Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function in mice

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: April 15, 2023

Reduced reward interest/learning and reward-to-effort valuation are distinct, common symptoms in neuropsychiatric disorders for which chronic stress is a major aetiological factor. Glutamate neurons basal amygdala (BA) project to various regions including nucleus accumbens (NAc). The BA-NAc neural pathway activated by aversion, with many being monovalent. In adult male mice, social (CSS) leads reduced discriminative learning (DRL) associated decreased activity, (REV) associated, contrast, increased activity. Chronic tetanus toxin inhibition replicates the CSS-DRL effect causes mild REV reduction, whilst DREADDs activation CSS on without affecting DRL. This study provides evidence that disruption of processing involves pathway; bi-directional effects implicate opposite activity changes (learning) aversion (effort) following stress.

Language: Английский

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Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 9, 2023

Abstract The auditory striatum, a sensory portion of the dorsal plays an essential role in learning and memory. In contrast to its roles underlying mechanisms operant conditioning, however, little is known about contribution classical fear conditioning. Here, we reveal function striatum auditory-conditioned We find that optogenetically inhibiting striatal neurons impairs memory formation, which mediated through striatal-amygdala pathway. Using calcium imaging behaving mice, neuronal responses conditioned tones potentiate across acquisition expression. Furthermore, nigrostriatal dopaminergic projections important modulating conditioning-induced potentiation. Together, these findings demonstrate existence nigro-striatal-amygdala circuit for formation

Language: Английский

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Engagement of basal amygdala‐nucleus accumbens glutamate neurons in the processing of rewarding or aversive social stimuli

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 59(5), P. 996 - 1015

Published: Feb. 7, 2024

Abstract Basal amygdala (BA) neurons projecting to nucleus accumbens (NAc) core/shell are primarily glutamatergic and integral the circuitry of emotional processing. Several recent mouse studies have addressed whether in this population(s) respond reward, aversion or both valences. The focus has been on processing physical stimuli, here, we extend salient social stimuli. In male mice, an iterative study was conducted into engagement BA‐NAc response estrous female (social SR) and/or aggressive‐dominant aversion, SA). BL/6J SR SA activated c‐Fos expression a high similar number/density anteroposterior intermediate BA (int‐BA), whereas activation predominantly by posterior (post‐)BA. Fos‐TRAP2 compared with SR‐SR SA‐SA controls, exposure successive presentation SR‐SA SA‐SR, followed assessment tdTomato reporter expression, demonstrated that many int‐BA‐NAc were only one SA; these SR/SA monovalent number present magnocellular parvocellular int‐BA subregions. freely moving mice exposed SR, bulk GCaMP6 fibre photometry provided confirmatory vivo evidence for during sexual interactions. Therefore, populations glutamate engaged rewarding aversive stimuli topographic valence‐specific manner; novel is important overall understanding roles pathway socio‐emotional

Language: Английский

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Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders

Frontiers in Systems Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Oct. 5, 2022

Amygdaloid circuits are involved in a variety of emotional and motivation-related behaviors impacted by stress. The amygdala expresses several neuromodulatory systems, including opioid peptides their receptors. Dynorphin (Dyn)/kappa receptor (KOR) system has been implicated the processing stress-related information is expressed brain areas stress motivation. Dysregulation Dyn/KOR also various neuropsychiatric disorders. However, there limited about role regulating circuitry. Here, we review literature on (1) basic anatomy amygdala, (2) functional regulation synaptic transmission system, (3) anatomical architecture function (4) amygdala-dependent (5) future directions for field. Future work investigating how shapes wide range amygdala-related will be required to increase our understanding underlying circuitry modulation system. We anticipate that continued focus elucidate novel ways target treat

Language: Английский

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Molecular diversity and functional dynamics in the central amygdala

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Feb. 14, 2024

The central amygdala (CeA) is crucial in integrating sensory and associative information to mediate adaptive responses emotional stimuli. Recent advances genetic techniques like optogenetics chemogenetics have deepened our understanding of distinct neuronal populations within the CeA, particularly those involved fear learning memory consolidation. However, challenges remain due overlapping markers complicating neuron identification. Furthermore, a comprehensive molecularly defined cell types their projection patterns, which are essential for elucidating functional roles, still developing. advancements transcriptomics starting bridge these gaps, offering new insights into dynamics CeA neurons. In this review, we provide an overview expanding research, encompassing recent developments current trends. We also discuss how novel transcriptomic approaches redefining setting stage studies.

Language: Английский

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