Multimodal Technologies for Closed‐Loop Neural Modulation and Sensing DOI
Lizhu Li,

Bozhen Zhang,

Wenxin Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 19, 2024

Existing methods for studying neural circuits and treating neurological disorders are typically based on physical chemical cues to manipulate record activities. These approaches often involve predefined, rigid, unchangeable signal patterns, which cannot be adjusted in real time according the patient's condition or With continuous development of interfaces, conducting vivo research adaptive modifiable treatments diseases is now possible. In this review, current potential integration various modalities achieve precise, closed-loop modulation, sensing systems summarized. Advanced materials, devices, that generate detect electrical, magnetic, optical, acoustic, signals highlighted utilized interact with cells, tissues, networks interrogation. Further, significance developing techniques diagnostics treatment such as epilepsy, depression, rehabilitation spinal cord injury patients, exploration brain circuit functionality elaborated.

Language: Английский

Incorporating Wireless Strategies to Wearable Devices Enabled by a Photocurable Hydrogel for Monitoring Pressure Information DOI

Yunjian Guo,

Feifei Yin, Yang Li

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(29)

Published: March 31, 2023

Advances in emerging technologies for wireless collection and the timely analysis of various information captured by wearable devices are growing interest. Herein, a crosslinked ionic hydrogel prepared facile photocuring process is proposed, which allows to be further incorporated into two integrated systems pressure monitoring applications. The device exhibits simplified structure effectively sharing functional layers, rather than conventional separate combinations, offering salient performance iontronic sensing electrochromic properties simultaneously quantify visualize pressure. developed smart patch system demonstrated monitor physiological signals real-time utilizing user interface remote portable equipment with Bluetooth protocol on-site displays. Moreover, passive based on magnetic coupling effect designed, can operate free from battery acquire multiple information. It envisioned that strategies would hold enormous potential flexible electronics, versatile platforms, on-body networks.

Language: Английский

Citations

103

Bridging live-cell imaging and next-generation cancer treatment DOI
María Alieva, Amber K. L. Wezenaar, Ellen J. Wehrens

et al.

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(11), P. 731 - 745

Published: Sept. 13, 2023

Language: Английский

Citations

38

Illuminating the Brain: Advances and Perspectives in Optoelectronics for Neural Activity Monitoring and Modulation DOI Creative Commons
Shumao Xu,

Marzia Momin,

Salahuddin Ahmed

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(42)

Published: Sept. 19, 2023

Abstract Optogenetic modulation of brain neural activity that combines optical and electrical modes in a unitary system has recently gained robust momentum. Controlling illumination spatial coverage, designing light‐activated modulators, developing wireless light delivery data transmission are crucial for maximizing the use neuromodulation. To this end, biocompatible electrodes with enhanced optoelectrical performance, device integration multiplexed addressing, transmission, multimodal operation soft systems have been developed. This review provides an outlook uniformly illuminating large areas while spatiotemporally imaging responses upon stimulation little artifacts. Representative concepts important breakthroughs, such as head‐mounted illumination, multiple implanted fibers, micro‐light‐delivery devices, discussed. Examples techniques incorporate electrophysiological monitoring presented. Challenges perspectives posed further research efforts toward high‐density interface modulation, potential nonpharmacological neurological disease treatments stimulation.

Language: Английский

Citations

27

A wireless battery-free eye modulation patch for high myopia therapy DOI Creative Commons
Tianyan Zhong,

Hangjin Yi,

Jiacheng Gou

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 26, 2024

Abstract The proper axial length of the eye is crucial for achieving emmetropia. In this study, we present a wireless battery-free modulation patch designed to correct high myopia and prevent relapse. consists piezoelectric transducers, an electrochemical micro-actuator, drug microneedle array, μ-LEDs, flexible circuit, biocompatible encapsulation. system can be wirelessly powered controlled using external ultrasound. micro-actuator plays key role in precisely shortening by driving posterior sclera inward. This ensures accurate scene imaging on retina eye. array delivers riboflavin sclera, μ-LEDs’ blue light induces collagen cross-linking, reinforcing strength. vivo experiments demonstrate that successfully reduces rabbit eye’s ~1217 μm increases strength 387%. operates effectively within body without need batteries. Here, show offers promising avenue clinically treating myopia.

Language: Английский

Citations

14

Remote optogenetic control of the enteric nervous system and brain-gut axis in freely-behaving mice enabled by a wireless, battery-free optoelectronic device DOI
Andrew I. Efimov, Timothy J. Hibberd, Yue Wang

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 258, P. 116298 - 116298

Published: April 17, 2024

Language: Английский

Citations

11

Control of polymers’ amorphous-crystalline transition enables miniaturization and multifunctional integration for hydrogel bioelectronics DOI Creative Commons

Sizhe Huang,

Xinyue Liu, Shaoting Lin

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 25, 2024

Abstract Soft bioelectronic devices exhibit motion-adaptive properties for neural interfaces to investigate complex circuits. Here, we develop a fabrication approach through the control of metamorphic polymers’ amorphous-crystalline transition miniaturize and integrate multiple components into hydrogel bioelectronics. We attain an about 80% diameter reduction in chemically cross-linked polyvinyl alcohol fibers fully hydrated state. This strategy allows regulation properties, including refractive index (1.37-1.40 at 480 nm), light transmission (>96%), stretchability (139-169%), bending stiffness (4.6 ± 1.4 N/m), elastic modulus (2.8-9.3 MPa). To exploit applications, apply step-index optical probes mouse ventral tegmental area, coupled with fiber photometry recordings social behavioral assays. Additionally, fabricate carbon nanotubes-PVA microelectrodes by incorporating conductive nanomaterials spontaneous activities recording. enable simultaneous optogenetic stimulation electrophysiological light-triggered Channelrhodopsin-2 transgenic mice.

Language: Английский

Citations

10

Shape-deformable Micro-LEDs for advanced displays and healthcare DOI Open Access
Shenghan Zou, Yuzhi Li, Zheng Gong

et al.

Soft Science, Journal Year: 2024, Volume and Issue: 4(2)

Published: May 17, 2024

Recently, flexible/stretchable micro-scale light-emitting diodes (LEDs), with dimensions significantly smaller than conventional used for illuminations, have emerged promising applications in areas such as deformable displays, wearable devices healthcare, etc . For applications, these must some unusual features that common inorganic LEDs do not intrinsically own, including conformability, biocompatibility, mechanical flexibility, This Perspective focuses on summarizing the most recent progress developing flexible emitters based semiconductors, followed by reviewing their potential applications. Finally, major challenges and future research directions of are presented.

Language: Английский

Citations

9

Modular brain-machine interface for neurorecording, neurostimulation, and drug delivery DOI

Tian‐Lu Sheng,

Lingyi Zheng,

Jingwei Li

et al.

Device, Journal Year: 2025, Volume and Issue: unknown, P. 100687 - 100687

Published: Jan. 1, 2025

Language: Английский

Citations

1

Power-integrated, wireless neural recording systems on the cranium using a direct printing method for deep-brain analysis DOI Creative Commons
Yong Won Kwon, David B. Ahn, Young‐Geun Park

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(14)

Published: April 3, 2024

Conventional power-integrated wireless neural recording devices suffer from bulky, rigid batteries in head-mounted configurations, hindering the precise interpretation of subject's natural behaviors. These power sources also pose risks material leakage and overheating. We present direct printing a system that seamlessly conforms to cranium. A quasi-solid-state Zn-ion microbattery was 3D-printed as built-in source geometrically synchronized shape mouse skull. Soft deep-brain probes, interconnections, auxiliary electronics were printed using liquid metals on cranium with high resolutions. In vivo studies mice demonstrated reliability biocompatibility this system, enabling monitoring activities across extensive brain regions without notable heat generation. This all-printed interface revolutionizes research, providing bio-conformable, customizable configurations for improved data quality naturalistic experimentation.

Language: Английский

Citations

8

Beyond Flexible: Unveiling the Next Era of Flexible Electronic Systems DOI Creative Commons
Min Sung Kim, Amani Saleh Almuslem, Wedyan Babatain

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 11, 2024

Abstract Flexible electronics are integral in numerous domains such as wearables, healthcare, physiological monitoring, human–machine interface, and environmental sensing, owing to their inherent flexibility, stretchability, lightweight construction, low profile. These systems seamlessly conform curvilinear surfaces, including skin, organs, plants, robots, marine species, facilitating optimal contact. This capability enables flexible electronic enhance or even supplant the utilization of cumbersome instrumentation across a broad range monitoring actuation tasks. Consequently, significant progress has been realized development systems. study begins by examining key components standalone systems–sensors, front‐end circuitry, data management, power management actuators. The next section explores different integration strategies for well recent advancements. hybrid electronics, which is currently most widely used strategy, first reviewed assess characteristics applications. Subsequently, transformational achieves compact high‐density system leveraging heterogeneous bare‐die components, highlighted era Finally, concludes suggesting future research directions outlining critical considerations challenges developing miniaturizing fully integrated

Language: Английский

Citations

6