Vasopressin differentially modulates the excitability of rat olfactory bulb neuron subtypes DOI Creative Commons
Hajime Suyama, Gaia Bianchini, Michael Lukas

et al.

Frontiers in Neural Circuits, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 29, 2024

Vasopressin (VP) plays a crucial role in social memory even at the level of olfactory bulb (OB), where OB VP cells are activated during interactions. However, it remains unclear how modulates processing to enable enhanced discrimination very similar odors, e.g., rat body odors. Thus far, has been shown that reduces firing rates mitral (MCs) odor presentation vivo and decreases amplitudes nerve-evoked excitatory postsynaptic potentials (ON-evoked EPSPs) external tufted vitro . We performed whole-cell patch-clamp recordings population Ca 2+ imaging on acute slices. recorded ON-evoked EPSPs as well spontaneous inhibitory currents (IPSCs) from two types projection neurons: middle (mTCs) MCs. bath application reduced frequencies IPSCs mTCs but did not change those Therefore, we analyzed interneurons, i.e., periglomerular (PGCs) granule (GCs), search for origin increased inhibition mTCs. increase evoked either type interneurons. next two-photon glomerular layer superficial GC responses stronger ON stimulation than experiments should evoke action measured cells. observed influx juxtaglomerular somata. Thus, our findings indicate by neurons via strong input-mediated interneuron activity. This neural modulation could improve representation hence, better discriminability conspecific

Language: Английский

Regulating Itgb1 to Restore GnRH-Tanycyte Unit Function in PCOS-Related Hypothalamic Dysregulation DOI Creative Commons
Yu Wang, Xiaoyu Tong,

Yan Xiao

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Excessive gonadotropin-releasing hormone (GnRH) is considered to be an initiating factor in the etiology of polycystic ovary syndrome (PCOS). GnRH neuronal axons terminate at hypothalamic arcuate nucleus and median eminence, where tanycytes, specialized glial cells, have been proposed modulate secretion through plasticity. However, precise role “GnRH-tanycyte unit” during pathological state PCOS has not thoroughly explored. In this study, we demonstrated architecture distribution neurons tanycytes. PCOS-like mice, retracted tanycyte processes dysregulated GnRH-tanycyte unit may create environment conducive excessive subsequent reproductive endocrine dysfunction. Mechanistically, androgens impair neuroglial homeostasis by acting androgen receptor (AR) its downstream target integrin β1 (Itgb1), thereby suppressing FAK/TGF-βR1/Smad2 signaling pathway. Both selective deletion AR overexpression Itgb1 tanycytes counteracted detrimental effects androgens, alleviating Collectively, study highlights alterations mediated androgen/AR/Itgb1 provides a novel perspective for developing therapies disorders maintaining solid structures brain.

Language: Английский

Citations

0
Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome DOI Creative Commons
Yu Wang, Yicong Wang, Yuning Chen

et al.

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 5, 2025

Language: Английский

Citations

0
Sexual Failure Decreases Sweet Taste Perception in Male Drosophila via Dopaminergic Signaling DOI Open Access

Gaohang Wang,

Wei Qi, Rui Huang

et al.

Published: Feb. 18, 2025

Sweet taste perception, a critical aspect of the initiation feeding behavior, is primarily regulated by an animal’s internal metabolic state. However, non-metabolic factors, such as motivational and emotional states, can also influence peripheral sensory processing hence behavior. While mating experience known to induce changes, its broader impact on other innate behaviors remains largely uncharacterized. In this study, we demonstrated that failure male fruit flies suppressed sweet perception via dopamine signaling in specific neural circuitry. Upon repetitive courtship, exhibited sustained yet reversible decline measured proboscis extension reflex (PER) towards tastants well neuronal activity sweet-sensing Gr5a + neurons proboscis. Mechanistically, identified small group dopaminergic projecting subesophageal zone (SEZ) innervating with key modulator. Repetitive sexual decreased these turn Dop1R1 Dop2R receptors. Our findings revealed role for integrating reproductive appetitive processing, providing new insights into complex interactions between different brain’s reward systems regulating states.

Language: Английский

Citations

0
Sexual Failure Decreases Sweet Taste Perception in Male Drosophila via Dopaminergic Signaling DOI Open Access

Gaohang Wang,

Wei Qi, Rui Huang

et al.

Published: Feb. 18, 2025

Sweet taste perception, a critical aspect of the initiation feeding behavior, is primarily regulated by an animal’s internal metabolic state. However, non-metabolic factors, such as motivational and emotional states, can also influence peripheral sensory processing hence behavior. While mating experience known to induce changes, its broader impact on other innate behaviors remains largely uncharacterized. In this study, we demonstrated that failure male fruit flies suppressed sweet perception via dopamine signaling in specific neural circuitry. Upon repetitive courtship, exhibited sustained yet reversible decline measured proboscis extension reflex (PER) towards tastants well neuronal activity sweet-sensing Gr5a + neurons proboscis. Mechanistically, identified small group dopaminergic projecting subesophageal zone (SEZ) innervating with key modulator. Repetitive sexual decreased these turn Dop1R1 Dop2R receptors. Our findings revealed role for integrating reproductive appetitive processing, providing new insights into complex interactions between different brain’s reward systems regulating states.

Language: Английский

Citations

0
Can kisspeptin be a new treatment for sexual dysfunction? DOI

Julie Bakker

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans DOI
Edouard Mills, Mauro S.B. Silva, Virginia Delli

et al.

EBioMedicine, Journal Year: 2025, Volume and Issue: 115, P. 105689 - 105689

Published: April 11, 2025

Language: Английский

Citations

0
Brain circuits that regulate social behavior DOI Creative Commons
Hao Li, Zhe Zhao,

Shaofei Jiang

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Social interactions are essential for the survival of individuals and reproduction populations. stressors, such as social defeat isolation, can lead to emotional disorders cognitive impairments. Furthermore, dysfunctional behaviors hallmark symptoms various neuropsychiatric disorders, including autism spectrum disorder (ASD) post-traumatic stress (PTSD). Consequently, understanding neural circuit mechanisms underlying has become a major focus in neuroscience. behaviors, which encompass wide range expressions phases, regulated by complex networks. In this review, we summarize recent progress identifying circuits involved different types general investigation, preference, mating, aggression, parenting, prosocial dominance behaviors. We also outline associated with deficits ASD, schizophrenia, PTSD. Given pivotal role rodents behavior research, our review primarily focuses on these animals. Finally, propose future research directions, development specific behavioral paradigms, identification motor output, integration activity, transcriptome, connectome data, multifunctional roles neurons multiple targets, among brain regions.

Language: Английский

Citations

0
Gonadotropin-releasing hormone DOI
Miguel Ruiz-Cruz, Juan Roa, Manuel Tena‐Sempere

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

2
Kallmann syndrome: Diagnostics and management DOI

Rajiv Kumar Yadav,

Baiyu Qi,

Jianping Wen

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 565, P. 119994 - 119994

Published: Oct. 9, 2024

Language: Английский

Citations

1
Investigation of a Novel Mouse Model of Prader-Willi Syndrome with Invalidation of Necdin and Magel2 DOI Open Access

Pierre-Yves Barelle,

Alicia Sicardi,

Fabienne Schaller

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

Prader-Willi syndrome (PWS) is a multigenic disorder caused by the loss of seven contiguous paternally expressed genes. Mouse models with inactivation all PWS genes are lethal. Knockout (KO) mouse for each candidate gene were generated, but they lack functional interactions between Here, we revealed an interplay Necdin and Magel2 generated novel model (named Madin) deletion including both A subset Madin KO mice showed neonatal lethality. Behaviorally, surviving mutant exhibited sensory delays during infancy alterations in social exploration at adulthood. had lower body weight before weaning, persisting after weaning males only, reduced fat mass improved glucose tolerance. Delayed sexual maturation altered timing puberty onset observed mice. Adult displayed increased ventilation persistent increase apneas following hypercapnic challenge. Transcriptomics analyses dysregulation key circadian associated axonal function that also found hypothalamus patients PWS. At neuroanatomical levels, report impaired oxytocin neurons disrupted development melanocortin circuits. Together, these data indicate reliable more genetically relevant study

Language: Английский

Citations

0