Current Biology,
Journal Year:
2022,
Volume and Issue:
32(16), P. 3443 - 3459.e8
Published: July 8, 2022
The
wiring
architecture
of
neuronal
networks
is
assumed
to
be
a
strong
determinant
their
dynamical
computations.
An
ongoing
effort
in
neuroscience
therefore
generate
comprehensive
synapse-resolution
connectomes
alongside
brain-wide
activity
maps.
However,
the
structure-function
relationship,
i.e.,
how
anatomical
connectome
and
dynamics
relate
each
other
on
global
scale,
remains
unsolved.
Systematically,
comparing
graph
features
C.
elegans
with
correlations
nervous
system-wide
dynamics,
we
found
that
few
local
connectivity
motifs
mostly
non-local
such
as
triplet
input
similarities
can
predict
functional
relationships
between
neurons.
Surprisingly,
quantities
connection
strength
amount
common
inputs
do
not
improve
these
predictions,
suggesting
network's
topology
sufficient.
We
demonstrate
hub
neurons
are
key
relevant
features.
Consistently,
inhibition
multiple
specifically
disrupts
correlations.
Thus,
propose
set
provide
an
substrate
for
brain
dynamics.
Nature,
Journal Year:
2023,
Volume and Issue:
617(7960), P. 360 - 368
Published: May 3, 2023
Abstract
Mapping
behavioural
actions
to
neural
activity
is
a
fundamental
goal
of
neuroscience.
As
our
ability
record
large
and
data
increases,
there
growing
interest
in
modelling
dynamics
during
adaptive
behaviours
probe
representations
1–3
.
In
particular,
although
latent
embeddings
can
reveal
underlying
correlates
behaviour,
we
lack
nonlinear
techniques
that
explicitly
flexibly
leverage
joint
behaviour
uncover
3–5
Here,
fill
this
gap
with
new
encoding
method,
CEBRA,
jointly
uses
(supervised)
hypothesis-
or
(self-supervised)
discovery-driven
manner
produce
both
consistent
high-performance
spaces.
We
show
consistency
be
used
as
metric
for
uncovering
meaningful
differences,
the
inferred
latents
decoding.
validate
its
accuracy
demonstrate
tool’s
utility
calcium
electrophysiology
datasets,
across
sensory
motor
tasks
simple
complex
species.
It
allows
single-
multi-session
datasets
hypothesis
testing
label
free.
Lastly,
CEBRA
mapping
space,
kinematic
features,
production
spaces
two-photon
Neuropixels
data,
provide
rapid,
high-accuracy
decoding
natural
videos
from
visual
cortex.
Cell,
Journal Year:
2023,
Volume and Issue:
186(19), P. 4134 - 4151.e31
Published: Aug. 21, 2023
Changes
in
an
animal's
behavior
and
internal
state
are
accompanied
by
widespread
changes
activity
across
its
brain.
However,
how
neurons
the
brain
encode
this
is
impacted
poorly
understood.
We
recorded
brain-wide
diverse
motor
programs
of
freely
moving
C.
elegans
built
probabilistic
models
that
explain
each
neuron
encodes
quantitative
behavioral
features.
By
determining
identities
neurons,
we
created
atlas
defined
classes
connectome
behavior.
Many
have
conjunctive
representations
multiple
behaviors.
Moreover,
although
many
current
actions,
others
integrate
recent
actions.
behavior,
identify
these
flexible
nodes
connectome.
Our
results
provide
a
global
map
cell
types
