Reply to: A curious concept of CNS clearance DOI
Nicholas P. Franks, William Wisden

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep DOI
Natalie Hauglund, Mie Andersen,

Klaudia Tokarska

et al.

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

22
Anything but small: Microarousals stand at the crossroad between noradrenaline signaling and key sleep functions DOI Creative Commons
Anita Lüthi, Maiken Nedergaard

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Continuous sleep restores the brain and body, whereas fragmented harms cognition health. Microarousals (MAs), brief (3- to 15-s-long) wake intrusions into sleep, are clinical markers for various disorders. Recent rodent studies show that MAs during healthy non-rapid eye movement (NREM) driven by infraslow fluctuations of noradrenaline (NA) in coordination with electrophysiological rhythms, vasomotor activity, cerebral blood volume, glymphatic flow. hence part dynamics, raising questions about their biological roles. We propose bolster NREM sleep's benefits associated NA fluctuations, according an inverted U-shaped curve. Weakened noradrenergic as may occur neurodegenerative diseases or aids, reduce MAs, exacerbated caused stress fragment collapse signaling. suggest crucial restorative plasticity-promoting functions advance our insight normal pathological arousal dynamics from sleep.

Language: Английский

Citations

5
New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases DOI Creative Commons
Yujie Sun,

Qiankun Lv,

Junyi Liu

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 205, P. 106791 - 106791

Published: Jan. 6, 2025

Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial (ISF), facilitates movement metabolic substances within brain, serving functions akin to those peripheral lymphatic system. This emerging waste clearance mechanism offers a novel perspective on removal pathological in ND. article elucidates recent discoveries regarding system updates relevant concepts model. It discusses potential roles ND, including Alzheimer's disease (AD), Parkinson's (PD), multiple atrophy (MSA), proposes as therapeutic target for these conditions.

Language: Английский

Citations

2
Melatonin: A potential nighttime guardian against Alzheimer’s DOI Creative Commons
Z Zhang, Pei Xue, Barbara B. Bendlin

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 11, 2024

In the context of escalating global health challenge posed by Alzheimer's disease (AD), this comprehensive review considers potential melatonin in both preventive and therapeutic capacities. As a naturally occurring hormone robust antioxidant, accumulating evidence suggests is compelling candidate to consider AD-related pathologies. The several mechanisms, including effects on amyloid-beta pathologic tau burden, antioxidant defense, immune modulation, regulation circadian rhythms. Despite its promise, gaps need be addressed prior clinical translation. These include conducting additional randomized trials patients with or at risk for AD dementia, determining optimal dosage timing, further side effects, particularly long-term use. This consolidates existing knowledge, identifies gaps, directions future research better understand neuroprotection mitigation within landscape AD.

Language: Английский

Citations

11
Glymphatic clearance is enhanced during sleep DOI Open Access

Erik Kroesbergen,

Laurence V. Riesselmann,

Ryszard S. Gomolka

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

We here revisited the concept that glymphatic clearance is enhanced by sleep and anesthesia. Utilizing dynamic magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), fluorescent fiber photometry, we report brain both anesthesia, sharply suppressed wakefulness. Another key finding was less tracer enters brains of awake animals across different states can only be compared after adjusting for injected dose.

Language: Английский

Citations

10
Perivascular brain clearance as a therapeutic target in cerebral amyloid angiopathy and Alzheimer's disease DOI Creative Commons
Orla Bonnar, Beth Eyre, Susanne J. van Veluw

et al.

Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. e00535 - e00535

Published: Jan. 1, 2025

Language: Английский

Citations

1
A curious concept of CNS clearance DOI
Virginia Plá,

Erik Kroesbergen,

Saiyue Deng

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

1
Long-wavelength traveling waves of vasomotion modulate the perfusion of cortex DOI
Thomas Broggini,

J.C. Duckworth,

Xiang Ji

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(14), P. 2349 - 2367.e8

Published: May 22, 2024

Language: Английский

Citations

7
Advances in sleep research in 2024 DOI
Yves Dauvilliers

The Lancet Neurology, Journal Year: 2024, Volume and Issue: 24(1), P. 20 - 22

Published: Dec. 18, 2024

Language: Английский

Citations

5
SLEEP DISORDERS AND RISK OF ALZHEIMER'S DISEASE: A TWO-WAY ROAD DOI

Rafael Antônio Vicente Lacerda,

Janaína Aparecida Favero Desio, Camila Marciele Kammers

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102514 - 102514

Published: Sept. 1, 2024

Language: Английский

Citations

4