Survey of hippocampal responses to sound in naïve mice reveals widespread activation by broadband noise onsets DOI Creative Commons
James H. Bigelow,

Toshiaki SUZUKI,

Yulang Wu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

Abstract Recent studies suggest some hippocampal (HC) neurons respond to passively presented sounds in naïve subjects, but the specificity and prevalence of these responses remain unclear. We used Neuropixels probes record unit activity HC auditory cortex (ACtx) awake, untrained mice during presentation diverse sound stimuli. A subset exhibited reliable, short-latency passive sounds, including tones broadband noise. units showed evidence tuning for tone frequency not spectrotemporal features continuous dynamic moving ripples. Across types, overwhelmingly occurred at stimulus onset; they quickly adapted did offset. Among all tested, noise was by far most effective driving activity, with response scaling increasing spectral bandwidth density. Responses were also more common than visual flash Sound-evoked face movements, quantified total facial motion energy (FME), correlated population-level many individual responded regardless movement, indicating both motor-related inputs. These results show that abrupt, acoustic events are sufficient activate absence learning or behavioral engagement. This suggests a possible role detecting salient environmental changes supports idea inputs contribute directly function. Given emerging links between hearing loss dementia, findings highlight potential pathway which deafferentation could impact cognitive health.

Language: Английский

Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities in mice DOI
Kameron K. Clayton, Kamryn S. Stecyk,

Anna Guo

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(8), P. 1605 - 1620.e5

Published: March 15, 2024

Language: Английский

Citations

19
Triple dissociation of visual, auditory and motor processing in mouse primary visual cortex DOI
Matthijs N. Oude Lohuis, Pietro Marchesi, Umberto Olcese

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(4), P. 758 - 771

Published: Feb. 2, 2024

Language: Английский

Citations

18
Contribution of behavioural variability to representational drift DOI Creative Commons
Sadra Sadeh, Claudia Clopath

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Aug. 30, 2022

Neuronal responses to similar stimuli change dynamically over time, raising the question of how internal representations can provide a stable substrate for neural coding. Recent work has suggested large degree drift in even sensory cortices, which are believed store external world. While these is mostly characterized relation stimuli, behavioural state animal (for instance, level arousal) also known strongly modulate activity. We therefore asked variability such modulatory mechanisms contribute representational changes. analysed large-scale recording activity from Allen Brain Observatory, was used before document mouse visual cortex. found that, within datasets, significantly contributes This effect broadcasted across various cortical areas mouse, including primary cortex, higher order areas, and regions not primarily linked vision like hippocampus. Our computational modelling suggests that results consistent with independent modulation by behaviour slower timescales. Importantly, our analysis reliable but variable be misinterpreted as if neuronal only stimulus space marginalized parameters.

Language: Английский

Citations

54
Mouse frontal cortex mediates additive multisensory decisions DOI Creative Commons
Philip Coen, Timothy Sit, Miles Wells

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(15), P. 2432 - 2447.e13

Published: June 8, 2023

The brain can combine auditory and visual information to localize objects. However, the cortical substrates underlying audiovisual integration remain uncertain. Here, we show that mouse frontal cortex combines evidence; this combination is additive, mirroring behavior; it evolves with learning. We trained mice in an localization task. Inactivating impaired responses either sensory modality, while inactivating or parietal affected only stimuli. Recordings from >14,000 neurons indicated after task learning, activity anterior part of area MOs (secondary motor cortex) additively encodes signals, consistent mice's behavioral strategy. An accumulator model applied these representations reproduced observed choices reaction times. These results suggest adapts through learning evidence across cortices, providing a signal transformed into binary decision by downstream accumulator.

Language: Английский

Citations

42
Activity in primate visual cortex is minimally driven by spontaneous movements DOI Creative Commons
Bharath Chandra Talluri, In‐Cheol Kang,

Adam Lazere

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(11), P. 1953 - 1959

Published: Oct. 12, 2023

Organisms process sensory information in the context of their own moving bodies, an idea referred to as embodiment. This is important for developmental neuroscience, robotics and systems neuroscience. The mechanisms supporting embodiment are unknown, but a manifestation could be observation mice brain-wide neuromodulation, including primary visual cortex, driven by task-irrelevant spontaneous body movements. We tested this hypothesis macaque monkeys (Macaca mulatta), primate model human vision, simultaneously recording cortex activity facial also sought direct comparison using analogous approach those used mouse studies. Here we found that (V1, V2 V3/V3A) was associated with animals' movements, modulation largely explained impact movements on retinal image, is, changes input. These results indicate primates minimally may reflect species-specific sensorimotor strategies.

Language: Английский

Citations

39
The spatial and temporal structure of neural activity across the fly brain DOI Creative Commons
Evan Schaffer, Neeli Mishra, Matthew R Whiteway

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 11, 2023

What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume brain adult Drosophila with high spatiotemporal resolution while flies engaged variety spontaneous behaviors. This revealed neural representations behavior on multiple scales. The activity most neurons correlated (or anticorrelated) running flailing over timescales that ranged from seconds minute. Grooming elicited weaker global response. Significant residual not directly was dimensional reflected small clusters spatially organized may correspond genetically defined cell types. These participate dynamics, indicating reflects combination local broadly distributed components. suggests microcircuits highly specified functions provided knowledge larger context which they operate.

Language: Английский

Citations

27
Top-down input modulates visual context processing through an interneuron-specific circuit DOI Creative Commons

Georgia Bastos,

Jacob T. Holmes,

Jordan M. Ross

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(9), P. 113133 - 113133

Published: Sept. 1, 2023

Visual stimuli that deviate from the current context elicit augmented responses in primary visual cortex (V1). These heightened responses, known as "deviance detection," require local inhibition V1 and top-down input anterior cingulate area (ACa). Here, we investigated mechanisms by which ACa interact to support deviance detection. Local field potential recordings mice during an oddball paradigm showed ACa-V1 synchrony peaks theta/alpha band (≈10 Hz). Two-photon imaging revealed mainly pyramidal neurons exhibited detection, while contextually redundant increased vasoactive intestinal peptide (VIP)-positive interneuron (VIP) activity decreased somatostatin-positive (SST) activity. Optogenetic drive of inputs at 10 Hz activated V1-VIPs but inhibited V1-SSTs, mirroring dynamics present paradigm. Chemogenetic disrupted Aca-V1 detection V1. results outline temporal interneuron-specific modulation processing.

Language: Английский

Citations

25
Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal DOI Creative Commons
Diego E. Hernández, Andrei Ciuparu, Pedro Garcia da Silva

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 22, 2025

While animals readily adjust their behavior to adapt relevant changes in the environment, neural pathways enabling these remain largely unknown. Here, using multiphoton imaging, we investigate whether feedback from piriform cortex olfactory bulb supports such behavioral flexibility. To this end, engage head-fixed male mice a multimodal rule-reversal task guided by and auditory cues. Both odor and, surprisingly, sound cues trigger responses cortical bulbar axons which precede report. Responses same sensory cue are strongly modulated upon stimulus-reward contingency (rule-reversals). The re-shaping of individual bouton occurs within seconds events is correlated with behavior. Optogenetic perturbation disrupts performance. Our results indicate that piriform-to-olfactory carry stimulus identity reward signals rapidly re-formatted according context. Hernandez-Trejo, Ciuparu, Garcia da Silva et al. report mouse carries signals, seconds,

Language: Английский

Citations

1
Ongoing movement controls sensory integration in the dorsolateral striatum DOI Creative Commons
Roberto de la Torre‐Martínez, Maya Ketzef, Gilad Silberberg

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 22, 2023

Abstract The dorsolateral striatum (DLS) receives excitatory inputs from both sensory and motor cortical regions. In the neocortex, responses are affected by activity, however, it is not known whether such sensorimotor interactions occur in how they shaped dopamine. To determine impact of activity on striatal processing, we performed vivo whole-cell recordings DLS awake mice during presentation tactile stimuli. Striatal medium spiny neurons (MSNs) were activated whisker stimulation spontaneous whisking, their to deflection ongoing whisking attenuated. Dopamine depletion reduced representation direct-pathway MSNs, but those indirect-pathway. Furthermore, dopamine impaired discrimination between ipsilateral contralateral direct indirect pathway MSNs. Our results show that affects processes dopamine- cell type-dependent.

Language: Английский

Citations

20
Rastermap: a discovery method for neural population recordings DOI Creative Commons
Carsen Stringer, Lin Zhong, Atika Syeda

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 28, 2023

Abstract Neurophysiology has long progressed through exploratory experiments and chance discoveries. Anecdotes abound of researchers setting up while listening to spikes in real time observing a pattern consistent firing when certain stimuli or behaviors happened. With the advent large-scale recordings, such close observation data become harder because high-dimensional spaces are impenetrable our pattern-finding intuitions. To help ourselves find patterns neural data, lab been openly developing visualization framework known as “Rastermap” over past five years. Rastermap takes advantage new global optimization algorithm for sorting responses along one-dimensional manifold. Displayed raster plot, sorted neurons show variety activity patterns, which can be more easily identified interpreted. We first benchmark on realistic simulations with multiplexed cognitive variables. Then we demonstrate it recordings tens thousands from mouse visual sensorimotor cortex during spontaneous, stimulus-evoked task-evoked epochs, well whole-brain zebrafish widefield calcium imaging population rat hippocampus artificial networks. Finally, illustrate scenarios where similar algorithms cannot used effectively.

Language: Английский

Citations

19