Spatial and temporal heterogeneity in the lineage progression of fine oligodendrocyte subtypes

BMC Biology, Journal Year: 2022, Volume and Issue: 20(1)

Published: May 25, 2022

Oligodendrocytes are glial cells that support and insulate axons in the central nervous system through production of myelin. arise throughout embryonic early postnatal development from oligodendrocyte precursor (OPCs), recent work demonstrated they a transcriptional heterogeneous cell population, but regional functional implications this heterogeneity less clear. Here, we apply situ sequencing (ISS) to simultaneously probe expression 124 marker genes distinct populations, providing comprehensive maps corpus callosum, cingulate, motor, somatosensory cortex brain, as well gray matter (GM) white (WM) regions spinal cord, at (P10), juvenile (P20), young adult (P60) stages. We systematically compare abundances these populations investigate neighboring preference populations.We observed lineage progression is more advanced cord compared corroborating with previous studies. found myelination still ongoing callosum while it was cortex. Interestingly, also lateral-to-medial gradient cortex, which could be linked arealization, deep-to-superficial mature oligodendrocytes preferentially accumulating deeper layers The ISS experiments exposed differences population dynamics over time between GM WM brain indicating within WM, preferences some oligodendroglia altered CNS.Overall, our reveal spatial uncover timing differentiation myelination, relevant further oligodendroglia, especially context injury or disease.

Language: Английский

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Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(10), P. 1739 - 1750

Published: Sept. 11, 2023

Language: Английский

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A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System

Neuroscience Bulletin, Journal Year: 2024, Volume and Issue: 40(10), P. 1573 - 1589

Published: July 23, 2024

Language: Английский

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Oligodendroglia heterogeneity in the human central nervous system

Acta Neuropathologica, Journal Year: 2021, Volume and Issue: 143(2), P. 143 - 157

Published: Dec. 3, 2021

Abstract It is the centenary of discovery oligodendrocytes and we are increasingly aware their importance in functioning brain development, adult learning, normal ageing disease across life course, even those diseases classically thought as neuronal. This has sparked more interest oligodendroglia for potential therapeutics many neurodegenerative/neurodevelopmental due to tractable nature a renewable cell central nervous system. However, not all same. Even from first description, differences morphology were described between cells. With advancing techniques describe these human tissue, complexity being discovered, indicating apparent functional which may be critical determining vulnerability response disease, targeting therapeutics. timely review progress have made discovering understanding oligodendroglial heterogeneity health neuropathology.

Language: Английский

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Glial regulation of critical period plasticity

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Nov. 16, 2023

Animal behavior, from simple to complex, is dependent on the faithful wiring of neurons into functional neural circuits. Neural circuits undergo dramatic experience-dependent remodeling during brief developmental windows called critical periods. Environmental experience periods plasticity produces sustained changes circuit function and behavior. Precocious period closure linked autism spectrum disorders, whereas extended synaptic thought underlie dysfunction in schizophrenia. Thus, resolving mechanisms that instruct timing important our understanding neurodevelopmental disorders. Control modulated by neuron-intrinsic cues, yet recent data suggest some determinants are derived neighboring glial cells (astrocytes, microglia, oligodendrocytes). As glia make up 50% human brain, how these diverse communicate with each other sculpt plasticity, especially specialized periods, essential fundamental development maintenance.

Language: Английский

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Features, Fates, and Functions of Oligodendrocyte Precursor Cells

Cold Spring Harbor Perspectives in Biology, Journal Year: 2023, Volume and Issue: 16(3), P. a041425 - a041425

Published: Dec. 5, 2023

Robert A. Hill1, Akiko Nishiyama2 and Ethan G. Hughes3 1Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA 2Department Physiology Neurobiology, University Connecticut, Storrs, Connecticut 06269, 3Department Cell Developmental Biology, Colorado School Medicine, Aurora, 80045, Correspondence: robert.hill{at}dartmouth.edu

Language: Английский

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Glial modulation of synapse development and plasticity: oligodendrocyte precursor cells as a new player in the synaptic quintet

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 27, 2024

Synaptic communication is an important process in the central nervous system that allows for rapid and spatially specified transfer of signals. Neurons receive various synaptic inputs generate action potentials required information transfer, these can be excitatory or inhibitory, which collectively determines output. Non-neuronal cells (glial cells) have been identified as crucial participants influencing neuronal activity transmission, with astrocytes forming tripartite synapses microglia pruning synapses. While it has known oligodendrocyte precursor (OPCs) inputs, whether they also influence transmission remained unknown two decades. Recent findings indicate OPCs, too, modulate In this review, we discuss roles different glial cell types at synapses, including recently discovered involvement OPCs synapse refinement, overlapping played by multiple types.

Language: Английский

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A molecularly defined subpopulation of oligodendrocyte precursor cells controls the generation of myelinating oligodendrocytes during postnatal development

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(7), P. e3002655 - e3002655

Published: July 10, 2024

Oligodendrocyte precursor cells (OPCs) are a class of glial that uniformly tiles the entire central nervous system (CNS). They play several key functions across brain including generation oligodendrocytes and control myelination. Whether functional diversity OPCs is result genetically defined subpopulations or their regulation by external factors has not been definitely established. We discovered subpopulation found expression C1ql1 , gene previously described for its synaptic function in neurons. This starts to appear during first postnatal week mouse cortex. Ablation -expressing leads massive lack myelination many regions. deficit cannot be rescued, even though some escape Sox10 -driven ablation end up partially compensating OPC loss adult. Therefore, molecular marker functionally non-redundant OPCs, which controls myelinating oligodendrocytes.

Language: Английский

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Oligodendrocytes Prune Axons Containing α-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?

Biomolecules, Journal Year: 2023, Volume and Issue: 13(2), P. 269 - 269

Published: Feb. 1, 2023

α-Synucleinopathies are spreading neurodegenerative disorders characterized by the intracellular accumulation of insoluble aggregates populated α-Synuclein (α-Syn) fibrils. In Parkinson’s disease (PD) and dementia with Lewy bodies, intraneuronal α-Syn referred to as bodies in somata neurites neuronal processes. multiple system atrophy (MSA) also found within mature oligodendrocytes (OLs) where they form Glial Cytoplasmic Inclusions (GCIs). However, origin GCIs remains enigmatic: (i) OLs do not express α-Syn, precluding seeding buildup inclusions (ii) artificial overexpression transgenic mice results a burden soluble phosphorylated but fails contrast, mass spectrometry fibrillar from MSA patients points proteins intimately associated fibrils GCIs. This suggests that preassembled neurons only secondarily incorporated into OLs. Interestingly, we recently isolated synthetic human fibril strain (1B fibrils) capable type inclusion observed early specifically during MSA. Our goal was thus investigate whether pathology seeded 1B could eventually be transmitted vivo. After confirming did detectable levels adult mouse brain, series received unilateral intra-striatal injections The resulting visualized using phospho-S129 immunoreactivity (pSyn). We even though were injected unilaterally, many pSyn-positive somas present layer V contralateral perirhinal cortex after 6 weeks. suggested fast retrograde spread along axons crossing cortico-striatal neurons. scrutinized posterior limb anterior commissure, i.e., myelinated interhemispheric tract containing these neurons: indeed numerous linear Neurites oriented parallel commissural axis, corresponding axonal segments filled aggregated no obvious signs OL at this stage. months however, longer fragmented, curled up, sometimes squeezed in-between two consecutive interfascicular strands, or engulfed inside perikarya, forming conclude can rapidly induce an typical mice, which appearance pruning diseased α-Syn.

Language: Английский

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Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy

Cells, Journal Year: 2023, Volume and Issue: 12(5), P. 739 - 739

Published: Feb. 25, 2023

Multiple system atrophy (MSA) is a debilitating movement disorder with unknown etiology. Patients present characteristic parkinsonism and/or cerebellar dysfunction in the clinical phase, resulting from progressive deterioration nigrostriatal and olivopontocerebellar regions. MSA patients have prodromal phase subsequent to insidious onset of neuropathology. Therefore, understanding early pathological events important determining pathogenesis, which will assist developing disease-modifying therapy. Although definite diagnosis relies on positive post-mortem finding oligodendroglial inclusions composed α-synuclein, only recently has been verified as an oligodendrogliopathy secondary neuronal degeneration. We review up-to-date knowledge human oligodendrocyte lineage cells their association discuss postulated mechanisms how develops, progenitor potential origins toxic seeds possible networks through induces loss. Our insights shed new light research directions for future studies.

Language: Английский

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