats,
few
reported
systematically
adult
mice.
Adult
mice,
especially
genetically
modified
provided
molecular
synaptic
mechanisms
for
cortical
plasticity
modulation
In
present
study,
we
utilized
rabies
virus-based
retrograde
tracing
system
map
thalamic-anterior
monosynaptic
inputs
We
also
combined
with
a
new
high-throughput
VISoR
technique
generate
three-dimensional
whole-brain
reconstruction,
thalamus.
found
neurons
received
direct
projections
sub-nuclei
thalamus,
including
anterior,
ventral,
medial,
lateral,
midline,
intralaminar
nuclei.
These
findings
provide
key
anatomic
evidences
connection
between
thalamus
Neuroscience Bulletin,
Journal Year:
2022,
Volume and Issue:
38(4), P. 440 - 452
Published: March 5, 2022
Pain
is
an
unpleasant
sensory
and
emotional
experience
associated
with,
or
resembling
that
actual
potential
tissue
damage.
The
processing
of
pain
involves
complicated
modulation
at
the
levels
periphery,
spinal
cord,
brain.
pathogenesis
chronic
still
not
fully
understood,
which
makes
clinical
treatment
challenging.
Optogenetics,
combines
optical
genetic
technologies,
can
precisely
intervene
in
activity
specific
groups
neurons
elements
related
circuits.
Taking
advantage
optogenetics,
researchers
have
achieved
a
body
new
findings
shed
light
on
cellular
circuit
mechanisms
transmission,
modulation,
both
periphery
central
nervous
system.
In
this
review,
we
summarize
recent
research
using
optogenetic
approaches
discuss
their
significance
understanding
pain.
Cell Reports,
Journal Year:
2023,
Volume and Issue:
42(4), P. 112290 - 112290
Published: March 21, 2023
Light
has
been
shown
to
relieve
pain,
but
the
underlying
neural
mechanisms
remain
unknown.
Here,
we
show
that
low-intensity
(200
lux)
green
light
treatment
exerts
antinociceptive
effects
through
a
circuit
from
visual
cortex
projecting
anterior
cingulate
(ACC)
in
mice.
Specifically,
viral
tracing,
vivo
two-photon
calcium
imaging,
and
fiber
photometry
recordings
activated
glutamatergic
projections
medial
part
of
secondary
(V2MGlu)
GABAergic
neurons
ACC,
which
drives
inhibition
local
(V2MGlu→ACCGABA→Glu).
Optogenetic
or
chemogenetic
activation
V2MGlu→ACCGABA→Glu
mimics
green-light-induced
antinociception
both
neuropathic
inflammatory
pain
model
Artificial
ACC-projecting
V2MGlu
abolishes
induced
by
light.
Taken
together,
our
study
shows
V2M-ACC
as
potential
candidate
mediating
effects.
iScience,
Journal Year:
2023,
Volume and Issue:
26(4), P. 106332 - 106332
Published: March 4, 2023
The
mechanism
by
which
acute
pain
or
itch
information
at
the
periphery
is
processed
in
primary
somatosensory
cortex
(S1)
remains
unclear.
To
elucidate
this,
we
used
a
viral-mediated
targeted-recombination-in-active
population
system
to
target
S1
neuronal
ensembles
that
are
active
during
sensations.
We
induced
expression
of
excitatory
inhibitory
designer
receptors
exclusively
activated
drugs
pain-
itch-related
neurons.
identified
populations
mice
regulate
sensory
components
and
hind
paw
region.
Notably,
circuit
between
pain-related
neurons
parafascicular
nucleus
contributed
hyperalgesia
anxiety-like
behavior.
propose
plays
an
essential
role
affective
responses
noxious
stimuli,
such
as
pain.
Molecular Pain,
Journal Year:
2022,
Volume and Issue:
18
Published: March 4, 2022
The
anterior
cingulate
cortex
(ACC)
is
located
in
the
frontal
part
of
cortex,
and
plays
important
roles
pain
perception
emotion.
thalamocortical
pathway
major
sensory
input
to
ACC.
Previous
studies
have
show
that
several
different
thalamic
nuclei
receive
projection
fibers
from
spinothalamic
tract,
turn
send
efferents
ACC
by
using
neural
tracers
optical
imaging
methods.
Most
these
were
performed
monkeys,
cats,
rats,
few
reported
systematically
adult
mice.
Adult
mice,
especially
genetically
modified
provided
molecular
synaptic
mechanisms
for
cortical
plasticity
modulation
In
present
study,
we
utilized
rabies
virus-based
retrograde
tracing
system
map
thalamic-anterior
monosynaptic
inputs
We
also
combined
with
a
new
high-throughput
VISoR
technique
generate
three-dimensional
whole-brain
reconstruction,
thalamus.
found
neurons
received
direct
projections
sub-nuclei
thalamus,
including
anterior,
ventral,
medial,
lateral,
midline,
intralaminar
nuclei.
These
findings
provide
key
anatomic
evidences
connection
between
thalamus
