Network analysis of the human structural connectome including the brainstem DOI Creative Commons
Salma Salhi,

Youssef Kora,

Gisu Ham

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(4), P. e0272688 - e0272688

Published: April 6, 2023

The underlying anatomical structure is fundamental to the study of brain networks, but role brainstem from a structural perspective not very well understood. We conduct computational and graph-theoretical human connectome incorporating variety subcortical structures including brainstem. Our scheme involves use Python DIPY Nibabel libraries develop connectomes using 100 healthy adult subjects. then compute degree, eigenvector, betweenness centralities identify several highly connected find that ranks highest across all examined metrics, result holds even when connectivity matrix normalized by volume. also investigated some global topological features in connectomes, such as balance integration segregation, found domination generally causes networks become less integrated segregated. results highlight importance network analyses.

Language: Английский

A synergistic core for human brain evolution and cognition DOI
Andrea I. Luppi, Pedro A. M. Mediano, Fernando Rosas

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(6), P. 771 - 782

Published: May 26, 2022

Language: Английский

Citations

209
Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape DOI Creative Commons
S. Parker Singleton, Andrea I. Luppi,

Robin Carhart‐Harris

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 3, 2022

Psychedelics including lysergic acid diethylamide (LSD) and psilocybin temporarily alter subjective experience through their neurochemical effects. Serotonin 2a (5-HT2a) receptor agonism by these compounds is associated with more diverse (entropic) brain activity. We postulate that this increase in entropy may arise part from a flattening of the brain's control energy landscape, which can be observed using network theory to quantify required transition between recurrent states. Using states derived existing functional magnetic resonance imaging (fMRI) datasets, we show LSD reduce for state transitions compared placebo. Furthermore, across individuals, reduction correlates frequent increased dynamics. Through analysis incorporates spatial distribution 5-HT2a receptors (obtained publicly available positron emission tomography (PET) data under non-drug conditions), demonstrate an association reduced energy. Our findings provide evidence agonist allow facile temporally More broadly, receptor-informed model impact neuropharmacological manipulation on activity

Language: Английский

Citations

95
Functional geometry of the cortex encodes dimensions of consciousness DOI Creative Commons
Zirui Huang, George A. Mashour, Anthony G. Hudetz

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 5, 2023

Abstract Consciousness is a multidimensional phenomenon, but key dimensions such as awareness and wakefulness have been described conceptually rather than neurobiologically. We hypothesize that of consciousness are encoded in multiple neurofunctional the brain. analyze cortical gradients, which continua brain’s overarching functional geometry, to characterize these dimensions. demonstrate disruptions human – due pharmacological, neuropathological, or psychiatric causes associated with degradation one more major gradients depending on state. Network-specific reconfigurations within gradient space behavioral unresponsiveness various etiologies, spatial correlate temporal disruption structured transitions dynamic brain states. In this work, we therefore provide unifying framework for both health disease.

Language: Английский

Citations

77
Distributed harmonic patterns of structure-function dependence orchestrate human consciousness DOI Creative Commons
Andrea I. Luppi, Jakub Vohryzek, Morten L. Kringelbach

et al.

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: Jan. 28, 2023

Abstract A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals pathological pharmacologically-induced perturbations into distributed patterns structure-function dependence across scales: harmonic modes human structural connectome. We show that coupling a generalisable indicator under bi-directional neuromodulatory control. find increased scales during loss consciousness, whether due to anaesthesia or injury, capable discriminating between behaviourally indistinguishable sub-categories brain-injured patients, tracking presence covert consciousness. The opposite signature characterises altered state induced by LSD ketamine, reflecting psychedelic-induced decoupling function correlating with physiological subjective scores. Overall, connectome decomposition reveals neuromodulation network architecture jointly shape activation scales.

Language: Английский

Citations

69
In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape DOI Creative Commons
Andrea I. Luppi, Justine Y. Hansen, R. Adapa

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(24)

Published: June 14, 2023

To understand how pharmacological interventions can exert their powerful effects on brain function, we need to they engage the brain's rich neurotransmitter landscape. Here, bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating regional distribution of 19 receptors transporters obtained from positron emission tomography, changes in magnetic resonance imaging connectivity 10 different mind-altering drugs: propofol, sevoflurane, ketamine, lysergic acid diethylamide (LSD), psilocybin, N,N-Dimethyltryptamine (DMT), ayahuasca, 3,4-methylenedioxymethamphetamine (MDMA), modafinil, methylphenidate. Our results reveal a many-to-many mapping between psychoactive drugs' function multiple systems. The both anesthetics psychedelics are organized along hierarchical gradients structure function. Last, show that co-susceptibility recapitulates disorder-induced structural alterations. Collectively, these highlight statistical patterns drug-induced reorganization architecture.

Language: Английский

Citations

32
A synergistic workspace for human consciousness revealed by Integrated Information Decomposition DOI Creative Commons
Andrea I. Luppi, Pedro A. M. Mediano, Fernando Rosas

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: July 25, 2023

How is the information-processing architecture of human brain organised, and how does its organisation support consciousness? Here, we combine network science a rigorous information-theoretic notion synergy to delineate ‘synergistic global workspace’, comprising gateway regions that gather synergistic information from specialised modules across brain. This then integrated within workspace widely distributed via broadcaster regions. Through functional MRI analysis, show correspond brain’s default mode network, whereas broadcasters coincide with executive control network. We find loss consciousness due general anaesthesia or disorders corresponds diminished ability integrate information, which restored upon recovery. Thus, coincides breakdown integration work contributes conceptual empirical reconciliation between two prominent scientific theories consciousness, Global Neuronal Workspace Integrated Information Theory, while also advancing our understanding supports through information.

Language: Английский

Citations

31
Reduced emergent character of neural dynamics in patients with a disrupted connectome DOI Creative Commons
Andrea I. Luppi, Pedro A. M. Mediano, Fernando Rosas

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 269, P. 119926 - 119926

Published: Feb. 3, 2023

High-level brain functions are widely believed to emerge from the orchestrated activity of multiple neural systems. However, lacking a formal definition and practical quantification emergence for experimental data, neuroscientists have been unable empirically test this long-standing conjecture. Here we investigate fundamental question by leveraging recently proposed framework known as "Integrated Information Decomposition," which establishes principled information-theoretic approach operationalise quantify in dynamical systems - including human brain. By analysing functional MRI our results show that emergent hierarchical character dynamics is significantly diminished chronically unresponsive patients suffering severe injury. At level, demonstrate capacity positively correlated with extent organisation activity. Furthermore, combining computational approaches network control theory whole-brain biophysical modelling, reduced severely brain-injured can be mechanistically explained disruptions patients' structural connectome. Overall, suggest chronic unresponsiveness resulting injury may related impairment infrastructures required support emergence.

Language: Английский

Citations

25
From neurotransmitters to networks: Transcending organisational hierarchies with molecular-informed functional imaging DOI Creative Commons
Timothy Lawn, Matthew A. Howard, Federico Turkheimer

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 150, P. 105193 - 105193

Published: April 21, 2023

The human brain exhibits complex interactions across micro, meso-, and macro-scale organisational principles. Recent synergistic multi-modal approaches have begun to link micro-scale information systems level dynamics, transcending hierarchies offering novel perspectives into the brain's function dysfunction. Specifically, distribution of properties (such as receptor density or gene expression) can be mapped onto measures from functional MRI provide neurobiological insights. Methodological enrich imaging analyses with molecular are rapidly evolving, several streams research having developed relatively independently, each unique potential explore trans-hierarchical functioning brain. Here, we address three principal - spatial correlation, molecular-enriched network, in-silico whole modelling a critical overview different sources information, how this utilised within fMRI data, merits pitfalls methodology, and, through use key examples, highlight their promise shed new light on domains neuroscientific inquiry.

Language: Английский

Citations

25
The Hopf whole-brain model and its linear approximation DOI Creative Commons
Adrián Ponce‐Alvarez, Gustavo Deco

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 31, 2024

Abstract Whole-brain models have proven to be useful understand the emergence of collective activity among neural populations or brain regions. These combine connectivity matrices, connectomes , with local node dynamics, noise, and, eventually, transmission delays. Multiple choices for dynamics been proposed. Among them, nonlinear oscillators corresponding a supercritical Hopf bifurcation used link and phase amplitude in different states. Here, we studied linear fluctuations this model estimate its stationary statistics, i.e., instantaneous lagged covariances power spectral densities. This approximation—that holds case heterogeneous parameters time-delays—allows analytical estimation statistics it can fast parameter explorations study changes state, due alterations structural connectivity, modulations non-equilibrium dynamics.

Language: Английский

Citations

14
Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies DOI Creative Commons
Andrea I. Luppi, S. Parker Singleton, Justine Y. Hansen

et al.

Nature Biomedical Engineering, Journal Year: 2024, Volume and Issue: 8(9), P. 1142 - 1161

Published: Aug. 5, 2024

Abstract The mechanisms linking the brain’s network structure to cognitively relevant activation patterns remain largely unknown. Here, by leveraging principles of control, we show how architecture human connectome shapes transitions between 123 experimentally defined cognitive maps (cognitive topographies) from NeuroSynth meta-analytic database. Specifically, systematically integrated large-scale multimodal neuroimaging data functional magnetic resonance imaging, diffusion tractography, cortical morphometry and positron emission tomography simulate anatomically guided states can be reshaped neurotransmitter engagement or changes in thickness. Our model incorporates neurotransmitter-receptor density (18 receptors transporters) thickness pertaining a wide range mental health, neurodegenerative, psychiatric neurodevelopmental diagnostic categories (17,000 patients 22,000 controls). results provide comprehensive look-up table charting brain organization chemoarchitecture interact manifest different topographies, establish principled foundation for systematic identification ways promote selective topographies.

Language: Английский

Citations

9