Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract This review underscores the transformative potential of photonic nanomaterials in wearable health technologies, driven by increasing demands for personalized monitoring. Their unique optical and physical properties enable rapid, precise, sensitive real‐time monitoring, outperforming conventional electrical‐based sensors. Integrated into ultra‐thin, flexible, stretchable formats, these materials enhance compatibility with human body, enabling prolonged wear, improved efficiency, reduced power consumption. A comprehensive exploration is provided integration devices, addressing material selection, light‐matter interaction principles, device assembly strategies. The highlights critical elements such as form factors, sensing modalities, data communication, representative examples skin patches contact lenses. These devices precise monitoring management biomarkers diseases or biological responses. Furthermore, advancements approaches have paved way continuum care systems combining multifunctional sensors therapeutic drug delivery mechanisms. To overcome existing barriers, this outlines strategies design, engineering, system integration, machine learning to inspire innovation accelerate adoption next‐generation health, showcasing their versatility digital applications.

Language: Английский

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Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Feb. 11, 2022

Abstract Optogenetic methods provide efficient cell-specific modulations, and the ability of simultaneous neural activation inhibition in same brain region freely moving animals is highly desirable. Here we report bidirectional neuronal activity manipulation accomplished by a wireless, dual-color optogenetic probe synergy with co-expression two spectrally distinct opsins (ChrimsonR stGtACR2) rodent model. The flexible comprises vertically assembled, thin-film microscale light-emitting diodes lateral dimension 125 × 180 µm 2 , showing colocalized red blue emissions enabling chronic vivo operations desirable biocompatibilities. Red or irradiations deterministically evoke silence neurons co-expressing opsins. interferes dopaminergic ventral tegmental area mice, increasing decreasing dopamine levels. Such regulations further generate rewarding aversive behaviors interrogate social interactions among multiple mice. These technologies create numerous opportunities implications for research.

Language: Английский

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The Roles of Optogenetics and Technology in Neurobiology: A Review

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: April 19, 2022

Optogenetic is a technique that combines optics and genetics to control specific neurons. This usually uses adenoviruses encode photosensitive protein. The adenovirus may concentrate in neural region. By shining light on the target nerve region, protein encoded by controlled. Photosensitive proteins controlled can selectively allow ions inside outside cell membrane pass through, resulting inhibition or activation effects. Due high precision minimally invasive, optogenetics has achieved good results many fields, especially field of neuron functions circuits. Significant advances have also been made study clinical diseases. review focuses research neurobiology. These include how use cells, circuits, treat diseases changing state We hoped this will give comprehensive understanding progress

Language: Английский

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Electron Conductive and Transparent Hydrogels for Recording Brain Neural Signals and Neuromodulation

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(9)

Published: Dec. 23, 2022

Recording brain neural signals and optogenetic neuromodulations open frontiers in decoding information neurodegenerative disease therapeutics. Conventional implantable probes suffer from modulus mismatch with biological tissues an irreconcilable tradeoff between transparency electron conductivity. Herein, a strategy is proposed to address these tradeoffs, which generates conductive transparent hydrogels polypyrrole-decorated microgels as cross-linkers. The optical of the electrodes can be attributed special structures that allow light waves bypass microgel particles minimize their interaction. Demonstrated by probing hippocampus rat brains, biomimetic electrode shows prolonged capacity for simultaneous neuromodulation recording signals. More importantly, intriguing brain-machine interaction realized, involves signal input brain, generation, controlling limb behaviors. This breakthrough work represents significant scientific advancement toward developing therapies.

Language: Английский

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Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 22, 2022

Abstract In vivo optogenetics and photopharmacology are two techniques for controlling neuronal activity that have immense potential in neuroscience research. Their applications tether-free groups of animals been limited part due to tools availability. Here, we present a wireless, battery-free, programable multilateral optofluidic platform with user-selected modalities optogenetics, pharmacology photopharmacology. This system features mechanically compliant microfluidic electronic interconnects, capabilities dynamic control over the rates drug delivery real-time programmability, simultaneously up 256 separate devices single cage environment. Our behavioral experiments demonstrate motor behaviors grouped mice through co-located gene controlled photolysis caged glutamate. These systems may expand scope wireless study neural processing animal models.

Language: Английский

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Technologically-assisted communication attenuates inter-brain synchrony

NeuroImage, Journal Year: 2022, Volume and Issue: 264, P. 119677 - 119677

Published: Oct. 13, 2022

The transition to technologically-assisted communication has permeated all facets of human social life; yet, its impact on the brain is still unknown and effects may be particularly intense during periods developmental transitions. Applying a two-brain perspective, current preregistered study utilized hyperscanning EEG measure brain-to-brain synchrony in 62 mother-child pairs at adolescence (child age; M = 12.26, range 10-14) live face-to-face interaction versus remote communication. elicited 9 significant cross-brain links between densely inter-connected frontal temporal areas beta [14-30 Hz]. Mother's right region connected with child's left frontal, temporal, central regions, suggesting regulatory role organizing dynamics. In contrast, only 1 cross-brain-cross-hemisphere link, attenuating robust right-to-right-brain connectivity moments that communicates socio-affective signals. Furthermore, while level behavior was comparable two interactions, brain-behavior associations emerged exchange. Mother-child temporal-temporal linked shared gaze degree child engagement empathic correlated frontal-frontal synchrony. Our findings indicate co-presence underpinned by specific neurobiological processes should studied depth. Much further research needed tease apart whether "Zoom fatigue" experienced technological stem, part, from overload more limited inter-brain connections address potential cost technology for maturation, among youth.

Language: Английский

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HectoSTAR μLED Optoelectrodes for Large‐Scale, High‐Precision In Vivo Opto‐Electrophysiology

Advanced Science, Journal Year: 2022, Volume and Issue: 9(18)

Published: April 22, 2022

Abstract Dynamic interactions within and across brain areas underlie behavioral cognitive functions. To understand the basis of these processes, activities distributed local circuits inside a behaving animal must be synchronously recorded while inputs to are precisely manipulated. Even though recent technological advances have enabled such large‐scale recording capabilities, development high‐spatiotemporal‐resolution modulation techniques accompany those recordings has lagged. A novel neural probe is presented in this work that enables simultaneous electrical monitoring optogenetic manipulation deep neuronal at large scales with high spatiotemporal resolution. The “hectoSTAR” micro‐light‐emitting‐diode (μLED) optoelectrode features 256 electrodes 128 stimulation μLEDs monolithically integrated on surface its four 30‐µm thick silicon micro‐needle shanks, covering volume 1.3‐mm × 0.9‐mm cross‐sectional area located as 6 mm brain. use device mice for dissecting long‐distance network cortical layers hippocampal regions demonstrated. recording‐and‐stimulation capabilities hectoSTAR μLED optoelectrodes will open up new possibilities cellular circuit‐based investigation functions animals.

Language: Английский

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Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: May 30, 2022

Abstract Continuous, real-time monitoring of perfusion after microsurgical free tissue transfer or solid organ allotransplantation procedures can facilitate early diagnosis and intervention for anastomotic thrombosis. Current technologies including Doppler systems, cutaneous O 2 -sensing probes, fluorine magnetic resonance imaging methods are limited by their intermittent measurements, requirements skilled personnel, indirect interfaces, and/or tethered connections. This paper reports a wireless, miniaturized, minimally invasive near-infrared spectroscopic system designed uninterrupted local-tissue oxygenation. A bioresorbable barbed structure anchors the probe stably at implantation sites time period matched to clinical need, with ability facile removal afterward. The connects skin-interfaced electronic module wireless access essential physiological parameters, local oxygenation, pulse heart rate. In vitro tests in vivo studies porcine flap kidney models demonstrate continuously measure oxygenation high accuracy sensitivity.

Language: Английский

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Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review

Sensors, Journal Year: 2023, Volume and Issue: 23(24), P. 9842 - 9842

Published: Dec. 15, 2023

Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical challenges due to their invasive nature and limited treatment options. The current therapeutic landscape for gliomas is constrained by "one-size-fits-all" paradigm, significantly restricting efficacy. Despite the implementation multimodal strategies, survival rates remain disheartening. conventional approach, involving surgical resection, radiation, chemotherapy, grapples with substantial limitations, particularly in addressing gliomas. Conventional diagnostic tools, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission (PET), play pivotal roles outlining tumor characteristics. However, they face such as poor biological specificity distinguishing active regions. ongoing development tools approaches represents multifaceted promising frontier battle against this challenging tumor. aim comprehensive review address recent advances These innovations minimize invasiveness while enabling precise, targeting localized Researchers are actively developing new colorimetric techniques, electrochemical biosensors, optical coherence tomography, reflectometric interference spectroscopy, surface-enhanced Raman biosensors. regulate progression develop precise methods Recent technological advancements, coupled bioelectronic sensors, open avenues modalities, minimizing unprecedented precision. next generation strategies holds potential precision medicine, aiding early detection effective management solid tumors. offer promise adopting medicine methodologies, disease detection, improving management. This comprehensively recognizes critical role pioneering interventions, holding significant revolutionize therapeutics.

Language: Английский

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A Miniaturized, Battery‐Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(28)

Published: July 6, 2023

Diabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation mortality, highlighting critical need for their early detection. Recent demonstrations wearable sensors enable real-time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery-free monitor measures lactate in seamlessly integrates bandages conformal attachment bed is introduced. Lactate selected due its multifaceted role initiating healing. Studies healthy diabetic mice reveal distinct profiles normal impaired healing A mathematical model based sensor data predicts closure rate within first 3 days post-injury ≈76% accuracy, which increases ≈83% when pH included. These studies underscore significance monitoring biomarkers during inflammation phase, can offer several benefits, including short-term use monitors easy removal, resulting lower risks injury infection at site. Improvements prediction accuracy be achieved by designing models build multiple parameters such as pro-inflammatory metabolic markers. Achieving this goal will require multi-analyte monitors.

Language: Английский

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