A thalamocortical substrate for integrated information via critical synchronous bursting DOI Creative Commons
Brandon R. Munn, Eli J. Müller, Jaan Aru

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(46)

Published: Nov. 8, 2023

Understanding the neurobiological mechanisms underlying consciousness remains a significant challenge. Recent evidence suggests that coupling between distal–apical and basal–somatic dendrites in thick-tufted layer 5 pyramidal neurons (L5 PN ), regulated by nonspecific-projecting thalamus, is crucial for consciousness. Yet, it uncertain whether this thalamocortical mechanism can support emergent signatures of consciousness, such as integrated information. To address question, we constructed biophysical network dual-compartment L5 , with dendrosomatic controlled thalamic inputs. Our findings demonstrate information maximized when nonspecific inputs drive system into regime time-varying synchronous bursting. Here, exhibits variable spiking dynamics broad pairwise correlations, supporting enhanced Further, observed peak aligns criticality empirically bursting rates. These results suggest core mammalian brain may be evolutionarily configured to optimize effective processing, providing potential neuronal integrates microscale theories macroscale

Language: Английский

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex DOI Creative Commons
Justine Y. Hansen, Golia Shafiei, Ross D. Markello

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(11), P. 1569 - 1581

Published: Oct. 27, 2022

Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative 19 transporters across nine different neurotransmitter systems. We found that profiles align with structural connectivity mediate function, including neurophysiological oscillatory dynamics resting-state hemodynamic functional connectivity. Using Neurosynth cognitive atlas, uncovered topographic gradient overlapping distributions separates extrinsic intrinsic psychological processes. Finally, both expected novel associations between cortical abnormality patterns 13 disorders. replicated all findings an independently collected autoradiography dataset. This work demonstrates chemoarchitecture shapes brain structure providing new direction for studying multi-scale organization.

Language: Английский

Citations

423
How critical is brain criticality? DOI
Jordan O’Byrne, Karim Jerbi

Trends in Neurosciences, Journal Year: 2022, Volume and Issue: 45(11), P. 820 - 837

Published: Sept. 9, 2022

Language: Английский

Citations

167
The ascending arousal system shapes neural dynamics to mediate awareness of cognitive states DOI Creative Commons
Brandon R. Munn, Eli J. Műller, Gabriel Wainstein

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Oct. 14, 2021

Abstract Models of cognitive function typically focus on the cerebral cortex and hence overlook functional links to subcortical structures. This view does not consider role highly-conserved ascending arousal system’s computational capacities it provides brain. We test hypothesis that system modulates cortical neural gain alter low-dimensional energy landscape dynamics. Here we use spontaneous magnetic resonance imaging data study phasic bursts in both locus coeruleus basal forebrain, demonstrating precise time-locked relationships between brainstem activity, landscapes, network topology, spatiotemporal travelling waves. extend our analysis a cohort experienced meditators demonstrate coeruleus-mediated dynamics were associated with internal shifts conscious awareness. Together, these results present brain organization highlights shaping

Language: Английский

Citations

134
The impact of the human thalamus on brain-wide information processing DOI
James M. Shine, Laura D. Lewis, Douglas D. Garrett

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(7), P. 416 - 430

Published: May 26, 2023

Language: Английский

Citations

130
Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight DOI
Jacob W. Vogel, Nick Corriveau‐Lecavalier, Nicolai Franzmeier

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(10), P. 620 - 639

Published: Aug. 24, 2023

Language: Английский

Citations

80
Local molecular and global connectomic contributions to cross-disorder cortical abnormalities DOI Creative Commons
Justine Y. Hansen, Golia Shafiei, Jacob W. Vogel

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 10, 2022

Abstract Numerous brain disorders demonstrate structural abnormalities, which are thought to arise from molecular perturbations or connectome miswiring. The unique and shared contributions of these connectomic vulnerabilities remain unknown, has yet be studied in a single multi-disorder framework. Using MRI morphometry the ENIGMA consortium, we construct maps cortical abnormalities for thirteen neurodevelopmental, neurological, psychiatric N = 21,000 participants 26,000 controls, collected using harmonised processing protocol. We systematically compare multiple micro-architectural measures, including gene expression, neurotransmitter density, metabolism, myelination (molecular vulnerability), as well global measures number connections, centrality, connection diversity (connectomic vulnerability). find relationship between vulnerability white-matter architecture that drives disorder profiles. Local attributes, particularly receptor profiles, constitute best predictors both disorder-specific morphology cross-disorder similarity. Finally, consistently subtended by small subset network epicentres bilateral sensory-motor, inferior temporal lobe, precuneus, superior parietal cortex. Collectively, our results highlight how local attributes connectivity jointly shape abnormalities.

Language: Английский

Citations

73
Information decomposition and the informational architecture of the brain DOI Creative Commons
Andrea I. Luppi, Fernando Rosas, Pedro A. M. Mediano

et al.

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(4), P. 352 - 368

Published: Jan. 9, 2024

To explain how the brain orchestrates information-processing for cognition, we must understand information itself. Importantly, is not a monolithic entity. Information decomposition techniques provide way to split into its constituent elements: unique, redundant, and synergistic information. We review disentangling redundant interactions redefining our understanding of integrative function neural organisation. navigates trade-offs between redundancy synergy, converging evidence integrating structural, molecular, functional underpinnings synergy redundancy; their roles in cognition computation; they might arise over evolution development. Overall, provides guiding principle informational architecture cognition.

Language: Английский

Citations

62
Dynamic predictive coding: A model of hierarchical sequence learning and prediction in the neocortex DOI Creative Commons
Linxing Preston Jiang, Rajesh P. N. Rao

PLoS Computational Biology, Journal Year: 2024, Volume and Issue: 20(2), P. e1011801 - e1011801

Published: Feb. 8, 2024

We introduce dynamic predictive coding, a hierarchical model of spatiotemporal prediction and sequence learning in the neocortex. The assumes that higher cortical levels modulate temporal dynamics lower levels, correcting their predictions using errors. As result, form representations encode sequences at shorter timescales (e.g., single step) while longer an entire sequence). tested this two-level neural network, where top-down modulation creates low-dimensional combinations set learned to explain input sequences. When trained on natural videos, lower-level neurons developed space-time receptive fields similar those simple cells primary visual cortex higher-level responses spanned timescales, mimicking response hierarchies cortex. Additionally, network’s representation exhibited both postdictive effects resembling observed motion processing humans flash-lag illusion). coupled with associative memory emulating role hippocampus, allowed episodic memories be stored retrieved, supporting cue-triggered recall activity extended three progressively more abstract along hierarchy. Taken together, our results suggest can interpreted as coding based generative world.

Language: Английский

Citations

18
A computational model of neurodegeneration in Alzheimer’s disease DOI Creative Commons
David T. Jones, Val J. Lowe, Jonathan Graff‐Radford

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: March 28, 2022

Abstract Disruption of mental functions in Alzheimer’s disease (AD) and related disorders is accompanied by selective degeneration brain regions. These regions comprise large-scale ensembles cells organized into systems for functioning, however the relationship between clinical symptoms dementia, patterns neurodegeneration, functional not clear. Here we present a model association dementia degenerative anatomy using F18-fluorodeoxyglucose PET dimensionality reduction techniques two cohorts patients with AD. This reflected simple information processing-based description macroscale which link to AD physiology, networks, abilities. We further apply normal aging seven diseases functions. propose global processing that links neuroanatomy, cognitive neuroscience neurology.

Language: Английский

Citations

59
Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness DOI Creative Commons
Andrea I. Luppi, Pedro A. M. Mediano, Fernando Rosas

et al.

Communications Biology, Journal Year: 2022, Volume and Issue: 5(1)

Published: April 20, 2022

The human brain entertains rich spatiotemporal dynamics, which are drastically reconfigured when consciousness is lost due to anaesthesia or disorders of (DOC). Here, we sought identify the neurobiological mechanisms that explain how transient pharmacological intervention and chronic neuroanatomical injury can lead common reconfigurations neural activity. We developed systematically perturbed a neurobiologically realistic model whole-brain haemodynamic signals. By incorporating PET data about cortical distribution GABA receptors, our computational reveals key role spatially-specific local inhibition for reproducing functional MRI activity observed during with GABA-ergic agent propofol. Additionally, diffusion obtained from DOC patients dynamics characterise loss also emerge randomised connectivity. Our results generalise between datasets, demonstrating increased connectome perturbation represent distinct paths towards characteristic unconscious brain.

Language: Английский

Citations

48